Fu-Kuen Lin
Fu-Kuen Lin (Chinese: 林福坤; born 1941 in Keelung, Taiwan) is a mycological physiologist, nephrologist and hematologist.
Lin received his B.S. from National Taiwan University in 1964 and M.S. in plant pathology in 1967. That year, he moved to the United States to study fungi physiology under Professor David Gottlieb, at the University of Illinois at Urbana-Champaign. Lin was awarded a doctorate in plant pathology in 1971. He held postdoctoral and visiting scientist positions at several institutions between 1971 and 1981. He was an associate research fellow at the Institute of Botany, Academia Sinica in Taiwan from 1975 to 1977 and an adjunct associate professor at the National Taiwan University from 1976 to 1977.
Fu-Kuen Lin joined Amgen, a biotech company as a research scientist in August 1981. He was involved with Amgen's recombinant human erythropoietin (EPO) project from the start, and was soon leading the team, which was developing EPO based on a small sample of the hormone that had been isolated by a team led by Eugene Goldwasser at the University of Chicago.[1] In 1983 his team successfully established the gene coding for it[2] and recombinant human erythropoietin was approved by the US FDA in June 1989[3] with the generic name epoetin alpha, tradename Epogen.[4][5]
Lin was also engaged in developing novel pharmaceutics and studying their molecular mechanisms. His primary research interests were in the fields of hematology, hypertension, immune regulation and fungi physiology. He retired from Amgen as the Director of the Department of Biomedical Sciences in 1998. Lin is the inventor of seven US patents covering “DNA Sequences Encoding Erythropoietin” and “Production of Erythropoietin”. Among other honors, he is a recipient of the “1989 Technology Corridor 100” Award; the 1990 “Quality of Life” Award; the “1995 Discoverers Award” (by Pharmaceutical Research and Manufacturers of America);[6] and the Committee of 100, Pioneer Recognition Award in May 2002.
References
- ^ Pollack, Andrew. "Eugene Goldwasser, Biochemist Behind an Anemia Drug, Dies at 88", The New York Times, 20 December 2010. Accessed 27 December 2010.
- ^ Bates, James (2 June 1989). "Biotech Detective Scores Coup: Amgen scientist spent years searching for the key to producing EPO". The Los Angeles Times.
- ^ Koerth-Baker, Maggie (21 July 2010). "The $2 billion error". BoingBoing. Archived from the original on 24 July 2010.
- ^ "Amgen—A biotechnology success story: From drug development to the mass market". MaRS. 5 November 2012. Archived from the original on 24 October 2014.
- ^ Herman, Robin (16 June 1992). "One Patented Gene's Astounding Success Story". The Washington Post.
- ^ "1995 Discoverers Award: Amgen Scientist". thepharmaletter. 16 October 1995. Archived from the original on 15 January 2019.
Selected works
- Lin F. (1984), DNA sequences encoding erythropoietin., US-Patent 4,703,008 (30 November 1984).
- Lin F. et al. (1985) "Cloning and expression of the human erythropoietin gene" Proceedings of the National Academy of Sciences 82: 7580-7584.
References
- Fu-Kuen Lin’s Biography Monte Jade Science and Technology Association;
- Amgen 2004 Annual Report - Defining Moments - The Discovery of Epogen - The Story;
- Fritsch v. Lin Board of Patent Appeals and Interferences, Patent and Trademark Office (P.T.O.) 3 December 1991;
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