AIDS-related lymphoma: Difference between revisions
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'''AIDS-related lymphoma''' describes [[lymphoma]]s occurring in [[patient]]s with acquired immunodeficiency syndrome ([[AIDS]]). |
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A lymphoma is a type of cancer arising from [[lymphatic system|lymphoid]] [[cell (biology)|cells]]. In AIDS, the incidences of [[non-Hodgkin's lymphoma]], primary [[cerebrum|cerebral]] lymphoma and [[Hodgkin's disease]] are all increased. |
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==Non-Hodgkin's lymphoma== |
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Non-Hogkin's lymphoma (NHL) is present in about 3% of [[HIV]] positive people at the time of their diagnosis of HIV. 20% of HIV positive patients will develop NHL. |
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==Primary cerebral lymphoma== |
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Primary cerebral lymphoma (or ''primary central nervous system lymphoma'') is a form of NHL. It is very rare in [[immunocompetent]] people, with an incidence of 5-30 cases per million person-years. However the incidence in [[immunocompromise]]d individuals is greatly increased, up to 100 per million person-years. |
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Primary cerebral lymphoma is strongly associated with [[Epstein-Barr virus]] (EBV). The presence of EBV [[DNA]] in [[cerebrospinal fluid]] is highly suggestive of primary cerebral lymphoma. |
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Treatment of AIDS patients with [[antiretroviral drug]]s reduces the incidence of primary cerebral lymphoma. |
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==Hodgkin's disease== |
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The incidence of Hodgkin's disease in the general population is about 10-30 per million person-years. This increases to 170 per million person-years in HIV positive patients. |
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==Reference== |
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*Rigolet A, Bossi P, Caumes E, Agher R, Zeller V, Katlama C, Bricaire F. ''Caracteristiques epidemiologiques et evolution de l'incidence des lymphomes cerebraux primitifs observes chez 80 patients infectes par le VIH entre 1983 et 1999.'' Pathol Biol (Paris) 2001;49:572-5. PMID 11642021 |
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==See also== |
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* [[AIDS]] |
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* [[Non-Hodgkin's lymphoma]] |
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* [[Hodgkin's disease]] |
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[[Category:HIV/AIDS]] |
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[[Category:Hematology]] |
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[[Category:Oncology]] |
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Revision as of 17:44, 27 August 2005
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