Talk:Small nuclear RNA: Difference between revisions

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Id be keen to have 'small nucleolar RNA' re-instated as a full page again rather than a re-direct merged with small nucleolar RNA? Jennifer_Rfm 12:52, 15 June 2007 (UTC)[reply]

This has been done: Small nucleolar RNA. Biolprof (talk) 19:04, 7 February 2013 (UTC)[reply]

images

If anyone has some nice labelled images of C/D box or H/ACA box structures please do substitute them for the ones I have added Jennifer_Rfm 14:58, 15 June 2007 (UTC)[reply]

course project

I will be improving this page as part of a class project under the supervision of Dr. Lesly Temesvari (Username:LTEMESV) at Clemson University. (Bjstone6 (talk) 14:19, 16 November 2012 (UTC))[reply]

All the statements made in this article should contain references to (at the very least) peer edited reviews in the field. —Preceding unsigned comment added by 128.100.134.71 (talk) 21:55, 3 March 2008 (UTC)[reply]

updates needed

The article makes at least two claims which need to be corrected.

That splicing is effected post-transcriptionally. The current consensus is that it is primarily co-transcriptional but some of it takes place post-transcriptionally.
(Goldstrohm, Aaron C., Arno L. Greenleaf, and Mariano A. Garcia-Blanco. "Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing." Gene 277.1 (2001): 31-47.)
That the distinction between U2-type and U12-type introns is the consensus sequence at the 5' and 3' splice sites. This is a relic of the initial discovery of the minor spliceosome. This is why the minor spliceosome analogue to the U4/U6 snRNA duplex has 'atac' appended i.e. U4atac and U6atac. This is not necessarily the case and there are several U2-types with AT-AC as well as U12-types with GT-AG (Levine, Aaron, and Richard Durbin. "A computational scan for U12-dependent introns in the human genome sequence." Nucleic acids research 29.19 (2001): 4006-4013; Sheth, Nihar, et al. "Comprehensive splice-site analysis using comparative genomics." Nucleic acids research 34.14 (2006): 3955-3967.).

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 All the statements made in this article should contain references to (at the very least) peer edited reviews in the field.  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/128.100.134.71|128.100.134.71]] ([[User talk:128.100.134.71|talk]]) 21:55, 3 March 2008 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->
+==updates needed==
+The article makes at least two claims which need to be corrected.
+* That splicing is effected ''post-transcriptionally''. The current consensus is that it is primarily co-transcriptional but some of it takes place post-transcriptionally.
+* (Goldstrohm, Aaron C., Arno L. Greenleaf, and Mariano A. Garcia-Blanco. "Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing." Gene 277.1 (2001): 31-47.)
+* That the distinction between U2-type and U12-type introns is the consensus sequence at the 5' and 3' splice sites. This is a relic of the initial discovery of the minor spliceosome. This is why the minor spliceosome analogue to the U4/U6 snRNA duplex has 'atac' appended i.e. U4atac and U6atac. This is not necessarily the case and there are several U2-types with AT-AC as well as U12-types with GT-AG (Levine, Aaron, and Richard Durbin. "A computational scan for U12-dependent introns in the human genome sequence." Nucleic acids research 29.19 (2001): 4006-4013; Sheth, Nihar, et al. "Comprehensive splice-site analysis using comparative genomics." Nucleic acids research 34.14 (2006): 3955-3967.).