Exerkine
An exerkine is a signaling molecule secreted in response to exercise that helps mediate systemic adaptations to exercise.[1][2] Their study is the focus of the field of exercise endocrinology. The first exerkine to be identified was IL-6, which is secreted from contracting muscles.[3]
- ^ Safdar, A; Saleem, A; Tarnopolsky, MA (September 2016). "The potential of endurance exercise-derived exosomes to treat metabolic diseases". Nature reviews. Endocrinology. 12 (9): 504–17. doi:10.1038/nrendo.2016.76. PMID 27230949.
- ^ Chow, LS; Gerszten, RE; Taylor, JM; Pedersen, BK; van Praag, H; Trappe, S; Febbraio, MA; Galis, ZS; Gao, Y; Haus, JM; Lanza, IR; Lavie, CJ; Lee, CH; Lucia, A; Moro, C; Pandey, A; Robbins, JM; Stanford, KI; Thackray, AE; Villeda, S; Watt, MJ; Xia, A; Zierath, JR; Goodpaster, BH; Snyder, MP (May 2022). "Exerkines in health, resilience and disease". Nature reviews. Endocrinology. 18 (5): 273–289. doi:10.1038/s41574-022-00641-2. PMID 35304603.
- ^ Steensberg, A; van Hall, G; Osada, T; Sacchetti, M; Saltin, B; Klarlund Pedersen, B (15 November 2000). "Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6". The Journal of physiology. 529 Pt 1 (Pt 1): 237–42. doi:10.1111/j.1469-7793.2000.00237.x. PMID 11080265.