Microcoria: Difference between revisions
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'''Microcoria''' is a [[congenital]] disease in which the [[pupil]]s of the subject are narrower than 2mm in diameter. Microcoria is associated with juvenile-onset [[glaucoma]]. It is also associated with Pierson syndrome chararacterized by microcoria and congenital nephrotic syndrome. The defect is in the Laminin beta 2 gene on chromosome 3p21 which encodes a protein essential to the glomerular basement membrane <ref>1</ref>. |
'''Microcoria''' is a [[congenital]] disease in which the [[pupil]]s of the subject are narrower than 2mm in diameter. Microcoria is associated with juvenile-onset [[glaucoma]]. It is also associated with Pierson syndrome chararacterized by microcoria and congenital nephrotic syndrome. The defect is in the Laminin beta 2 gene on chromosome 3p21 which encodes a protein essential to the glomerular basement membrane <ref>1</ref>. |
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It is also part of the known manifestations of a born infant to a mother suffering from uncontrolled hyperglycemia{{Cn|date=November 2011}}. Other symptoms include transposition of great vessels, respiratory distress secondary to surfactant defect, sacral agensis, jitteriness, irritability, and lethargy due to rebound fetal hypoglycemia. |
It is also part of the known manifestations of a born infant to a mother suffering from uncontrolled hyperglycemia{{Cn|date=November 2011}}. Other symptoms include transposition of great vessels, respiratory distress secondary to surfactant defect, sacral agensis, jitteriness, irritability, and lethargy due to rebound fetal hypoglycemia. |
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Revision as of 04:21, 16 March 2012
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Microcoria is a congenital disease in which the pupils of the subject are narrower than 2mm in diameter. Microcoria is associated with juvenile-onset glaucoma. It is also associated with Pierson syndrome chararacterized by microcoria and congenital nephrotic syndrome. The defect is in the Laminin beta 2 gene on chromosome 3p21 which encodes a protein essential to the glomerular basement membrane [1].
It is also part of the known manifestations of a born infant to a mother suffering from uncontrolled hyperglycemia[citation needed]. Other symptoms include transposition of great vessels, respiratory distress secondary to surfactant defect, sacral agensis, jitteriness, irritability, and lethargy due to rebound fetal hypoglycemia.
== References ==
- ^ 1
Zenker et al., 2004. Zenker M., Aigner T., Wendler O., et al: Human laminin beta 2 deficiency causes congenital nephrosis with mesangial sclerosis and distint eye abnormalities. Hum Mol Genet 2004; 13:2625-2632
See also
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