Talk:Alpha-1 antitrypsin deficiency: Difference between revisions
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Professor of Medicine |
Professor of Medicine |
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National Jewish Health <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Ssandhaus|Ssandhaus]] ([[User talk:Ssandhaus|talk]] • [[Special:Contributions/Ssandhaus|contribs]]) 18:00, 13 June 2009 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot--> |
National Jewish Health <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Ssandhaus|Ssandhaus]] ([[User talk:Ssandhaus|talk]] • [[Special:Contributions/Ssandhaus|contribs]]) 18:00, 13 June 2009 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot--> |
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== Michael Jackson was said to have Alpha-1 antitrypsin deficiency == |
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One of my sources suggested that he might already have had a genetic condition I had never previously come across, called Alpha-1 antitrypsin deficiency – the lack of a protein that can help protect the lungs. |
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Although up to 100,000 Americans are severely affected by it, it is an under-recognised condition. Michael was receiving regular injections of Alpha-1 antitrypsin derived from human plasma. The treatment is said to be remarkably effective and can enable the sufferer to lead a normal life. |
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But the disease can cause respiratory problems and, in severe cases, emphysema. Could this be why Jackson had for years been wearing a surgical mask in public, to protect his lungs from the ravages of the disease? Or why, from time to time, he resorted to a wheelchair? When I returned to my source inside the Jackson camp for confirmation, he said: ‘Yeah, that’s what he’s got. He’s in bad shape. They’re worried that he might need a lung transplant but he may be too weak. |
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- Ian Halperin, 28th June 2009 |
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http://www.dailymail.co.uk/news/article-1196009/Im-better-dead-Im-How-Michael-Jackson-predicted-death-months-ago.html |
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Revision as of 12:56, 28 June 2009
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This article is supported by the WikiProject on Medical genetics, which gives a central approach to Medical genetics and related subjects on Wikipedia. Please participate by editing the article Alpha-1 antitrypsin deficiency, or visit the project page for more details on the projects. |
| B | This article has been rated as B-Class on the quality scale. |
Alpha 1-antitrypsin deficiency is not due to amyloid (as stated in this article). The proteins deposited within liver Cells do not have the characteristics of amyloid.
- Correct. It is, however, accumulated protein. I'll change the article to fit this. PS Get a username and put your knowledge to use!! We'd love to have you! JFW | T@lk 19:14, 24 May 2004 (UTC)
allergys
do allergys make alpha1 worse since the allergen has to get destroyed? —The preceding unsigned comment was added by 75.146.18.113 (talk) 01:33, August 24, 2007 (UTC)
listings
Why does it list both COPD and emphysema, when emphysema is a subgroup of COPD?
Incorrect information in this article
The information in this article (Alpha 1-Antitrypsin Deficiency) contains significant misinformation. The section towards the end includes the medical recommendation that individuals with this condition take paracetamol (aka acetaminophen or Tylenol) at the least provocation because it will reduce the accumulation of protein within the liver. There is absolutely no evidence to support this and, in fact, there is growing concern that even recommended doses of acetaminophen or paracetamol can be toxic to the liver. I have edited this section of the article on several occasions and each time, within hours of the edit a program or person named Smackbot re-edits it back to the original version. I can only assume this is a misinformed patient or, worse, a manufacturer of paracetamol behind this potentially dangerous misinformation.
Robert Sandhaus, MD, PhD Clinical Director, Alpha-1 Foundation Professor of Medicine National Jewish Health —Preceding unsigned comment added by Ssandhaus (talk • contribs) 18:00, 13 June 2009 (UTC)
Michael Jackson was said to have Alpha-1 antitrypsin deficiency
=
One of my sources suggested that he might already have had a genetic condition I had never previously come across, called Alpha-1 antitrypsin deficiency – the lack of a protein that can help protect the lungs.
Although up to 100,000 Americans are severely affected by it, it is an under-recognised condition. Michael was receiving regular injections of Alpha-1 antitrypsin derived from human plasma. The treatment is said to be remarkably effective and can enable the sufferer to lead a normal life.
But the disease can cause respiratory problems and, in severe cases, emphysema. Could this be why Jackson had for years been wearing a surgical mask in public, to protect his lungs from the ravages of the disease? Or why, from time to time, he resorted to a wheelchair? When I returned to my source inside the Jackson camp for confirmation, he said: ‘Yeah, that’s what he’s got. He’s in bad shape. They’re worried that he might need a lung transplant but he may be too weak.
- Ian Halperin, 28th June 2009