Talk:Angiogenesis

Proper Terminology and Mechanisms

I am studying microvasculature remodeling as a result of exercise at the University of Virginia and noticed that this page was lacking in general mechanisms of angiogenesis. Angiogenesis refers only to the changes in capillaries, just a terminology issue. I have outlined many of the chemical mechanisms relating to angiogenesis. Xwingjedi14 06:50, 14 December 2005 (UTC)

How important is an increased tumor cell mutation rate?

There are some good examples of increased mutation rate in certain cancers, but I am not sure that it has been established that a high mutation rate is required for angiogenesis.

The article Genetic instability and the evolution of angiogenic tumor cell lines (review) claims support from mathematical models for the idea that faster mutation is important.

Other articles such as Angiogenesis and the role of epigenetics in metastasis seem to point towards a need to investigate a combination of mutational and epigenetic mechanisms.

A recent review article Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention says: "The challenges ahead are to define the number of genetic hits necessary for conversion of a normal cell into a cancer cell and to determine whether the observed increase in the mutation rate (mutator phenotype) is required."

Is there really any data on the role of tumor cell mutation rate in angiogenesis?

Removed reference to evolution at cellular level. This is impossible (how are the selected changes to be passed to the next generation?), evolution only occurs in populations of whole organisms. Try to use more accurate terminology please.--Alun 07:37, 29 Apr 2005 (UTC)

New Research Suggests Tumors Engender Development of Metastatic Niche (Angiogenesis) Prior to Actual Metastasis

A recent article in Nature VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche suggests that angiogenesis occurs before metastasis and that the cancer mestasizes to the site of the angiogenisis. guk,o.o,lnve kjf5rtyuiopsdfghjklertyuiop[

DII4

New chemical has been identified at Karolinska Institutet, source: http://www.dn.se/DNet/jsp/polopoly.jsp?d=597&a=611356&rss=1400

should be published in Nature soon.

Nsoltani 19:49, 28 January 2007 (UTC)

I changed the reference to a Nature paper, since the previously supplied reference was in Finnish; this is the English version of Wikipedia, so a reference in Finnish seems inappropriate (or at least not helpful). Gacggt 13:46, 29 March 2007 (UTC)

Angiopoietins

Strangely, there was no section on Ang1 or Ang2; so that was added.

Also, some of the less scientific wording was removed ("wanton destruction" etc).

Gacggt 13:01, 29 March 2007 (UTC)

Anti-angiogenesis cancer strategy

There was a claim that Dr. Folkman was the first to coin the term "anti-angiogenesis", and the first to suggest this as an anti-cancer strategy. While Dr. Folkman has been perhaps the best-known and strongest proponent of this strategy, it seems like such strong claims should be referenced before being included. So that sentence was removed pending some proof of the claim. I hope that is all right...

Can someone please provide a reference?

Gacggt 13:00, 29 March 2007 (UTC)

Yes, it is true: In the scientific world, J. Folkman is called the "father of angiogenesis", because he started research on angiogenesis in the 70-ies, mainly focussed on methods to inhibit tumor growth by blocking angiogenesis.

Here are two references: 1. Folkman, J, Klagsbrun, M: Angiogenetic factors. Science 235: 442-447, 1987 2. Folkman J. Fighting cancer by attacking its blood supply. Sci Am. 275:150 –154, 1996

Thomasjst (talk) 17:11, 10 December 2007 (UTC)

angiogenesis & CVD

I added a section about angiogenesis and cardiovascular disease, because that is becoming a more & more growing scientific field, using angiogenesis for new treatment options in CVDs.Thomasjst (talk) 11:24, 17 December 2007 (UTC)

Involvement

"Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels."

Wouldn't it be equally accurate and more informative to say that "angiogenesis is the growth of new blood vessels from existing ones"? Saying what it "involves" fails to disclose what it is. Unfree (talk) 18:20, 17 December 2007 (UTC)

News

According to "Science News" (Dec 8, 2007, p 357), "A new study in mice finds that a protein called Bv8 promotes vessel growth around tumors both directly and by inducing certain marrow cells to migrate out of bone and help tumors form a vessel network. Neutralizing Bv8, or preventing cells from making it, curbs such proliferation, scientists at Genentech in South San Francisco report in the Dec. 6 /Nature/."

(Incidentally, they use the word "metallopeptidase," rather than "metalloproteinase," in "matrix metallopeptidase-9.") Unfree (talk) 18:40, 17 December 2007 (UTC)

Clarification of Acronyms

I think there needs to be a little more clarification of what certain acronyms mean in this page. For instance, in the VEGF section, "NO" is used multiple times. What does it stand for? I don't believe it means "Nitrous Oxide," so it should be explained in some way. —Preceding unsigned comment added by 152.17.57.169 (talk) 18:48, 16 June 2008 (UTC)

References

The references that have been placed in the "Types" section should be relocated to the "References" section. —Preceding unsigned comment added by 59.101.40.74 (talk) 12:32, 17 June 2008 (UTC)

Looping Angiogenesis

The article talks about "sprouting" and "splitting" angiogenesis, recent research shows that these are not the only angiogenic pathways, thus a section on "looping angiogenesis" should be added (although not necessarily by that name) Jezpas (talk) 15:16, 13 March 2010 (UTC)

Light induced Angiogenesis

This page does not mention the use of light at therapeutic frequencies to induce angiogenesis. Stimulation or modulation of tissues with laser and diode light at frequencies (such as 630nm, 808nm and 980nm) will induce angiogenesis. Often cited as a key component of LILT by WALT and others, even papers published on myocardial angiogenesis over the last ten years plus.