Talk:EAST syndrome

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): BCBF13, Jmankow, Sydneym21, ErikEastwood (article contribs).

Overall well written! I thought the article was very informative; one section that could be explained further was the process of how exactly seizures occur. Hmarie18 (talk) 20:57, 16 April 2016

Primary Review

I feel like the article was very well written. The explanation of Epilepsy, Ataxia, Sensorineural Deafness and Tubulopathy are descriptive enough for a reader to understand exactly what each symptom contributes to the syndrome. It was also very helpful to state that KCNJ10 is the gene that is mutated before describing the other symptoms to help illustrate how each symptom is caused. One suggestion that I would offer is to see if you could find an animation figure of the gene, or some other type of image to your page to help strengthen it. The image on the page for Epilepsy and Sensorineural Deafness are both good images I think you could use. I would agree with the secondary review that the management section does not seem necessary, and could be removed. The article KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function, was a very good and credible article to use, and it seems like it was cited properly within your article. (AKon10 (talk) 00:33, 20 April 2016 (UTC)) — Preceding unsigned comment added by AKon10 (talk • contribs) 21:55, 18 April 2016 (UTC)

Primary Review

Most of the article does a good job explaining specific details and making it easier for the reader to understand complicated words. However, this can be done better. For example, the mutations part of the page is very specific and hard to understand and follow. Also in the tubulopathy section I get lost and confused. By explaining in more detail on the specifics like for example this sentence “In addition to diminishing Na+/K+ - ATPase’s inadequate KCNJ10 functioning leads to depolarization of the basolateral membrane which reduces electro genic transporters driving force”. One could explain briefly what the basolateral membrane is and does. There is a wiki link on basolateral, but explaining just briefly will help readers get a better understanding of what is actually occurring in tubulopathy. Overall, the article was well written and neutral. If there was a picture describing what is happening in the kidneys in tubulopathy that would help the reader get a better comprehension of the situation. Opposed from the few confusing parts the article does a great job describing what EAST syndrome is. The article  "The salt- wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel", was a good article and well cited. Leaving out confusing parts of the article and including the necessary detail for readers to get an overall understanding of tubulopathy was done well. --Ewiegand (talk) 21:31, 19 April 2016 (UTC)

Secondary Review

Overall, I thought this article was very well done, covered a wide range of topics, and specifically explained the hard science behind the mechanisms that cause the symptoms of the disease. First, I think the Management section could just be deleted since it does not really offer anything extremely significant at this point. I would just mention near the end of the introductory paragraph that potential cures/ways to manage the disease are being researched. I would also check for experiments done on KCNJ10 (if you have not done so already) and see what variances in the presence of EAST syndrome and in the various symptoms would occur if some of the variables were changed and other experiments were done. I would also try and see if there is a picture of the KCNJ10 gene, in order to specifically show the different gene locus that define the various symptoms.

Mmaggay (talk) 14:48, 18 April 2016 (UTC)mmaggay

Secondary Review

Overall well done!- I liked how the authors went in to detail of each part of the syndrome as well as the management and treatment. I also appreciated an explanation on how these mutations affect the mechanisms in the body such as potassium channels. This is something many articles on Wikipedia fail to do. The mechanisms are also explained in simple enough language for the general public to understand. I would suggest adding a picture if one is available. Another recommendation I would make is deleting “but hopefully with continued research, there could be one day” which is at the very end of the article. While the optimism is great, I feel like this may be adding too much of the author’s voice in an encyclopedia article.9260konetzf (talk) 22:59, 19 April 2016 (UTC)

Secondary Review

I thought the article page was very well written. The authors did a great job at explaining the details of how the KCNJ10 gene mutation causes each of the symptoms associated with the syndrome in a way that the general public could understand. I would recommend either deleting the management section as a whole, as it contains editor bias and does not really contribute any major information necessary to understand the disease. Another option may be to add a few potential options (if any available) they have found to at least reduce the symptoms associated with the syndrome. I would also recommend deleting the word necessarily in the prevention/screening section, as it does not explain how it could potentially be prevented, and kind of appears to imply author bias. Overall great job! Dassowsd (talk) 01:21, 20 April 2016 (UTC)

Secondary Source by Jxl579

The article was very well written and well organized. I liked how each symptom for EAST syndrome had its own section and how the mutation of the KCNJ10 plays a role in each of the different symptoms. Certain scientific terms were clarified by using a hyperlink or a brief description within parentheses. This would be helpful for anyone who is not familiar with scientific jargon. If there are any pictures of KCNJ10, that would be a helpful reference or even in the section regarding deafness, an image of the affected ear pathway might be helpful as well. Finally, maybe under the management section, discuss if there are any current findings regarding research on EAST syndrome. Overall, well done! Jxl579 (talk) 03:56, 20 April 2016 (UTC)

§== Primary Review ==

Overall there is nice informative start to the article. Having a slight definition of each consisting part of the syndrome gives the reader a decent insight of what the syndrome can do. Digging deeper into the article I like how informative it is and how specific the details are. However they may be to specific in the mutations category, I like the information coming from a student standpoint but I can see as a regular wiki user how this part of the article may get skimmed over just because of the scientific background needed to get a grasp on the concept. Having references to other diseases that are related to EAST syndrome is a nice touch to have – this allows the reader to dig into further articles if this specific topic enthuses them. I checked the sourcing for, “ Reichold, M.; A., Z.; L, E.; Rapedius, M.; K, R.; B, D.; Warth, R. "KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function".US National Library of Medicine National Institutes of Health. Retrieved 11 April 2016.” In this regard they checked out with referencing/sourcing. A few other adjustments I would make to the article would involve hyperlinking “Bockenhaur and co-workers” as it presents the finders of the subject out of no where and could allow the reader to find more information about the topic. In the different symptoms category I would delete the initial sentences stating the acronym - “Tubulopathy is represented by the T in the acronym EAST syndrome”. As a reader I feel that it is unnecessary information to include. There should be an image present somewhere within the confines of the page to allow for a visual representation. My suggestion is to insert an image or two within the symptoms sections that way the reader can visualize the physical symptoms present. Finally, In the 2nd paragraph I would lay off the use of parentheses and construct a complete sentence such as the following; Affecting the K+ channels in the brain, ear and kidney the KCNJ10 gene encodes K+ to flow into a cell rather than out. With these changes I feel that the article would be even better! — Preceding unsigned comment added by Gilbertoenriquez (talk • contribs) 11:44, 20 April 2016 (UTC)

Secondary Review

I believe your article describes EAST syndrome quite well. I like how you organized the symptoms of EAST syndrome into paragraphs that described the symptom that coincided with the acronym in the order of EAST. You seem to site your sources well, but also do a good job in putting in your own explanation. I do have a few suggestions for your article. One is that in your intro, you use a lot of parentheses for clarifying the aforementioned symptom and/or what a word means. I think it might look cleaner if you delete these small parenthetical interjections and expound upon them in your descriptions within the symptoms section. In addition, you can also add to your “mutations” section by clarifying the type of mutation that occurs in EAST syndrome (i.e. you can state that it’s a “point mutation” of R65P vs. a frameshift or nonsense mutation). Finally, I think a picture of the KCNJ10 channel may be beneficial to add into your mutations section if you are able to find it. Overall, I like the layout of your article, and I feel like I have learned many things about EAST syndrome. Please reach out to me if you have any questions. ADRUCK22 (talk) 03:40, 21 April 2016 (UTC)