Dextrorphan: Difference between revisions
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==See also== |
==See also== |
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*[[Dextromethorphan]] |
*[[Dextromethorphan]] |
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*[[Racemethorphan]] |
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*[[Morphinans]] |
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[[pl:Dekstrorfan]] |
[[pl:Dekstrorfan]] |
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[[category:morphinans]] |
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Revision as of 10:23, 1 January 2007
Dextrorphan (DX) is a pharmacologically active metabolite of dextromethorphan (DM, DXM).
Chemistry
It is the result of O-demethylation of the prodrug by several enzymatic systems, although it is chiefly a product of the Cytochrome P450 IID6 (CYP4502D6) pathway.
Pharmacology
Being structurally similar to dextromethorphan, and it has affinity for the same receptors in the central nervous system but with a slight difference in selectivity.
Dextromethorphan is a weak non-competitive NMDA receptor antagonist but dextrorphan is a more potent antagonist[1]. DX is a strong anti-tussive[citation needed], but is slightly less effective than DM, and has no metabolites with significant therapeutic activity in such capacity and therefore is not a drug available on the market.
See also
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