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==Science==
==Science==
Grinnell's early scientific work contributed to discovery of the biological adhesion protein [[fibronectin]]<ref>Grinnell, F. (1978) Cellular adhesiveness and extracellular substrata. Int. Rev. Cytol. 53: 65-144.</ref> and helped to establish the importance of fibronectin in [[Biomedical Engineering|biomedical engineering]]<ref>Grinnell, F. (1982) The role of fibronectin in the bioreactivity of material surfaces. In: Biocompatible Polymers, Metals and Composites, ed., M. Szycher. American Society of Polymer Chemists pp. 673-679.</ref> and [[wound repair]].<ref>Grinnell, F. (1984) Fibronectin and wound healing. J. Cell Biochem. 26:107-116.</ref> Subsequently, his laboratory used fluid (exudate) from open wounds to analyze the human wound environment and discovered that [[Chronic_wound|chronic wounds]] contain high levels of proteolytic enzymes that degrade fibronectin.<ref>Grinnell, F., Ho, C-H., and Wysocki, A. (1992) Degradation of fibronectin and vitronectin in wound fluid: Analysis by cell blotting, immunoblotting, and cell adhesion assays. J. Invest. Dermatol. 98: 410-416.</ref><ref>Wysocki, A.B., Staiano-Coico, L., and Grinnell, F. (1993) Wound fluid from chronic ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J. Invest. Dermatol. 101: 64-68.</ref> Most recently, his research has focused on the use of three dimensional [[collagen]] matrices containing [[fibroblasts]] to learn about the tissue mechanics of [[fibrous connective tissue]].<ref>Grinnell, F. and Petroll, M. (2010) Cell motility and mechanics in three dimensional collagen matrices. Annu. Rev. Cell Devel. Biol. 26: 335–61.</ref>
Grinnell's early scientific work contributed to discovery of the biological adhesion protein [[fibronectin]]<ref>Grinnell, F. (1978) Cellular adhesiveness and extracellular substrata. Int. Rev. Cytol. 53: 65-144.</ref> and helped to establish the importance of fibronectin in [[Biomedical Engineering|biomedical engineering]]<ref>Grinnell, F. (1982) The role of fibronectin in the bioreactivity of material surfaces. In: Biocompatible Polymers, Metals and Composites, ed., M. Szycher. American Society of Polymer Chemists pp. 673-679.</ref> and [[wound repair]].<ref>Grinnell, F. (1984) Fibronectin and wound healing. J. Cell Biochem. 26:107-116.</ref> Subsequently, his laboratory used fluid (exudate) from open wounds to analyze the human wound environment and discovered that [[Chronic_wound|chronic wounds]] contain high levels of proteolytic enzymes<ref>Wysocki, A.B., Staiano-Coico, L., and Grinnell, F. (1993) Wound fluid from chronic ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J. Invest. Dermatol. 101: 64-68.</ref> and can degrade fibronectin.<ref>Grinnell, F., Ho, C-H., and Wysocki, A. (1992) Degradation of fibronectin and vitronectin in wound fluid: Analysis by cell blotting, immunoblotting, and cell adhesion assays. J. Invest. Dermatol. 98: 410-416.</ref> Most recently, his research has focused on the use of three dimensional [[collagen]] matrices containing [[fibroblasts]] to learn about the tissue mechanics of [[fibrous connective tissue]].<ref>Grinnell, F. and Petroll, M. (2010) Cell motility and mechanics in three dimensional collagen matrices. Annu. Rev. Cell Devel. Biol. 26: 335–61.</ref>


==Philosophy==
==Philosophy==
In bioethics, Grinnell engages in cross-disciplinary work at the boundary between science and philosophy. His goal is to inform public policy and to advance science education and public understanding of science.<ref>http://www.utsouthwestern.edu/utsw/cda/dept493066/files/571602.html</ref> Grinnell's work in bioethics is centered in the [[sociology of knowledge]], an approach developed through his studies with the [[Phenomenology (philosophy)|phenomenologists]] Richard Zaner and Maurice Natanson. He has published two books: ''The Scientific Attitude'', now is in its second edition;<ref>http://www.garfield.library.upenn.edu/essays/v15p147y1992-93.pdf</ref><ref>http://www.springerlink.com/content/j020j8732715g3v8/fulltext.pdf</ref> and ''Everyday Practice of Science: Where Intuition and Passion Meet Objectivity and Logic'',<ref>http://scienceblogs.com/ethicsandscience/2009/03/book_review_everyday_practice.php</ref><ref>http://www.guardian.co.uk/science/2010/oct/14/everyday-practice-science-frederick-grinnell</ref> which was a finalist in the [[Royal Society Prizes for Science Books#2010_Winner|2010 Royal Society Book Prize]] competition.<ref>http://royalsociety.org/science-books/the-books/</ref> Reviewers have recognized Chapter 6 of ''Everyday Practice'' for its calm approach to understanding the [[Science and religion|relationship between science and religion]].<ref>http://www.huffingtonpost.com/dan-agin/practicing-science--with_b_331746.html</ref><ref>http://blogs.discovermagazine.com/intersection/2010/10/04/everyday-practice-of-science/</ref>
In bioethics, Grinnell engages in cross-disciplinary work at the boundary between science and philosophy. His goal is to inform public policy and to advance science education and public understanding of science.<ref>http://www.utsouthwestern.edu/utsw/cda/dept493066/files/571602.html</ref> Grinnell's work in bioethics is centered in the [[sociology of knowledge]], an approach developed through his studies with the [[Phenomenology (philosophy)|phenomenologists]] Richard Zaner and Maurice Natanson. He has published two books: ''The Scientific Attitude'', now is in its second edition;<ref>http://www.garfield.library.upenn.edu/essays/v15p147y1992-93.pdf</ref><ref>http://www.springerlink.com/content/j020j8732715g3v8/fulltext.pdf</ref> and ''Everyday Practice of Science: Where Intuition and Passion Meet Objectivity and Logic'',<ref>http://scienceblogs.com/ethicsandscience/2009/03/book_review_everyday_practice.php</ref><ref>http://www.guardian.co.uk/science/2010/oct/14/everyday-practice-science-frederick-grinnell</ref> which was a finalist in the [[Royal Society Prizes for Science Books#2010_Winner|2010 Royal Society Book Prize]] competition.<ref>http://royalsociety.org/science-books/the-books/</ref> Reviewers have recognized Chapter 6 of ''Everyday Practice'' for its calm approach to describing the [[Science and religion|relationship between science and religion]].<ref>http://www.huffingtonpost.com/dan-agin/practicing-science--with_b_331746.html</ref><ref>http://blogs.discovermagazine.com/intersection/2010/10/04/everyday-practice-of-science/</ref>


==References==
==References==

Revision as of 22:43, 25 November 2010

Frederick Grinnell
File:Frederick Grinnell biologist.jpg
Born1945
NationalityAmerican
Scientific career
FieldsCell Biology and Bioethics
InstitutionsUT Southwestern Medical Center

Frederick Grinnell (born 1945 in Philadelphia, Pennsylvania) is an American professor of cell biology, also known for his work in bioethics.[1] Currently, he is professor of cell biology at University of Texas Southwestern Medical Center in Dallas, Texas. He took his undergraduate degree in chemistry at Clark University (1966) and Ph.D. in biochemistry at Tufts New England Medical Center (1970). He joined the faculty at UT Southwestern in 1972 and founded the UT Southwestern Ethics in Science and Medicine Program and Ethics Grand Rounds in 1998.[2]

Science

Grinnell's early scientific work contributed to discovery of the biological adhesion protein fibronectin[3] and helped to establish the importance of fibronectin in biomedical engineering[4] and wound repair.[5] Subsequently, his laboratory used fluid (exudate) from open wounds to analyze the human wound environment and discovered that chronic wounds contain high levels of proteolytic enzymes[6] and can degrade fibronectin.[7] Most recently, his research has focused on the use of three dimensional collagen matrices containing fibroblasts to learn about the tissue mechanics of fibrous connective tissue.[8]

Philosophy

In bioethics, Grinnell engages in cross-disciplinary work at the boundary between science and philosophy. His goal is to inform public policy and to advance science education and public understanding of science.[9] Grinnell's work in bioethics is centered in the sociology of knowledge, an approach developed through his studies with the phenomenologists Richard Zaner and Maurice Natanson. He has published two books: The Scientific Attitude, now is in its second edition;[10][11] and Everyday Practice of Science: Where Intuition and Passion Meet Objectivity and Logic,[12][13] which was a finalist in the 2010 Royal Society Book Prize competition.[14] Reviewers have recognized Chapter 6 of Everyday Practice for its calm approach to describing the relationship between science and religion.[15][16]

References

  1. ^ http://www.scienceprogress.org/2009/08/lab-bench-ethics/
  2. ^ http://www4.utsouthwestern.edu/FrederickGrinnell/dallasmorningnews2000.pdf
  3. ^ Grinnell, F. (1978) Cellular adhesiveness and extracellular substrata. Int. Rev. Cytol. 53: 65-144.
  4. ^ Grinnell, F. (1982) The role of fibronectin in the bioreactivity of material surfaces. In: Biocompatible Polymers, Metals and Composites, ed., M. Szycher. American Society of Polymer Chemists pp. 673-679.
  5. ^ Grinnell, F. (1984) Fibronectin and wound healing. J. Cell Biochem. 26:107-116.
  6. ^ Wysocki, A.B., Staiano-Coico, L., and Grinnell, F. (1993) Wound fluid from chronic ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J. Invest. Dermatol. 101: 64-68.
  7. ^ Grinnell, F., Ho, C-H., and Wysocki, A. (1992) Degradation of fibronectin and vitronectin in wound fluid: Analysis by cell blotting, immunoblotting, and cell adhesion assays. J. Invest. Dermatol. 98: 410-416.
  8. ^ Grinnell, F. and Petroll, M. (2010) Cell motility and mechanics in three dimensional collagen matrices. Annu. Rev. Cell Devel. Biol. 26: 335–61.
  9. ^ http://www.utsouthwestern.edu/utsw/cda/dept493066/files/571602.html
  10. ^ http://www.garfield.library.upenn.edu/essays/v15p147y1992-93.pdf
  11. ^ http://www.springerlink.com/content/j020j8732715g3v8/fulltext.pdf
  12. ^ http://scienceblogs.com/ethicsandscience/2009/03/book_review_everyday_practice.php
  13. ^ http://www.guardian.co.uk/science/2010/oct/14/everyday-practice-science-frederick-grinnell
  14. ^ http://royalsociety.org/science-books/the-books/
  15. ^ http://www.huffingtonpost.com/dan-agin/practicing-science--with_b_331746.html
  16. ^ http://blogs.discovermagazine.com/intersection/2010/10/04/everyday-practice-of-science/

External links

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