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== Biography ==
== Biography ==


Irwin earned his [[Ph.D.]] in [[organic chemistry]] under the supervision of [[Jack D. Dunitz]] at [[ETH Zurich]] in 1991.<ref>{{cite web |title=The Cambridge Structural Database as a new scientific tool |url=https://www.research-collection.ethz.ch/handle/20.500.11850/140500 |access-date=2024-07-27}}</ref> He worked at a molecular modeling start-up before joining [[Gérard Bricogne]]'s team at the [[MRC Laboratory of Molecular Biology]], where he developed software for macromolecular crystallographic structure solution and refinement, including the BUSTER and SHARP programs.<ref>{{cite web |title= New improved interface now available for SHARP |url=http://www.ysbl.york.ac.uk/ccp4bb/15jun2001/msg00022.html |access-date=2024-07-27}}</ref> Irwin later served as a staff scientist at the [[European Bioinformatics Institute]] (EMBL-EBI) in [[Cambridge]]. In 2000, he moved to the [[Northwestern University Feinberg School of Medicine|Northwestern University Medical School]]. He later moved to the UCSF Department of [[Pharmaceutical Chemistry]]. Since then, he has worked on the development of [[DOCK]]<ref>{{cite web |title=A practical guide to large-scale docking |url=https://www.nature.com/articles/s41596-021-00597-z |journal=Nature |date=2021|access-date=2024-07-26}}</ref>, [[ZINC database|ZINC]]<ref>{{cite journal |title=ZINC: A Free Tool to Discover Chemistry for Biology |url=https://pubs.acs.org/doi/10.1021/ci3001277 |journal=Journal of Chemical Information and Modeling |date=2012}}</ref>, and the [[similarity ensemble approach|similarity ensemble approach (SEA)]]<ref>{{cite journal |title=Quantifying the relationships among drug classes |url=https://www.nature.com/articles/nature08506 |journal=Nature |date=2009}}</ref>. <ref>{{cite web |title=John J. Irwin's ORCID profile |url=https://orcid.org/0000-0002-1195-6417 |access-date=2024-07-27}}</ref>
Irwin earned his [[Ph.D.]] in [[organic chemistry]] under the supervision of [[Jack D. Dunitz]] at [[ETH Zurich]] in 1991.<ref>{{cite web |title=The Cambridge Structural Database as a new scientific tool |url=https://www.research-collection.ethz.ch/handle/20.500.11850/140500 |access-date=2024-07-27}}</ref> He worked at a molecular modeling start-up before joining [[Gérard Bricogne]]'s team at the [[MRC Laboratory of Molecular Biology]], where he developed software for macromolecular crystallographic structure solution and refinement, including the BUSTER and SHARP programs.<ref>{{cite web |title= New improved interface now available for SHARP |url=http://www.ysbl.york.ac.uk/ccp4bb/15jun2001/msg00022.html |access-date=2024-07-27}}</ref> Irwin later served as a staff scientist at the [[European Bioinformatics Institute]] (EMBL-EBI) in [[Cambridge]]. In 2000, he moved to the [[Northwestern University Feinberg School of Medicine|Northwestern University Medical School]]. He later moved to the UCSF Department of [[Pharmaceutical Chemistry]], where he uses virtual screening to find ligands for biological targets.<ref>{{cite web |title=$25 million federal defense grant funds anesthesia innovation |url=https://pharmacy.ucsf.edu/news/2024/07/25-million-federal-defense-grant-funds-anesthesia-innovation |access-date=2024-07-30}}</ref><ref>{{cite web |title=‘Virtual Pharmacology’ Yields Unprecedented Biological Clock Breakthrough |url=https://www.ucsf.edu/news/2020/02/416636/virtual-pharmacology-yields-unprecedented-biological-clock-breakthrough |access-date=2024-07-30}}</ref> Since then, he has worked on the development of [[DOCK]]<ref>{{cite web |title=A practical guide to large-scale docking |url=https://www.nature.com/articles/s41596-021-00597-z |journal=Nature |date=2021|access-date=2024-07-26}}</ref>, [[ZINC database|ZINC]]<ref>{{cite journal |title=ZINC: A Free Tool to Discover Chemistry for Biology |url=https://pubs.acs.org/doi/10.1021/ci3001277 |journal=Journal of Chemical Information and Modeling |date=2012}}</ref>, and the [[similarity ensemble approach|similarity ensemble approach (SEA)]]<ref>{{cite journal |title=Quantifying the relationships among drug classes |url=https://www.nature.com/articles/nature08506 |journal=Nature |date=2009}}</ref>. <ref>{{cite web |title=John J. Irwin's ORCID profile |url=https://orcid.org/0000-0002-1195-6417 |access-date=2024-07-27}}</ref>


== References ==
== References ==

Revision as of 21:33, 30 July 2024

  • Comment: All of the citations are primary sources, which do not show notability. -- NotCharizard 🗨 10:49, 28 July 2024 (UTC)
John Joseph Irwin
Born(1963-05-13)May 13, 1963
Education
Known for
Scientific career
FieldsComputational chemistry
Institutions
Thesis "The Cambridge Structural Database as a new scientific tool"  (1991)
Doctoral advisorJack Dunitz

John J. Irwin is a Canadian computational chemist and an associate professor in the Department of Pharmaceutical Chemistry at the University of California, San Francisco. He specializes in the development of drug design methods using both structure-based and ligand-based approaches. Irwin has contributed to several projects and collaborations in the field of computational chemistry.

Biography

Irwin earned his Ph.D. in organic chemistry under the supervision of Jack D. Dunitz at ETH Zurich in 1991.[1] He worked at a molecular modeling start-up before joining Gérard Bricogne's team at the MRC Laboratory of Molecular Biology, where he developed software for macromolecular crystallographic structure solution and refinement, including the BUSTER and SHARP programs.[2] Irwin later served as a staff scientist at the European Bioinformatics Institute (EMBL-EBI) in Cambridge. In 2000, he moved to the Northwestern University Medical School. He later moved to the UCSF Department of Pharmaceutical Chemistry, where he uses virtual screening to find ligands for biological targets.[3][4] Since then, he has worked on the development of DOCK[5], ZINC[6], and the similarity ensemble approach (SEA)[7]. [8]

References

  1. ^ "The Cambridge Structural Database as a new scientific tool". Retrieved 2024-07-27.
  2. ^ "New improved interface now available for SHARP". Retrieved 2024-07-27.
  3. ^ "$25 million federal defense grant funds anesthesia innovation". Retrieved 2024-07-30.
  4. ^ "'Virtual Pharmacology' Yields Unprecedented Biological Clock Breakthrough". Retrieved 2024-07-30.
  5. ^ "A practical guide to large-scale docking". Nature. 2021. Retrieved 2024-07-26.
  6. ^ "ZINC: A Free Tool to Discover Chemistry for Biology". Journal of Chemical Information and Modeling. 2012.
  7. ^ "Quantifying the relationships among drug classes". Nature. 2009.
  8. ^ "John J. Irwin's ORCID profile". Retrieved 2024-07-27.
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