Survival of motor neuron: Difference between revisions
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'''Survival of motor neuron''' is a protein associated with [[spinal muscular atrophy]]. |
'''Survival of motor neuron''' (SMN) is a protein associated with [[spinal muscular atrophy]]. |
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A 2004 study using [[high-throughput screening]] found [[indoprofen]] to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for [[spinal muscular atrophy|spinal muscular atrophies]].<ref>{{cite journal |author=Lunn MR, Root DE, Martino AM, ''et al'' |title=Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism |journal=Chem Biol |volume=11 |issue=11 |pages=1489–93 |year=2004 |pmid=15555999 |doi=10.1016/j.chembiol.2004.08.024}}</ref> |
A 2004 study using [[high-throughput screening]] found [[indoprofen]] to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for [[spinal muscular atrophy|spinal muscular atrophies]].<ref>{{cite journal |author=Lunn MR, Root DE, Martino AM, ''et al'' |title=Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism |journal=Chem Biol |volume=11 |issue=11 |pages=1489–93 |year=2004 |pmid=15555999 |doi=10.1016/j.chembiol.2004.08.024}}</ref> |
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Later research show a possible role of SMN in neuronal migration and/or differentiation <ref>http://cat.inist.fr/?aModele=afficheN&cpsidt=17713178</ref>. |
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==See also== |
==See also== |
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Revision as of 19:20, 24 November 2008
| survival of motor neuron 1, telomeric | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SMN1 | ||||||
| Alt. symbols | SMA@, SMA | ||||||
| NCBI gene | 6606 | ||||||
| HGNC | 11117 | ||||||
| OMIM | 600354 | ||||||
| RefSeq | NM_000344 | ||||||
| UniProt | Q16637 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q13 | ||||||
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| survival of motor neuron 2, centromeric | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SMN2 | ||||||
| NCBI gene | 6607 | ||||||
| HGNC | 11118 | ||||||
| OMIM | 601627 | ||||||
| RefSeq | NM_017411 | ||||||
| UniProt | Q16637 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q13 | ||||||
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Survival of motor neuron (SMN) is a protein associated with spinal muscular atrophy.
A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1]
Later research show a possible role of SMN in neuronal migration and/or differentiation [2].
See also
References
- ^ Lunn MR, Root DE, Martino AM; et al. (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol. 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMID 15555999.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ http://cat.inist.fr/?aModele=afficheN&cpsidt=17713178
External links
- SMN+protein+(spinal+muscular+atrophy) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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