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'''Erich Sackmann''' (born 26 November 1934) is a German experimental physicist and a pioneer of biophysics in Europe.<ref name=j1>{{Cite journal | doi = 10.1039/C3SM51910D| pmid = 24651316| title = Physics of cell adhesion: Some lessons from cell-mimetic systems| journal = Soft Matter| volume = 10| issue = 11| pages = 1644–59| year = 2014| last1 = Sackmann | first1 = E. | last2 = Smith | first2 = A. S. A. | bibcode = 2014SMat...10.1644S | pmc=4028615}}</ref>
'''Erich Sackmann''' (born 26 November 1934) is a German experimental physicist and a pioneer of biophysics in Europe.<ref name=j1>{{Cite journal | doi = 10.1039/C3SM51910D| pmid = 24651316| title = Physics of cell adhesion: Some lessons from cell-mimetic systems| journal = Soft Matter| volume = 10| issue = 11| pages = 1644–59| year = 2014| last1 = Sackmann | first1 = E. | last2 = Smith | first2 = A. S. A. | bibcode = 2014SMat...10.1644S | pmc=4028615}}</ref>

==Education==
Sackmann obtained his MSc (1961) and PhD (1964) degrees from the [[University of Stuttgart]] in the group of [[Theodor Förster]].


==Career==
==Career==
Sackmann obtained his MSc (1961) and PhD (1964) degrees from the [[University of Stuttgart]] in the group of [[Theodor Förster]]. He then spent two years at [[Bell Telephone Laboratories]] in Murray Hill, New Jersey, and six years at [[Max Planck Institute for Biophysical Chemistry]] in Göttingen, Germany. Between 1974 and 1980 he was professor of physics and head of the biophysics department at [[Universität Ulm]], and from 1980 until retirement in 2003 he held the same positions at the Physics Department of the [[Technical University of Munich]].<ref name=j1/>
Following his PhD, Sackmann then spent two years at [[Bell Telephone Laboratories]] in Murray Hill, New Jersey, and six years at [[Max Planck Institute for Biophysical Chemistry]] in Göttingen, Germany. Between 1974 and 1980 he was professor of physics and head of the biophysics department at [[Universität Ulm]], and from 1980 until retirement in 2003 he held the same positions at the Physics Department of the [[Technical University of Munich]].<ref name=j1/>


===Research===
Sackmann dedicated a lifetime of research towards probing the living cell with tools of physics, long before biophysics was the mode of the day. Considered as a father of biophysics in Europe, he pioneered, along with others, the idea of a “bottom up” approach towards understanding the cell – starting from relatively simple systems like lipid bilayers, giant vesicles and actin in solution and going towards more and more complex systems to reach eventually an understanding at the level of the entire cell.
Sackmann dedicated a lifetime of research towards probing the living cell with tools of physics, long before biophysics was the mode of the day. Considered as a father of biophysics in Europe, he pioneered, along with others, the idea of a "bottom up" approach towards understanding the cell – starting from relatively simple systems like lipid bilayers, giant vesicles and actin in solution and going towards more and more complex systems to reach eventually an understanding at the level of the entire cell.


More than 200 publications and several books [http://dispatch.opac.ddb.de/DB=4.1/REL?PPN=107150948 Literatur von und über Erich Sackmann] testify to his contributions to [[soft matter]] and [[biophysics]]. His early work was mainly on [[lyotropic]] [[liquid crystals]] and lipid [[Biological membrane|membranes]]. Later, along with his students he laid the foundations of our current understanding of membrane adhesion. Over the years, his team developed and improved the technique of [[reflection interference contrast microscopy]] – RICM (which is quantitative [[interference reflection microscopy]] – IRM) <ref>{{Cite journal | doi = 10.1051/jp2:1993163| title = Imaging optical thicknesses and separation distances of phospholipid vesicles at solid surfaces| journal = Journal de Physique II| volume = 3| issue = 5| pages = 727–748| year = 1993| last1 = Rädler | first1 = J. | last2 = Sackmann | first2 = E. | bibcode = 1993JPhy2...3..727R| url = http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-3788-0}}</ref><ref>{{Cite journal | doi = 10.1364/AO.37.006892| pmid = 18301506| title = Microinterferometry: Three-Dimensional Reconstruction of Surface Microtopography for Thin-Film and Wetting Studies by Reflection Interference Contrast Microscopy (RICM)| journal = Applied Optics| volume = 37| issue = 29| pages = 6892–905| year = 1998| last1 = Wiegand | first1 = G. | last2 = Neumaier | first2 = K. R. | last3 = Sackmann | first3 = E. | bibcode = 1998ApOpt..37.6892W}}</ref> – a powerful tool to probe adhesion of membranes and thin films. Collaborations with theoreticians like Reinhard Lipowsky, Udo Seifert and [[Robijn Bruinsma]] have led to seminal works on adhesion of cell mimetic giant vesicles<ref>{{Cite journal | doi = 10.1002/1439-7641(20020315)3:3<262::AID-CPHC262>3.0.CO;2-U| pmid = 12503172| title = Cell Adhesion as Wetting Transition?| journal = ChemPhysChem| volume = 3| issue = 3| pages = 262–9| year = 2002| last1 = Sackmann | first1 = E. | last2 = Bruinsma | first2 = R. F. }}</ref> (also called [[liposomes]]).
More than 200 publications and several books [http://dispatch.opac.ddb.de/DB=4.1/REL?PPN=107150948 Literatur von und über Erich Sackmann] testify to his contributions to [[soft matter]] and [[biophysics]]. His early work was mainly on [[lyotropic]] [[liquid crystals]] and lipid [[Biological membrane|membranes]]. Later, along with his students he laid the foundations of our current understanding of membrane adhesion. Over the years, his team developed and improved the technique of [[reflection interference contrast microscopy]] – RICM (which is quantitative [[interference reflection microscopy]] – IRM) <ref>{{Cite journal | doi = 10.1051/jp2:1993163| title = Imaging optical thicknesses and separation distances of phospholipid vesicles at solid surfaces| journal = Journal de Physique II| volume = 3| issue = 5| pages = 727–748| year = 1993| last1 = Rädler | first1 = J. | last2 = Sackmann | first2 = E. | bibcode = 1993JPhy2...3..727R| url = http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-3788-0}}</ref><ref>{{Cite journal | doi = 10.1364/AO.37.006892| pmid = 18301506| title = Microinterferometry: Three-Dimensional Reconstruction of Surface Microtopography for Thin-Film and Wetting Studies by Reflection Interference Contrast Microscopy (RICM)| journal = Applied Optics| volume = 37| issue = 29| pages = 6892–905| year = 1998| last1 = Wiegand | first1 = G. | last2 = Neumaier | first2 = K. R. | last3 = Sackmann | first3 = E. | bibcode = 1998ApOpt..37.6892W}}</ref> – a powerful tool to probe adhesion of membranes and thin films. Collaborations with theoreticians like Reinhard Lipowsky, Udo Seifert and [[Robijn Bruinsma]] have led to seminal works on adhesion of cell mimetic giant vesicles<ref>{{Cite journal | doi = 10.1002/1439-7641(20020315)3:3<262::AID-CPHC262>3.0.CO;2-U| pmid = 12503172| title = Cell Adhesion as Wetting Transition?| journal = ChemPhysChem| volume = 3| issue = 3| pages = 262–9| year = 2002| last1 = Sackmann | first1 = E. | last2 = Bruinsma | first2 = R. F. }}</ref> (also called [[liposomes]]).
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His research interests include: physics of [[self assembly]] and function of artificial and [[biological membranes]], [[viscoelastic]] [[microscopy]] of cells, physics of the [[actin]] based [[cytoskeleton]]: micro-[[rheology]] of macromolecular networks, applications of solid-supported lipid-protein membranes, ultrathin hydrated [[polymer]] layers and polymer/membrane composite films and [[neutron]] [[Reflectivity]] as a new tool to study the [[self assembly]] of membrane associated proteins.
His research interests include: physics of [[self assembly]] and function of artificial and [[biological membranes]], [[viscoelastic]] [[microscopy]] of cells, physics of the [[actin]] based [[cytoskeleton]]: micro-[[rheology]] of macromolecular networks, applications of solid-supported lipid-protein membranes, ultrathin hydrated [[polymer]] layers and polymer/membrane composite films and [[neutron]] [[Reflectivity]] as a new tool to study the [[self assembly]] of membrane associated proteins.


==Selected bibliography==
Along with Reinhard Lipowsky, he has authored "the Structure and Dynamics of Membranes". Recently, along with Rudolf Merkel, he has published "Lehrbuch der Biophysik" – a text book on biophysics aimed at students and researchers.
Along with Reinhard Lipowsky, he has authored "the Structure and Dynamics of Membranes". Recently, along with Rudolf Merkel, he has published "Lehrbuch der Biophysik" – a text book on biophysics aimed at students and researchers.


==Awards and honors==
He was elected a [[Fellow of the American Physical Society]] in 2002. <ref> {{cite web|url=https://www.aps.org/programs/honors/fellowships/archive-all.cfm?initial=&year=2002&unit_id=&institution=|title=APS Fellow Archive|publisher=APS|access-date=17 September 2020}} </ref> In recognition of his research work, in 2006, he was awarded the [[Stern-Gerlach-Medaille|Stern-Gerlach-Medal]] by the [[Deutsche Physikalische Gesellschaft|DPG, German Physical Society]].
He was elected a [[Fellow of the American Physical Society]] in 2002. <ref> {{cite web|url=https://www.aps.org/programs/honors/fellowships/archive-all.cfm?initial=&year=2002&unit_id=&institution=|title=APS Fellow Archive|publisher=APS|access-date=17 September 2020}} </ref> In recognition of his research work, in 2006, he was awarded the [[Stern-Gerlach-Medaille|Stern-Gerlach-Medal]] by the [[Deutsche Physikalische Gesellschaft|DPG, German Physical Society]].


==See also==
==See also==
*[[Lipid raft]]
* [[Lipid raft]]


==References==
==References==

Revision as of 19:44, 28 May 2024

Erich Sackmann
Born26 November 1934 (1934-11-26) (age 89)
Baiersbronn, Germany
Alma materUniversity of Stuttgart
Scientific career
FieldsBiophysics

Erich Sackmann (born 26 November 1934) is a German experimental physicist and a pioneer of biophysics in Europe.[1]

Education

Sackmann obtained his MSc (1961) and PhD (1964) degrees from the University of Stuttgart in the group of Theodor Förster.

Career

Following his PhD, Sackmann then spent two years at Bell Telephone Laboratories in Murray Hill, New Jersey, and six years at Max Planck Institute for Biophysical Chemistry in Göttingen, Germany. Between 1974 and 1980 he was professor of physics and head of the biophysics department at Universität Ulm, and from 1980 until retirement in 2003 he held the same positions at the Physics Department of the Technical University of Munich.[1]

Research

Sackmann dedicated a lifetime of research towards probing the living cell with tools of physics, long before biophysics was the mode of the day. Considered as a father of biophysics in Europe, he pioneered, along with others, the idea of a "bottom up" approach towards understanding the cell – starting from relatively simple systems like lipid bilayers, giant vesicles and actin in solution and going towards more and more complex systems to reach eventually an understanding at the level of the entire cell.

More than 200 publications and several books Literatur von und über Erich Sackmann testify to his contributions to soft matter and biophysics. His early work was mainly on lyotropic liquid crystals and lipid membranes. Later, along with his students he laid the foundations of our current understanding of membrane adhesion. Over the years, his team developed and improved the technique of reflection interference contrast microscopy – RICM (which is quantitative interference reflection microscopy – IRM) [2][3] – a powerful tool to probe adhesion of membranes and thin films. Collaborations with theoreticians like Reinhard Lipowsky, Udo Seifert and Robijn Bruinsma have led to seminal works on adhesion of cell mimetic giant vesicles[4] (also called liposomes).

Another of his interests is the cytoskeleton and its dynamics. To study cytoskeletal dynamics, his team developed magnetic tweezers capable of exerting very small pulling forces. He has contributed to our understanding of the dynamics of single actin filaments, actin networks as well as intact living cells.[5][6][7]

His research interests include: physics of self assembly and function of artificial and biological membranes, viscoelastic microscopy of cells, physics of the actin based cytoskeleton: micro-rheology of macromolecular networks, applications of solid-supported lipid-protein membranes, ultrathin hydrated polymer layers and polymer/membrane composite films and neutron Reflectivity as a new tool to study the self assembly of membrane associated proteins.

Selected bibliography

Along with Reinhard Lipowsky, he has authored "the Structure and Dynamics of Membranes". Recently, along with Rudolf Merkel, he has published "Lehrbuch der Biophysik" – a text book on biophysics aimed at students and researchers.

Awards and honors

He was elected a Fellow of the American Physical Society in 2002. [8] In recognition of his research work, in 2006, he was awarded the Stern-Gerlach-Medal by the DPG, German Physical Society.

See also

References

  1. ^ a b Sackmann, E.; Smith, A. S. A. (2014). "Physics of cell adhesion: Some lessons from cell-mimetic systems". Soft Matter. 10 (11): 1644–59. Bibcode:2014SMat...10.1644S. doi:10.1039/C3SM51910D. PMC 4028615. PMID 24651316.
  2. ^ Rädler, J.; Sackmann, E. (1993). "Imaging optical thicknesses and separation distances of phospholipid vesicles at solid surfaces". Journal de Physique II. 3 (5): 727–748. Bibcode:1993JPhy2...3..727R. doi:10.1051/jp2:1993163.
  3. ^ Wiegand, G.; Neumaier, K. R.; Sackmann, E. (1998). "Microinterferometry: Three-Dimensional Reconstruction of Surface Microtopography for Thin-Film and Wetting Studies by Reflection Interference Contrast Microscopy (RICM)". Applied Optics. 37 (29): 6892–905. Bibcode:1998ApOpt..37.6892W. doi:10.1364/AO.37.006892. PMID 18301506.
  4. ^ Sackmann, E.; Bruinsma, R. F. (2002). "Cell Adhesion as Wetting Transition?". ChemPhysChem. 3 (3): 262–9. doi:10.1002/1439-7641(20020315)3:3<262::AID-CPHC262>3.0.CO;2-U. PMID 12503172.
  5. ^ Limozin, L.; Roth, A.; Sackmann, E. (2005). "Microviscoelastic Moduli of Biomimetic Cell Envelopes". Physical Review Letters. 95 (17): 178101. Bibcode:2005PhRvL..95q8101L. doi:10.1103/PhysRevLett.95.178101. PMID 16383873.
  6. ^ Uhde, J; Feneberg, W; Ter-Oganessian, N; Sackmann, E; Boulbitch, A (2005). "Osmotic force-controlled microrheometry of entangled actin networks". Physical Review Letters. 94 (19): 198102. Bibcode:2005PhRvL..94s8102U. doi:10.1103/PhysRevLett.94.198102. PMID 16090216.
  7. ^ Dichtl, M. A.; Sackmann, E. (2002). "Microrheometry of semiflexible actin networks through enforced single-filament reptation: Frictional coupling and heterogeneities in entangled networks". Proceedings of the National Academy of Sciences. 99 (10): 6533–6538. Bibcode:2002PNAS...99.6533D. doi:10.1073/pnas.052432499. PMC 124437. PMID 11997438.
  8. ^ "APS Fellow Archive". APS. Retrieved 17 September 2020.
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