Integrated stress response: Difference between revisions
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'''Integrated Stress Response''' (ISR)<ref name=surgicalnotes>{{cite web|title = surgicalnotes - Online Information Resource | url = http://www.surgicalnotes.co.uk/node/583}}</ref> is a [[Cellular Stress Response|cellular stress response]] common to all [[Eukaryote|eukaryotes]]. ISR |
'''Integrated Stress Response''' (ISR)<ref name=surgicalnotes>{{cite web|title = surgicalnotes - Online Information Resource | url = http://www.surgicalnotes.co.uk/node/583}}</ref> is a [[Cellular Stress Response|cellular stress response]] common to all [[Eukaryote|eukaryotes]]. ISR is a common denominator of different types of cellular stresses resulting in activation of at least one of the [[eIF-2 alpha (EIF2S1 ]]. |
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ISR results in the: |
ISR results in the: |
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*Down regulation of protein synthesis |
*Down regulation of the general protein synthesis (CAP-dependent) |
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*Up regulation of translation and expression of certain transcription factors, e.g. Activating Transcription Factor 4 ([[ATF4]]) |
*Up regulation of translation and expression of certain transcription factors, e.g. Activating Transcription Factor 4 ([[ATF4]]) |
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Revision as of 01:17, 20 August 2013
Integrated Stress Response (ISR)[1] is a cellular stress response common to all eukaryotes. ISR is a common denominator of different types of cellular stresses resulting in activation of at least one of the eIF-2 alpha (EIF2S1 .
ISR results in the:
- Down regulation of the general protein synthesis (CAP-dependent)
- Up regulation of translation and expression of certain transcription factors, e.g. Activating Transcription Factor 4 (ATF4)
References
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