TAR DNA-binding protein 43: Difference between revisions
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'''TAR DNA binding protein''', also known as '''TARDBP''' or as '''TDP-43''', is a [[ |
'''TAR DNA binding protein''', also known as '''TARDBP''' or as '''TDP-43''', is a [[Cell_(biology)|cellular]] [[protein]].<ref>[http://www.ncbi.nlm.nih.gov/pubmed/7745706 Cloning and characterization of a novel cellular p...[J Virol. 1995] - PubMed Result<!-- Bot generated title -->]</ref> It is one of the [[genes]] on [[chromosome 1]]. Pathology in this protein has been linked to a couple of diseases, such as frontotemporal lobar degeneration and motor neuron disease.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/17492294 TDP-43 proteinopathy: the neuropathology underlyin...[Acta Neuropathol. 2007] - PubMed Result<!-- Bot generated title -->]</ref> |
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===TARDBP and HIV=== |
===TARDBP and HIV=== |
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Revision as of 18:57, 26 March 2009
Template:PBB TAR DNA binding protein, also known as TARDBP or as TDP-43, is a cellular protein.[1] It is one of the genes on chromosome 1. Pathology in this protein has been linked to a couple of diseases, such as frontotemporal lobar degeneration and motor neuron disease.[2]
TARDBP and HIV
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.[3]
References
Further reading
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