Hovlinc
| Hovlinc | |
|---|---|
 Consensus secondary structure and sequence conservation of Hovlinc ribozyme (hominin vlincRNA-located) | |
| Identifiers | |
| Symbol | Hovlinc |
| Rfam | RF04188 |
| Other data | |
| RNA type | Gene; Ribozyme |
| Domain(s) | Hominidae |
| GO | GO:0003824 |
| SO | SO:0000374 |
| PDB structures | PDBe |
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The hovlinc ribozyme is a self-cleaving ribozyme found in a very long noncoding RNA (vlincRNA) in hominins like humans, chimpanzees, and gorillas[1]. Hovlinc stands for "hominin vlincRNA-located" ribozyme based on its host gene and taxonomic range. Self-cleavage activity of hovlinc has been proven in humans, chimpanzees and bonobos (genus Pan), but absent in gorillas[1]. The discovery of this ribozyme is significant because only a small number of self-cleaving ribozymes has been reported in humans including Mammalian CPEB3 ribozyme, Hammerhead ribozyme (HH9 and HH10) and a B2 SINE ribozyme[2].
References
- ^ a b Chen, Yue; Qi, Fei; Gao, Fan; Cao, Huifen; Xu, Dongyang; Salehi-Ashtiani, Kourosh; Kapranov, Philipp (2021). "Hovlinc is a recently evolved class of ribozyme found in human lncRNA". Nature Chemical Biology. 17 (5): 601–607. doi:10.1038/s41589-021-00763-0. ISSN 1552-4469. PMID 33753927.
- ^ Hernandez, Alfredo J.; Zovoilis, Athanasios; Cifuentes-Rojas, Catherine; Han, Lu; Bujisic, Bojan; Lee, Jeannie T. (2020-01-07). "B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2". Proceedings of the National Academy of Sciences. 117 (1): 415–425. doi:10.1073/pnas.1917190117. PMC 6955291. PMID 31871160.