Calicheamicin: Difference between revisions
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Calicheamicin is an antibiotic derived from organism [Micromonospora echinospora]. It was isolatied originally from a rock collected in [Waco, Texas] by a hiking [Scripps Institute] chemist. |
Calicheamicin is an antibiotic derived from organism [[Micromonospora echinospora]]. It was isolatied originally from a rock collected in [[Waco, Texas]] by a hiking [[Scripps Institute]] chemist. |
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It is highly toxic |
It is highly toxic but has found pharmacological use as a conjugate in antibody cancer therapeutics (e.g. [[Gemtuzumab]]). |
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=References= |
=References= |
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http://www.scripps.edu/newsandviews/e_20010226/nicolaou3.html |
*http://www.scripps.edu/newsandviews/e_20010226/nicolaou3.html |
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J Antibiot (Tokyo). 1989 Jul;42(7):1070-87. |
*J Antibiot (Tokyo). 1989 Jul;42(7):1070-87. |
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Revision as of 22:29, 29 October 2006
Calicheamicin is an antibiotic derived from organism Micromonospora echinospora. It was isolatied originally from a rock collected in Waco, Texas by a hiking Scripps Institute chemist.
It is highly toxic but has found pharmacological use as a conjugate in antibody cancer therapeutics (e.g. Gemtuzumab).
References
- http://www.scripps.edu/newsandviews/e_20010226/nicolaou3.html
- J Antibiot (Tokyo). 1989 Jul;42(7):1070-87.