Extracerebral decarboxylase inhibitor: Difference between revisions
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Extracerebral decarboxylase inhibitor is an enzyme. It is used to inhibit the metabolism L-DOPA to Dopamine outside the brain, i.e. in the blood. This is primarily co-adminstered with L-DOPA to combat Parkinsons Disease. This also prevents common side-effects of nausea and vomiting as a result of interaction with D2 receptors in the vomiting center (or cheomoreceptor trigger zone) located outside the blood:brain barrier. |
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Inhibits the conversion L-DOPA to Dopamine outside the brain, i.e. in the blood. |
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==References== |
==References== |
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Revision as of 09:36, 19 May 2011
Extracerebral decarboxylase inhibitor is an enzyme. It is used to inhibit the metabolism L-DOPA to Dopamine outside the brain, i.e. in the blood. This is primarily co-adminstered with L-DOPA to combat Parkinsons Disease. This also prevents common side-effects of nausea and vomiting as a result of interaction with D2 receptors in the vomiting center (or cheomoreceptor trigger zone) located outside the blood:brain barrier.
References
Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa. http://www.ncbi.nlm.nih.gov/pubmed/4938431