DNA repair protein XRCC4: Difference between revisions
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| summary_text = The [protein] encoded by this gene functions together with [[LIG4|DNA ligase IV]] and the DNA-dependent [[protein kinase]] in the [[DNA repair|repair]] of [[DNA]] double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7518| accessdate = }}</ref> |
| summary_text = The [[protein]] encoded by this gene functions together with [[LIG4|DNA ligase IV]] and the DNA-dependent [[protein kinase]] in the [[DNA repair|repair]] of [[DNA]] double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7518| accessdate = }}</ref> |
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Revision as of 02:54, 26 February 2009
Template:PBB X-ray repair complementing defective repair in Chinese hamster cells 4, also known as XRCC4, is a human gene.[1]
References
Further reading
External links
- XRCC4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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