Microcoria: Difference between revisions
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[[Category:Diseases of the eye and adnexa]] |
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1. Zenker et al., 2004. Zenker M., Aigner T., Wendler O., et al: Human laminin beta 2 deficiency causes congenital nephrosis with mesangial sclerosis and distint eye abnormalities. Hum Mol Genet 2004; 13:2625-2632. |
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Revision as of 04:20, 16 March 2012
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Microcoria is a congenital disease in which the pupils of the subject are narrower than 2mm in diameter. Microcoria is associated with juvenile-onset glaucoma. It is also associated with Pierson syndrome chararacterized by microcoria and congenital nephrotic syndrome. The defect is in the Laminin beta 2 gene on chromosome 3p21 which encodes a protein essential to the glomerular basement membrane [1]. (Zenker et al 2004)
It is also part of the known manifestations of a born infant to a mother suffering from uncontrolled hyperglycemia[citation needed]. Other symptoms include transposition of great vessels, respiratory distress secondary to surfactant defect, sacral agensis, jitteriness, irritability, and lethargy due to rebound fetal hypoglycemia.
References
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1. Zenker et al., 2004. Zenker M., Aigner T., Wendler O., et al: Human laminin beta 2 deficiency causes congenital nephrosis with mesangial sclerosis and distint eye abnormalities. Hum Mol Genet 2004; 13:2625-2632
See also
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