Mitocheck: Difference between revisions
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It was funded within the [[FP6|Sixth Framework programme]] of the [[European Commission]] for 5 years from 1 April 2004 and co-ordinated by [[Jan-Michael Peters|Dr Jan-Michael Peters]] from the [[Research Institute of Molecular Pathology]] (IMP) in [[Vienna]]. The full list of participants includes groups from [[Austria]], [[Germany]], [[Italy]], [[France]] and the [[United Kingdom]]. |
It was funded within the [[FP6|Sixth Framework programme]] of the [[European Commission]] for 5 years from 1 April 2004 and co-ordinated by [[Jan-Michael Peters|Dr Jan-Michael Peters]] from the [[Research Institute of Molecular Pathology]] (IMP) in [[Vienna]]. The full list of participants includes groups from [[Austria]], [[Germany]], [[Italy]], [[France]] and the [[United Kingdom]]. |
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The project tested all human [[gene]]s for involvement in mitosis by [[RNAi]]<ref>Neumann, B., Walter, T., Hériché, J., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., Wünsche, A., Satagopam, V., Schmitz, M., Chapuis, C., Gerlich, D., Schneider, R., Eils, R., Huber, W., Peters, J., Hyman, A., Durbin, R., Pepperkok, R., & Ellenberg, J. (2010) |
The project tested all human [[gene]]s for involvement in mitosis by [[RNAi]]<ref>Neumann, B., Walter, T., Hériché, J., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., Wünsche, A., Satagopam, V., Schmitz, M., Chapuis, C., Gerlich, D., Schneider, R., Eils, R., Huber, W., Peters, J., Hyman, A., Durbin, R., Pepperkok, R., & Ellenberg, J. (2010) "Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes" Nature, 464 (7289), 721-727 DOI: 10.1038/nature08869. [http://www.pubmed.org/20360735 Abstract]</ref>, then characterized subcellular localization and involvement in [[protein complex]]es of the proteins encoded by many of the identified mitotic genes<ref>Hutchins, J., Toyoda, Y., Hegemann, B., Poser, I., Hériché, J., Sykora, M., Augsburg, M., Hudecz, O., Buschhorn, B., Bulkescher, J., Conrad, C., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, M., Schloissnig, S., Steinmacher, I., Leuschner, M., Ssykor, A., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F., Mechtler, K., Hyman, A., & Peters, J. (2010) "Systematic Localization and Purification of Human Protein Complexes Identifies Chromosome Segregation Proteins" Science, 328 (5978), 593-599. DOI: 10.1126/science.1181348. [http://www.pubmed.org/20360068 Abstract]</ref>. Other aspects of the project have looked at mitotic protein [[phosphorylation]] and [[Translational medicine|translational]] opportunities for human [[health]]. |
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Mitocheck has made all of its data publicly available on its web site. |
Mitocheck has made all of its data publicly available on its web site. |
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2010 Apr 30;328(5978):593-9. |
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== References == |
== References == |
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<references/> |
<references/> |
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Revision as of 15:41, 3 August 2011
MitoCheck was an integrated research project which brought together leading European research groups to study systematically the regulation of mitosis in human cells.
It was funded within the Sixth Framework programme of the European Commission for 5 years from 1 April 2004 and co-ordinated by Dr Jan-Michael Peters from the Research Institute of Molecular Pathology (IMP) in Vienna. The full list of participants includes groups from Austria, Germany, Italy, France and the United Kingdom.
The project tested all human genes for involvement in mitosis by RNAi[1], then characterized subcellular localization and involvement in protein complexes of the proteins encoded by many of the identified mitotic genes[2]. Other aspects of the project have looked at mitotic protein phosphorylation and translational opportunities for human health. Mitocheck has made all of its data publicly available on its web site. 2010 Apr 30;328(5978):593-9.
References
- ^ Neumann, B., Walter, T., Hériché, J., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., Wünsche, A., Satagopam, V., Schmitz, M., Chapuis, C., Gerlich, D., Schneider, R., Eils, R., Huber, W., Peters, J., Hyman, A., Durbin, R., Pepperkok, R., & Ellenberg, J. (2010) "Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes" Nature, 464 (7289), 721-727 DOI: 10.1038/nature08869. Abstract
- ^ Hutchins, J., Toyoda, Y., Hegemann, B., Poser, I., Hériché, J., Sykora, M., Augsburg, M., Hudecz, O., Buschhorn, B., Bulkescher, J., Conrad, C., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, M., Schloissnig, S., Steinmacher, I., Leuschner, M., Ssykor, A., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F., Mechtler, K., Hyman, A., & Peters, J. (2010) "Systematic Localization and Purification of Human Protein Complexes Identifies Chromosome Segregation Proteins" Science, 328 (5978), 593-599. DOI: 10.1126/science.1181348. Abstract