Talk:Coenzyme Q10

Typical dosage

What are typical dosages used when Coenzyme Q10 is taken as a dietary supplement?

30 mg with each meal seems a popular suggestion, but lower and higher doses are used as well. Elroch 10:40, 2 June 2006 (UTC)

I second that. If you have a medical condition, you may want to take more than 30x2 a day, although I wouldn't do that for long without medical supervision.

As per [1]:

CoQ10 has a good safety profile. Daily doses of 50-100mg are well tolerated. Reported side effects are rare, but tend to be various forms of epigastric distress (heartburn, nausea, stomach ache) which can be prevented by consuming the supplement with a meal.

Intakes of 100-200 mg per day have been studied with no apparent adverse side effects, but muscle damage has been noted in at least one study of 120 mg per day over 20 days (perhaps due to a pro-oxidant effect and free radical damage in the muscle).

As per [2]:

Adult levels of supplementation are usually 30–90 mg per day, although people with specific health conditions may supplement with higher levels (with the involvement of a physician). Most of the research on heart conditions has used 90–150 mg of CoQ10 per day. People with cancer who consider taking much higher amounts should discuss this issue with a doctor before supplementing.

Also see [3] for info from NIH. --Amit 01:38, 22 July 2006 (UTC)

Anti-hypertensive

Coenzyme Q10 has been described as an anti-hypertensive in several good-seeming studies (see a review) but this aspect of its use as a supplement is not listed in the article. As I don't feel authoritative on the topic I simply point this possible omission out for potential rectification by an expert. -- cmh 23:09, 1 June 2006 (UTC)

This does seem well-established (the NIH web page on CoQ10, classifies this as being the application of CoQ10 for which there is the best supporting evidence. The code B they give this application is defined as "Good scientific evidence for this use". Elroch 10:40, 2 June 2006 (UTC)

I have some doubts about the analysis on the before mentioned page since it is not possible to understand on what basis the classification is given. I have looked up some of the references and they weren't convincing at all. To the contrary both the AAFP as an revieuw done in the annals of pharmocotherapy doubt the use of Q10 as a treatment option.

Links: AAFP [4] Ann Pharmocoth [5]

Dietary Sources

As a "Vitamin", the Co Q should have Dietary Sources (natural, herbs, ...), along with the dried powder.--Connection 00:16, 3 July 2006 (UTC)

References and citation

This page looks great. Please make footnotes to the articles for each thing I've put a 'citation needed' flag next to, just to steamline the references. Thanks

Added some. Not exhaustive at all. Used the cite template. Hope that helps! :-) Jon 01:12, 1 December 2006 (UTC)

Why does production decrease with age?

Why does the body's production of CoQ decrease with age? What produces CoQ? Is it produced by a gland? What can be done to prevent the decrease of production in the first place? Beyond the classroom 03:27, 16 December 2006 (UTC)