Fusion gene: Difference between revisions
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A '''fusion gene''' is a hybrid gene formed from two previously separate genes. It can occur as the result of a [[Chromosomal translocation|translocation]], [[interstitial deletion]], or [[chromosomal inversion]]. Often, fusion genes are [[oncogene]]s; examples include [[Philadelphia chromosome|BCR-ABL]], [[FIG-ROS]], and [[TEL-JAK2]]. |
A '''fusion gene''' is a hybrid gene formed from two previously separate genes. It can occur as the result of a [[Chromosomal translocation|translocation]], [[interstitial deletion]], or [[chromosomal inversion]]. The fusion of two genes is often taken as evidence that these genes have related functions[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=165481]. Often, fusion genes are [[oncogene]]s; examples include [[Philadelphia chromosome|BCR-ABL]], [[FIG-ROS]], and [[TEL-JAK2]]. |
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Biologists may also deliberately create fusion genes for research purposes. For example, by creating a fusion gene of a protein of interest and [[green fluorescent protein]], the protein of interest may be observed in [[cell (biology)|cells]] or [[biological tissue|tissue]] using fluorescence [[microscopy]]. The protein synthesized when a fusion gene is [[gene expression|expressed]] is called a ''[[fusion protein]]''. |
Biologists may also deliberately create fusion genes for research purposes. For example, by creating a fusion gene of a protein of interest and [[green fluorescent protein]], the protein of interest may be observed in [[cell (biology)|cells]] or [[biological tissue|tissue]] using fluorescence [[microscopy]]. The protein synthesized when a fusion gene is [[gene expression|expressed]] is called a ''[[fusion protein]]''. |
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Revision as of 16:10, 20 May 2007
A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion. The fusion of two genes is often taken as evidence that these genes have related functions[1]. Often, fusion genes are oncogenes; examples include BCR-ABL, FIG-ROS, and TEL-JAK2.
Biologists may also deliberately create fusion genes for research purposes. For example, by creating a fusion gene of a protein of interest and green fluorescent protein, the protein of interest may be observed in cells or tissue using fluorescence microscopy. The protein synthesized when a fusion gene is expressed is called a fusion protein.
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