Histamine H2 receptor: Difference between revisions
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==External links== |
==External links== |
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*[http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2305 IUPHAR |
*[http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2305 IUPHAR GPCR Database - H<sub>2</sub> Histamine Receptor] |
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[[Category:G protein coupled receptors]] |
[[Category:G protein coupled receptors]] |
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Revision as of 12:35, 1 August 2006
H2 receptors positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP[[1]] production. It increases the intracellular Ca2+ concentrations and release Ca2+ from intracellular stores.
The drug Betazole is an example of a Histamine H2 receptor agonist.
Location
- Gastric parietal cells (oxyntic cells)
- Vascular smooth muscle
- Neutrophils
- Central nervous system
- Heart
- Uterus
Reponse
- Stimulation of gastric acid secretion
- Smooth muscle relaxation
- Inhibit antibody synthesis, T-cell proliferation and cytokine production
H2-receptor agonists and antagonists
see H2-receptor agonist and H2-receptor antagonist