Satratoxin-H: Difference between revisions
Content deleted Content added
{{Chembox new --> {{Chembox, Replaced: {{chembox new → {{chembox using AWB |
←Blanked the page |
||
| Line 1: | Line 1: | ||
{{chembox |
|||
| ImageFile = Satratoxin-H.svg |
|||
| ImageSize = 170px |
|||
| IUPACName = <small>(2'R,4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR,25R)-6,7,16,16a,19a,22- |
|||
hexahydro-25-hydroxy-9-((1S)-1-hydroxyethyl)-16a,21-dimethyl-spiro(5,9,16,18-dimethano- |
|||
1H,3H,23H-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyran-17(18H)-2'-oxirane)- |
|||
3,14(9H)-dione</small> |
|||
| OtherNames = |
|||
| Section1 = {{Chembox Identifiers |
|||
| CASNo=53126-64-0 |
|||
| PubChem=6438478 |
|||
| SMILES = CC1=CC2C3(CC1)COC(=O)C=C4CCOC(C4O)(C=CC=CC(=O)OC5C3(C6(CO6)C(C5)O2)C)C(C)O}} |
|||
| Section2= {{Chembox Properties |
|||
| Formula=C<sub>29</sub>H<sub>36</sub>O<sub>9</sub> |
|||
| MolarMass=528.591 |
|||
| Appearance= |
|||
| Density= |
|||
| MeltingPt= |
|||
| BoilingPt= |
|||
| Solubility=}} |
|||
| Section3= {{Chembox Hazards |
|||
| MainHazards= |
|||
| FlashPt= |
|||
| Autoignition=}} |
|||
}} |
|||
'''Satratoxin-H''', a [[trichothecene]] [[mycotoxin]], is a naturally occurring [[mold]] byproduct of ''[[Stachybotrys chartarum]]'' which is toxic to humans and animals. The clinical condition it causes is known as ''Stachybotrotoxicosis''. It is related to the mycotoxin [[T-2 mycotoxin|T-2]], but unlike T-2 has not been reported to have been used as a [[biological weapon]]. |
|||
== Properties == |
|||
Satratoxin-H is almost completely insoluble in water, but is easily soluble in lower alcohols and polar solvents such as [[ethanol]], [[methanol]], [[isopropanol]] (rubbing alcohol), [[acetone]] and [[chloroform]].<ref>[http://www.cbwinfo.com/Biological/Toxins/Satra.html Satratoxin H:essential data]</ref> |
|||
Satratoxin-H is not officially classified as a [[chemical weapon]]. |
|||
== Effects == |
|||
Satratoxin-H is extremely versatile. Contact with the solution through ingestion, inhalation, or even physical contact produces symptoms similar to those listed below. |
|||
* a rash that becomes a moist dermatitis |
|||
* nosebleeds |
|||
* chest pain |
|||
* pulmonary hemorrhage (bleeding in the lungs) |
|||
* hyperthermia (raised temperature) |
|||
* headache |
|||
* fatigue |
|||
However, if consumed in large quantities, it can be lethal. Satratoxin-H has little effect on bare skin, and does not blister in the way many chemical weapons do. However, upon sensitive surfaces (eyes, interior of mouth or nose), it can irritate the skin or cause a rash. |
|||
The toxicology of satratoxin-H shows that it has an [[LD50|LD<sub>50</sub>]] for mice of 1.0 - 1.4 mg/kg, upon injection. Otherwise it is reported to be about five times as toxic as the T-2 toxin.<ref>[http://mason.gmu.edu/~pdonovan/Chem_350/Toxin.html#5Satratoxin-H, A mycotoxin with punch!]</ref> |
|||
== References == |
|||
{{cleanup-references}} |
|||
{{reflist}} |
|||
* Croft. W.A., Jarvis, B.B., and Yatawara, C.S. 1986. Airborne outbreak of trichothocene toxicosis. Atmos. Environ. 20:549-552. |
|||
* Effects of Intranasal Exposure to Spores of Stachybotrys atrain Mice*1, Fundamental and Applied Toxicology, Volume 35, Issue 2, February 1997, Pages 182-188 Marjo Nikulin, Kari Reijula, Bruce B. Jarvis, Pirjo Veijalainen and Eeva-Liisa Hintikka |
|||
[[Category:Mycotoxins]] |
|||
[[de:Satratoxin]] |
|||
[[it:Satratossina-H]] |
|||