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| pmc =
| pmc =
| pmid = 7699721
| pmid = 7699721
}}</ref> predicted<ref name="LeNovere1999a">
}}</ref> predicted<ref name="LeNovere1999a">{{Cite pmid|10233052}}</ref> and modeled their structure.<ref name="LeNovere2002">{{Cite pmid|11867716}}</ref> He also investigated the role of the alpha6 subunit in the dopaminergic neurons of the mesencephalon.<ref name="LeNovere1996">{{Cite pmid|8950106}}</ref><ref name="LeNovere1999b">{{Cite pmid|10574359}}</ref>
{{cite journal
| author = Le Novère N, Corringer PJ, Changeux JP
| date = 1999
| title = Improved secondary structure predictions for a nicotinic receptor subunit. Incorporation of solvent accessibility and experimental data into a 2D representation
| url =
| journal = Biophysical Journal
| publisher =
| volume = 76
| issue =
| pages = 2329-2345
| doi = 10.1016/S0006-3495(99)77390-X
| pmc = PMC1300207
| pmid = 10233052
}}</ref> and modeled their structure.<ref name="LeNovere2002">
{{cite journal
| author = Le Novère N, Grutter T, Changeux JP
| date = 2002
| title = Models of the extracellular domain of the nicotinic receptors and of agonist and Ca++ binding sites
| url =
| journal = Proceedings of the National Academy of Sciences USA
| publisher =
| volume =
| issue =
| pages =
| doi = 10.1073/pnas.042699699
| pmc = PMC122498
| pmid = 11867716
}}
</ref> He also investigated the role of the alpha6 subunit in the dopaminergic neurons of the mesencephalon.<ref name="LeNovere1996">
{{cite journal
| author = Le Novère N, Zoli M, Changeux JP
| date = 1996
| title = Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain
| url =
| journal = European Journal of Neuroscience
| publisher =
| volume = 8
| issue =
| pages = 2428-2439
| doi = 10.1111/j.1460-9568.1996.tb01206.x
| pmc =
| pmid = 8950106
}}
</ref><ref name="LeNovere1999b">
{{cite journal
| author = Le Novère N, Zoli M, Léna C, Ferrari R, Picciotto MR, Merlo-Pich E, Changeux JP
| date = 1999
| title = Involvement of α6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion
| url =
| journal = NeuroReport
| publisher =
| volume = 10
| issue = 12
| pages = 2497-2501
| doi =
| pmc =
| pmid = 10574359
}}</ref>


During his post-doctoral fellowship in the group of [[Dennis Bray]] at the [[University of Cambridge]], he modeled the molecular networks underlying bacterial [[chemotaxis]].<ref name="Shimizu2000">{{Cite pmid|11056533}}</ref><ref name="Duke2001">{{Cite pmid|11327786}}</ref> Le Novère then became involved in the development standards to share [[mathematical models]] such as [[SBML]],<ref name="Hucka2003">{{Cite pmid|12611808}}</ref> of which he would later become editor.
During his post-doctoral fellowship in the group of [[Dennis Bray]] at the [[University of Cambridge]], he modeled the molecular networks underlying bacterial [[chemotaxis]].<ref name="Shimizu2000">
{{cite journal
| author = Shimizu TS, Le Novère N, Levin MD, Beavil AJ, Sutton BJ, Bray D
| date = 2000
| title = Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis
| url =
| journal = Nature Cell Biology
| publisher =
| volume = 2
| issue =
| pages = 792-796
| doi = 10.1038/35041030
| pmc =
| pmid = 11056533
}}
</ref><ref name="Duke2001">
{{Cite pmid|11327786}}</ref> Le Novère then became involved in the development standards to share [[mathematical models]] such as [[SBML]],<ref name="Hucka2003">{{Cite pmid|12611808}}</ref> of which he would later become editor.


In 2003, Le Novère built a research group at the [[European Bioinformatics Institute|European Bioinformatics Institute (EMBL-EBI)]]. The group studied the [[signaling pathways]] underlying [[synaptic plasticity]], in particular the allosteric calcium sensors.<ref name="Stefan2008">{{Cite pmid|18669651}}</ref><ref name="Li2012">{{Cite pmid|22962589}}</ref><ref name="Lai2015">{{Cite pmid|25611683}}</ref>
In 2003, Le Novère built a research group at the [[European Bioinformatics Institute|European Bioinformatics Institute (EMBL-EBI)]]. The group studied the [[signaling pathways]] underlying [[synaptic plasticity]], in particular the allosteric calcium sensors.<ref name="Stefan2008">{{cite journal
| author = Stefan MI, Edelstein SJ, Le Novère N
In parallel, his group coordinated the development of a consistent set of standards in systems biology, including the graphical notation [[SBGN]],<ref name="LeNovere2009">{{Cite pmid|19668183}}</ref> the guidelines [[MIRIAM]]<ref name="LeNovere2005">{{Cite pmid|16333295}}</ref> and [[MIASE]],<ref name="Waltemath2011a">{{Cite pmid|22027554}}</ref> the languages [[SED-ML]]<ref name="Waltemath2011b">{{Cite pmid|22172142}}</ref> and PharmML, and ontologies<ref name="Waltemath2011a">{{Cite pmid|22027554}}</ref> such as the [[Systems Biology Ontology]]. He also created [[BioModels Database]]<ref name="LeNovere2006">{{Cite pmid|16381960}}</ref> and the [[Identifiers.org]]<ref name="Juty2012">{{Cite pmid|22140103}}</ref> URIs.
| date = 2008
| title = An allosteric model of calmodulin explains differential activation of PP2B and CaMKII
| url =
| journal =
| publisher =
| volume = 105
| issue =
| pages = 10768-10773
| doi = 10.1073/pnas.0804672105
| pmc = PMC2504824
| pmid = 18669651
}}</ref><ref name="Li2012">{{cite journal
| author = Li L, Stefan MI, Le Novère N
| date = 2012
| title = Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII
| url =
| journal = PLoS ONE
| publisher =
| volume = 7
| issue = 9
| pages = e43810
| doi = 10.1371/journal.pone.0043810
| pmc = PMC3433481
| pmid = 22962589
}}</ref><ref name="Lai2015">{{cite journal
| author = Lai M, Brun D, Edelstein SJ, Le Novère N
| date = 2015
| title = Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions
| url =
| journal = PLoS Computational Biology
| publisher =
| volume = 10
| issue = 1
| pages = e0116616
| doi = 10.1371/journal.pcbi.1004063
| pmc = PMC4303274
| pmid = 25611683
}}</ref>
In parallel, his group coordinated the development of a consistent set of standards in systems biology, including the graphical notation [[SBGN]],<ref name="LeNovere2009">{{cite journal
| author = Le Novère N, Hucka M, Mi H, Moodie S, Shreiber F, Sorokin A, Demir E, Wegner K, Aladjem M, Wimalaratne S, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman T, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H
| date = 2009
| title = The Systems Biology Graphical Notation
| url =
| journal = Nature Biotechnology
| publisher =
| volume = 27
| issue =
| pages = 735-741
| doi = 10.1038/nbt.1558
| pmc =
| pmid = 19668183
}}
</ref> the guidelines [[MIRIAM]]<ref name="LeNovere2005">{{cite journal
| author = Le Novère N, Finney A, Hucka M, Bhalla US, Campagne F, Collado-Vides J, Crampin EJ, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL
| date = 2005
| title = Minimum Information Requested In the Annotation of biochemical Models (MIRIAM)
| url =
| journal = Nature Biotechnology
| publisher =
| volume = 23
| issue =
| pages = 1509-1515
| doi = 10.1038/nbt1156
| pmc =
| pmid = 16333295
}}</ref> and [[MIASE]],<ref name="Waltemath2011a">{{cite journal
| author = Waltemath D, Adams R, Beard DA, Bergmann FT, Bhalla US, Britten R, Chelliah V, Cooling MT, Cooper J, Crampin E, Garny A, Hoops S, Hucka M, Hunter P, Klipp E, Laibe C, Miller A, Moraru I, Nickerson D, Nielsen P, Nikolski M, Sahle S, Sauro HM, Schmidt H, Snoep JL, Tolle D, Wolkenhauer O, Le Novère N
| date = 2011
| title = Minimum Information About a Simulation Experiment (MIASE
| url =
| journal = PLoS Computational Biology
| publisher =
| volume = 7
| issue = 4
| pages = e1001122
| doi = 10.1371/journal.pcbi.1001122
| pmc = PMC3084216
| pmid = 21552546
}}</ref> the languages [[SED-ML]]<ref name="Waltemath2011b">{{cite journal
| author = Waltemath D, Adams R, Bergmann FT, Hucka M, Kolpakov F, Miller AK, Moraru II, Nickerson D, Sahle S, Snoep JL, Le Novère N
| date = 2011
| title = Reproducible computational biology experiments with SED-ML - The Simulation Experiment Description Markup Language
| url =
| journal = BMC Systems Biology
| publisher =
| volume = 5
| issue =
| pages = 198
| doi = 10.1186/1752-0509-5-198
| pmc = PMC3292844
| pmid = 22172142
}}</ref> and PharmML, and ontologies<ref name="Courtot2011">{{cite journal
| author = Courtot M, Juty N, Knüpfer C, Waltemath D, Zhukova A, Dräger A, Dumontier M, Finney A, Golebiewski M, Hastings J, Hoops S, Keating S, Kell DB, Kerrien S, Lawson J, Lister A, Lu J, Machne R, Mendes P, Pocock M, Rodriguez N, Villeger A, Wilkinson DJ, Wimalaratne S, Laibe C, Hucka M, Le Novère N
| date = 2011
| title = Controlled vocabularies and semantics in Systems Biology
| url =
| journal = Molecular Systems Biology
| publisher =
| volume = 7
| issue =
| pages = 543
| doi = 10.1038/msb.2011.77
| pmc = PMC3159965
| pmid = 22027554
}}</ref> such as the [[Systems Biology Ontology]]. He also created [[BioModels Database]]<ref name="LeNovere2006">{{cite journal
| author = Le Novère N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M
| date = 2006
| title = BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems
| url =
| journal = Nucleic Acids Research
| publisher =
| volume = 34
| issue =
| pages = D689-D691
| doi = 10.1093/nar/gkj092
| pmc = PMC1347454
| pmid = 16381960
}}</ref> and the [[Identifiers.org]]<ref name="Juty2012">{{cite journal
| author = Juty N, Le Novère N, Laibe C
| date = 2012
| title = Identifiers.org and MIRIAM Registry: community resources to provide persistent identification
| url =
| journal = Nucleic Acids Research
| publisher =
| volume = 40
| issue =
| pages = D580-D586
| doi = 10.1093/nar/gkr1097
| pmc = PMC3245029
| pmid = 22140103
}}
</ref> URIs.


Le Novère moved his group to the [[Babraham Institute]] in 2012.
Le Novère moved his group to the [[Babraham Institute]] in 2012.

Revision as of 21:02, 26 July 2015

Nicolas Le Novère
Born(1969-03-12)12 March 1969
Alma mater
Known forBioModels Database
Scientific career
Fields
Institutions
Academic advisors

Nicolas Le Novère is a British and French biologist, senior group leader at the Babraham Institute. His research is focused on modeling signaling pathways and developing tools to share mathematical models.

Education

Le Novère obtained his Baccalauréat at the Prytanée National Militaire. He received a MSc (1993) in Biology and Biochemistry from the École Normale Supérieure, a BSc in Cellular Biology and Physiology (1991), and a PhD in Molecular and Cellular Pharmacology (1998) from the Pierre and Marie Curie University.[1] From 1999 to 2001, he was a Postdoctoral Fellow in the laboratory of Dennis Bray at the University of Cambridge (UK).

Research

The first part of Le Novère's career, in the laboratory of Jean-Pierre Changeux at the Pasteur Institute, was focused on studying Nicotinic acetylcholine receptors in the brain. He reconstructed their phylogeny,[2] predicted[3] and modeled their structure.[4] He also investigated the role of the alpha6 subunit in the dopaminergic neurons of the mesencephalon.[5][6]

During his post-doctoral fellowship in the group of Dennis Bray at the University of Cambridge, he modeled the molecular networks underlying bacterial chemotaxis.[7][8] Le Novère then became involved in the development standards to share mathematical models such as SBML,[9] of which he would later become editor.

In 2003, Le Novère built a research group at the European Bioinformatics Institute (EMBL-EBI). The group studied the signaling pathways underlying synaptic plasticity, in particular the allosteric calcium sensors.[10][11][12] In parallel, his group coordinated the development of a consistent set of standards in systems biology, including the graphical notation SBGN,[13] the guidelines MIRIAM[14] and MIASE,[15] the languages SED-ML[16] and PharmML, and ontologies[17] such as the Systems Biology Ontology. He also created BioModels Database[18] and the Identifiers.org[19] URIs.

Le Novère moved his group to the Babraham Institute in 2012.

He is currently associate editor of the journals BMC Systems Biology and NPJ Systems Biology and Applications.

References

  1. ^ "Nicolas Le Novere CV". Retrieved 25 July 2015.
  2. ^ Le Novère N, Changeux JP (1995). "Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells". Journal of Molecular Evolution. 40: 155–172. doi:10.1007/BF00167110. PMID 7699721.
  3. ^ Le Novère N, Corringer PJ, Changeux JP (1999). "Improved secondary structure predictions for a nicotinic receptor subunit. Incorporation of solvent accessibility and experimental data into a 2D representation". Biophysical Journal. 76: 2329–2345. doi:10.1016/S0006-3495(99)77390-X. PMC 1300207. PMID 10233052.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link)
  4. ^ Le Novère N, Grutter T, Changeux JP (2002). "Models of the extracellular domain of the nicotinic receptors and of agonist and Ca++ binding sites". Proceedings of the National Academy of Sciences USA. doi:10.1073/pnas.042699699. PMC 122498. PMID 11867716.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link)
  5. ^ Le Novère N, Zoli M, Changeux JP (1996). "Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain". European Journal of Neuroscience. 8: 2428–2439. doi:10.1111/j.1460-9568.1996.tb01206.x. PMID 8950106.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Le Novère N, Zoli M, Léna C, Ferrari R, Picciotto MR, Merlo-Pich E, Changeux JP (1999). "Involvement of α6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion". NeuroReport. 10 (12): 2497–2501. PMID 10574359.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Shimizu TS, Le Novère N, Levin MD, Beavil AJ, Sutton BJ, Bray D (2000). "Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis". Nature Cell Biology. 2: 792–796. doi:10.1038/35041030. PMID 11056533.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11327786, please use {{cite journal}} with |pmid=11327786 instead.
  9. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12611808, please use {{cite journal}} with |pmid=12611808 instead.
  10. ^ Stefan MI, Edelstein SJ, Le Novère N (2008). "An allosteric model of calmodulin explains differential activation of PP2B and CaMKII". 105: 10768–10773. doi:10.1073/pnas.0804672105. PMC 2504824. PMID 18669651. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link)
  11. ^ Li L, Stefan MI, Le Novère N (2012). "Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII". PLoS ONE. 7 (9): e43810. doi:10.1371/journal.pone.0043810. PMC 3433481. PMID 22962589.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  12. ^ Lai M, Brun D, Edelstein SJ, Le Novère N (2015). "Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions". PLoS Computational Biology. 10 (1): e0116616. doi:10.1371/journal.pcbi.1004063. PMC 4303274. PMID 25611683.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  13. ^ Le Novère N, Hucka M, Mi H, Moodie S, Shreiber F, Sorokin A, Demir E, Wegner K, Aladjem M, Wimalaratne S, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman T, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H (2009). "The Systems Biology Graphical Notation". Nature Biotechnology. 27: 735–741. doi:10.1038/nbt.1558. PMID 19668183.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ Le Novère N, Finney A, Hucka M, Bhalla US, Campagne F, Collado-Vides J, Crampin EJ, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL (2005). "Minimum Information Requested In the Annotation of biochemical Models (MIRIAM)". Nature Biotechnology. 23: 1509–1515. doi:10.1038/nbt1156. PMID 16333295.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  15. ^ Waltemath D, Adams R, Beard DA, Bergmann FT, Bhalla US, Britten R, Chelliah V, Cooling MT, Cooper J, Crampin E, Garny A, Hoops S, Hucka M, Hunter P, Klipp E, Laibe C, Miller A, Moraru I, Nickerson D, Nielsen P, Nikolski M, Sahle S, Sauro HM, Schmidt H, Snoep JL, Tolle D, Wolkenhauer O, Le Novère N (2011). "Minimum Information About a Simulation Experiment (MIASE". PLoS Computational Biology. 7 (4): e1001122. doi:10.1371/journal.pcbi.1001122. PMC 3084216. PMID 21552546.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  16. ^ Waltemath D, Adams R, Bergmann FT, Hucka M, Kolpakov F, Miller AK, Moraru II, Nickerson D, Sahle S, Snoep JL, Le Novère N (2011). "Reproducible computational biology experiments with SED-ML - The Simulation Experiment Description Markup Language". BMC Systems Biology. 5: 198. doi:10.1186/1752-0509-5-198. PMC 3292844. PMID 22172142.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  17. ^ Courtot M, Juty N, Knüpfer C, Waltemath D, Zhukova A, Dräger A, Dumontier M, Finney A, Golebiewski M, Hastings J, Hoops S, Keating S, Kell DB, Kerrien S, Lawson J, Lister A, Lu J, Machne R, Mendes P, Pocock M, Rodriguez N, Villeger A, Wilkinson DJ, Wimalaratne S, Laibe C, Hucka M, Le Novère N (2011). "Controlled vocabularies and semantics in Systems Biology". Molecular Systems Biology. 7: 543. doi:10.1038/msb.2011.77. PMC 3159965. PMID 22027554.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link)
  18. ^ Le Novère N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M (2006). "BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems". Nucleic Acids Research. 34: D689–D691. doi:10.1093/nar/gkj092. PMC 1347454. PMID 16381960.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link)
  19. ^ Juty N, Le Novère N, Laibe C (2012). "Identifiers.org and MIRIAM Registry: community resources to provide persistent identification". Nucleic Acids Research. 40: D580–D586. doi:10.1093/nar/gkr1097. PMC 3245029. PMID 22140103.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link)

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