Complementarity-determining region: Difference between revisions

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A single chain antibody fragment showing the positions of the three complementarity determining regions, CDR1, CDR2 and CDR3

Complementarity determining regions (CDR), are antibody or T cell receptor regions where the molecule complements an antigen's conformation. Thus, CDRs determine the molecule's specificity and make contact with a specific antigen. CDR1 and CDR2 are found in the variable (V) domain, and CDR3 includes some of V, all of diverse (D) (heavy chains only) and joint (J), and some of the constant (C) domains. CDR3 is the most variable.

A hypervariable domain, known for its unusually high level of sequence variation, exists as a flexible loop in CDR1. The hypervariable loops from each domain are brought together to create the antigen-binding site and thus determines the molecule's specificity.

References

External links

Complementarity+determining+regions at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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 [[Image:ScFv-rotation.gif|right|300px|thumb|A single chain antibody fragment showing the positions of the three complementarity determining regions, CDR1, CDR2 and CDR3]]
-'''Complementarity determining regions''' (CDR), are [[antibody]] or [[T cell receptor]] ''regions'' where the molecule ''complements'' an antigen's conformation. Thus, CDRs determine the molecule's specificity and make contact with a specific antigen. CDR1 and CDR2 are found in the variable (V) domain, and CDR3 includes some of V, all of diverse (D) (heavy chains only) and joint (J), and some of the constant (C) domains.
+'''Complementarity determining regions''' (CDR), are [[antibody]] or [[T cell receptor]] ''regions'' where the molecule ''complements'' an antigen's conformation. Thus, CDRs determine the molecule's specificity and make contact with a specific antigen. CDR1 and CDR2 are found in the variable (V) domain, and CDR3 includes some of V, all of diverse (D) (heavy chains only) and joint (J), and some of the constant (C) domains. CDR3 is the most variable.
+A ''hypervariable domain,'' known for its unusually high level of sequence variation, exists as a flexible loop in CDR1. The hypervariable loops from each domain are brought together to create the antigen-binding site and thus determines the molecule's specificity.
-A ''hypervariable domain,'' known for its unusually high level of sequence variation, exists as a flexible loop in CDR1.
 ==References==