Staphylopine dehydrogenase: Difference between revisions
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In [[enzymology]],a '''staphylopine synthase''' ({{EC number|1.5.1.52}}) is an [[enzyme]] that [[Catalysis|catalyzes]] NADPH-dependent reductive condensation of [[pyruvate]] to the intermediate (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, which is the last step in the biosynthesis of the metallophore staphylopine<ref>{{Cite journal|last=Ghssein|first=G.|last2=Brutesco|first2=C.|last3=Ouerdane|first3=L.|last4=Fojcik|first4=C.|last5=Izaute|first5=A.|last6=Wang|first6=S.|last7=Hajjar|first7=C.|last8=Lobinski|first8=R.|last9=Lemaire|first9=D.|last10=Richaud|first10=P.|last11=Voulhoux|first11=R.|date=2016-05-26|title=Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus|url=http://dx.doi.org/10.1126/science.aaf1018|journal=Science|volume=352|issue=6289|pages=1105–1109|doi=10.1126/science.aaf1018|issn=0036-8075}}</ref> |
In [[enzymology]], a '''staphylopine synthase''' ({{EC number|1.5.1.52}}) is an [[enzyme]] that [[Catalysis|catalyzes]] NADPH-dependent reductive condensation of [[pyruvate]] to the intermediate (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, which is the last step in the biosynthesis of the metallophore [[staphylopine]].<ref>{{Cite journal|last=Ghssein|first=G.|last2=Brutesco|first2=C.|last3=Ouerdane|first3=L.|last4=Fojcik|first4=C.|last5=Izaute|first5=A.|last6=Wang|first6=S.|last7=Hajjar|first7=C.|last8=Lobinski|first8=R.|last9=Lemaire|first9=D.|last10=Richaud|first10=P.|last11=Voulhoux|first11=R.|date=2016-05-26|title=Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus|url=http://dx.doi.org/10.1126/science.aaf1018|journal=Science|volume=352|issue=6289|pages=1105–1109|doi=10.1126/science.aaf1018|issn=0036-8075}}</ref> The [[chemical reaction]] is: |
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H<small><sub>2</sub></small>O + NADP<small><sup>+</sup></small> + staphylopine = (2''S'')-2-amino-4-{[(1''R'')-1-carboxy-2-(1''H''-imidazol-4-yl)ethyl]amino}butanoate + H<small><sup>+</sup></small> + NADPH + pyruvate<ref>{{Cite web|url=https://www.uniprot.org/uniprot/A0A0H3JT80|title=cntM - Staphylopine synthase - Staphylococcus aureus (strain Mu50 / ATCC 700699) - cntM gene & protein|website=www.uniprot.org|access-date=2019-12-03}}</ref> |
:H<small><sub>2</sub></small>O + NADP<small><sup>+</sup></small> + staphylopine = (2''S'')-2-amino-4-{[(1''R'')-1-carboxy-2-(1''H''-imidazol-4-yl)ethyl]amino}butanoate + H<small><sup>+</sup></small> + NADPH + pyruvate<ref>{{Cite web|url=https://www.uniprot.org/uniprot/A0A0H3JT80|title=cntM - Staphylopine synthase - Staphylococcus aureus (strain Mu50 / ATCC 700699) - cntM gene & protein|website=www.uniprot.org|access-date=2019-12-03}}</ref> |
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Alternative name(s): '''staphylopine dehydrogenase.''' |
Alternative name(s): '''staphylopine dehydrogenase.''' |
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==References== |
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[[Category:Enzymes]] |
[[Category:Enzymes]] |
Revision as of 00:19, 4 December 2019
In enzymology, a staphylopine synthase (EC 1.5.1.52) is an enzyme that catalyzes NADPH-dependent reductive condensation of pyruvate to the intermediate (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, which is the last step in the biosynthesis of the metallophore staphylopine.[1] The chemical reaction is:
- H2O + NADP+ + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H+ + NADPH + pyruvate[2]
Alternative name(s): staphylopine dehydrogenase.
References
- ^ Ghssein, G.; Brutesco, C.; Ouerdane, L.; Fojcik, C.; Izaute, A.; Wang, S.; Hajjar, C.; Lobinski, R.; Lemaire, D.; Richaud, P.; Voulhoux, R. (2016-05-26). "Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus". Science. 352 (6289): 1105–1109. doi:10.1126/science.aaf1018. ISSN 0036-8075.
- ^ "cntM - Staphylopine synthase - Staphylococcus aureus (strain Mu50 / ATCC 700699) - cntM gene & protein". www.uniprot.org. Retrieved 2019-12-03.