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Jean Baum

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Jean Baum
Alma materBarnard College (AB), University of California, Berkeley (PhD)
Scientific career
Doctoral advisorAlexander Pines
Websitehttps://rutchem.rutgers.edu/the-baum-group-home

Jean Baum is an American chemist. She is the Distinguished Professor of Chemistry and Chemical Biology at Rutgers University, where she is also Vice Dean for Research and Graduate Education in the School of Arts and Sciences, and also Vice Chair of the Department of Chemistry and Chemical Biology.[1] Her research investigates protein–protein interaction and protein aggregation using nuclear magnetic resonance spectroscopy (NMR) and other biochemical and biophysical techniques.[2] She serves as Treasurer for the Protein Society.[1]

Education

Baum obtained her bachelor degree magna cum laude at Barnard College in 1980. She completed her PhD in physical chemistry with Alexander Pines at University of California, Berkeley from 1981-1986, working on solid-state NMR.[3][4]

Research and career

After completing her PhD, Baum changed her research focus towards biological applications of NMR, especially in solution-state. She worked with Chris Dobson at University of Oxford from 1986-1988,[5] while holding a Fulford junior research fellowship at Somerville College.[4] During this time, she used NMR to investigate partly folded and misfolded proteins.[6] She joined Rutgers University in 1988 as a Henry Rutgers Research Fellow, and was promoted to Distinguished Professor in 2010.[3][4]

Baum uses both solution- and solid-state NMR in her research. Her research investigates the structure and dynamics of proteins, including alpha-synuclein,[7][8] which can form amyloid fibrils, and collagen.[2][9][10][11] The molecular interactions involved in the assembly of the functional and pathological forms of these proteins can be elucidated by NMR investigations.[12] Since May 2020, her research has included studying the SARS-CoV-2 spike protein using a combined experimental and computational approach.[13]

Honors and Awards

  • Fulford Junior Research Fellow, University of Oxford, England, 1986-1988
  • Henry Rutgers Research Fellow, 1988-1990
  • Merck Faculty Development Award; 1988-1990
  • Searle Scholar, 1990-1993
  • Johnson and Johnson Discovery Research Fund, 1993
  • Camille & Henry Dreyfus Teacher-Scholar Award, 1993-1998
  • Margaret O. Dayhoff Biophysical Society Award, 1994
  • Rutgers University Board of Trustees Scholarly Excellence Fellowship, 1994
  • Alfred P. Sloan Fellow, 1994-1996
  • Visiting Fellow, Clare Hall, University of Cambridge, England, 2009

References

  1. ^ a b "Jean Baum". Rutgers School of Arts and Sciences. Retrieved 2021-05-04.{{cite web}}: CS1 maint: url-status (link)
  2. ^ a b "The Baum Group - Home". rutchem.rutgers.edu. Retrieved 2021-05-04.{{cite web}}: CS1 maint: url-status (link)
  3. ^ a b "The Protein Society : Jean S. Baum". www.proteinsociety.org. Retrieved 2021-05-04.
  4. ^ a b c "Baum, Jean". rutchem.rutgers.edu. Retrieved 2021-05-04.
  5. ^ Baum, Jean; Chiti, Fabrizio; De Simone, Alfonso; Knowles, Tuomas P. J.; Kumita, Janet R.; Radford, Sheena E.; Robinson, Carol V.; Salvatella, Xavier; Valelli, Karen; Vendruscolo, Michele; Pastore, Annalisa (2019-12-12). "Homage to Chris Dobson". Frontiers in Molecular Biosciences. 6. doi:10.3389/fmolb.2019.00137. ISSN 2296-889X. PMC 6921691. PMID 31921887.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Baum, Jean; Dobson, Christopher M.; Evans, Philip A.; Hanley, Claire (1989-01-10). "Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig .alpha.-lactalbumin". Biochemistry. 28 (1): 7–13. doi:10.1021/bi00427a002. ISSN 0006-2960.
  7. ^ "Structural Reorganization of α-Synuclein at Low pH Observed by NMR and REMD Simulations". Journal of Molecular Biology. 391 (4): 784–796. 2009-08-28. doi:10.1016/j.jmb.2009.06.063. ISSN 0022-2836.
  8. ^ Kang, Lijuan; Moriarty, Gina M.; Woods, Lucy A.; Ashcroft, Alison E.; Radford, Sheena E.; Baum, Jean (2012-07-XX). "N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer: N-Terminal Acetylation of α-Synuclein". Protein Science. 21 (7): 911–917. doi:10.1002/pro.2088. PMC 3403430. PMID 22573613. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)
  9. ^ Long, Cynthia Gwynne; Braswell, Emory; Zhu, Dan; Apigo, Josefa; Baum, Jean; Brodsky, Barbara (1993-01-26). "Characterization of collagen-like peptides containing interruptions in the repeating Gly-X-Y sequence". Biochemistry. 32 (43): 11688–11695. doi:10.1021/bi00094a027. ISSN 0006-2960.
  10. ^ Long, Cynthia Gwynne; Braswell, Emory; Zhu, Dan; Apigo, Josefa; Baum, Jean; Brodsky, Barbara (1993-01-26). "Characterization of collagen-like peptides containing interruptions in the repeating Gly-X-Y sequence". Biochemistry. 32 (43): 11688–11695. doi:10.1021/bi00094a027. ISSN 0006-2960.
  11. ^ "Folding of peptide models of collagen and misfolding in disease". Current Opinion in Structural Biology. 9 (1): 122–128. 1999-02-01. doi:10.1016/S0959-440X(99)80016-5. ISSN 0959-440X.
  12. ^ "Faculty Research - Baum, Jean". rutchem.rutgers.edu. Retrieved 2021-05-04.{{cite web}}: CS1 maint: url-status (link)
  13. ^ "COVID-19: SARS-CoV-2 Spike Protein". chem.rutgers.edu. Retrieved 2021-05-04.

Category:Living people Category:American chemists Category:Rutgers University faculty Category:21st-century American chemists Category:21st-century American scientists Category:American biochemists

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