Talk:Systemic scleroderma: Difference between revisions

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Heat is bad as is the cold for scleroderma. Heat causes excessive fatigue more so then you allready get with this disease. The harding of the skin can be very life threatening. I am not getting any blood to my rear end I can't stand the pain. Sleeping is very hard to do. It is hard to stand, sit or lie down. Because of the hard skin there is no blood flow along my skin between my two cheeks, it is raw and getting open sores much like the ones on fingers of others with scleroderma. We must get the word out about this disease, I did not know about it till I was told that I have it.

I agree. My mother has the disease and it took doctors years to arrive at this diagnosis. she does not show very much of the characteristic skin hardening, but she makes up for it with the other symptoms. --Morbid-o 12:44, 3 Jun 2005 (UTC)

Wikipedia is flawed. Information about something as obscure as scleroderma needs to come from a source that is current and updated often. It's impossible to get that on a site that not only requires you to write the update but to document it. Go to the source for current, medically-reviewed information about scleroderma - www.scleroderma.org.

I agree that this article should be based on authoratitive sources, preferably a recent systematic review. Many medical articles are indeed updated frequently, but there is clearly nobody around who is willing to nurture this article. Instead of criticism, how about you put some work in to improve this article? JFW | T@lk 00:45, 17 November 2005 (UTC)[reply]

I have it all ready, just haven't had the time or stamina (I have the systemic disease) to learn how to do the Wikipedia "documentation." I cite the places I get info from in the article and don't know why I have to use some unique coding system.

Coding system? It's Wiki markup and very easy to learn, see how to edit a page for more. JFW | T@lk 15:00, 22 November 2005 (UTC)[reply]

I'm happy it's easy for you to learn. If you had the disease, you'd understand why "easy" is relative.

I'm unsure how scleroderma symptoms should impair Wikipedia editing more than any other form of typing. I did not intend to offend you. JFW | T@lk 14:04, 15 December 2005 (UTC)[reply]

I heard colchicine is an effective treatment for schleroderma, but don't want to add it without proof. If anyone wants to look this up...

This study laments the absence of well-designed trials of colchicine in scleroderma. There's a nice subject for your PhD! JFW | T@lk 23:38, 25 April 2006 (UTC)[reply]

Pathogenesis

I wrote the pathogenesis section completely on the basis of Jimenez & Derk's excellent review. One wishes there were more systemic reviews of this type. Further sources would still be welcome. The review was in 2004. Has anything else come to the surface that is worth discussing? JFW | T@lk 23:38, 25 April 2006 (UTC)[reply]

Nice additions. The review article is quite good. -- Samir धर्म 21:07, 1 May 2006 (UTC)[reply]

Thanks. Have you anything to add with respect to the oesophageal dysmotility and malabsorption? JFW | T@lk 16:49, 2 May 2006 (UTC)[reply]

Added a bit on complications. -- Samir धर्म 08:22, 14 May 2006 (UTC)[reply]

Scleroderma : help me

If Scleroderma is a genetic diseases? my mother has the diseases, what are the chances that i will have it?(i mean is it dominant diseases?) what pecautions should i take to avoid the diseaes?````

There does appear to be a genetic component to the disease as suggested by the following abstract:

Assassi S, Tan FK. Genetics of scleroderma: update on single nucleotide polymorphism analysis and microarrays. Curr Opin Rheumatol. 2005 Nov;17(6):761-7. Review. PMID 16224255.

I suggest you talk to your doctor. Nephron T|C 08:34, 28 October 2006 (UTC)[reply]

Deleted BoTox reference

This cannot be correct. Scleroderma reduces Lower Esophageal Sphincter(LES) pressure by reducing the ability of the muscles to contract, causing the GE junction to be slack, and allowing the regurgitation of stomach acid into the esophagus. This causes esophageal erosion, Barrett's Esophagus, and esophageal strictures. Strictures are not muscular, they are fibrous connective tissue bands caused by the corrosive scarring of the stomach acid. The treatment for strictures is by esophageal dilitation with a device called a Bouge (among others).

Botulinum Toxin, maybe the most potent toxin known to man, is a paralytic substance. There is no need to use a paralytic on an already slackened LES. Since esophageal strictures are fibrous bands and not muscular, they cannot be treated with a paralytic. In fact, BoTox is one of the treatments for Achalasia, which is the failure of the LES to relax; the exact OPPOSITE effect of Scleroderma.

I hope that it is Ok that I delete the Botulinum toxin reference from the GI effects section.

Cochise11 00:01, 2 April 2007 (UTC)[reply]

8-) No this is NOT an April fools joke.

Is there a reason why Botulinum Toxin is still on the page? It is not a viable treatment option for scleroderma.

Cochise11 01:49, 5 April 2007 (UTC)[reply]