Jump to content

Chinfei Chen

Add links
From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Minuette Macon (talk | contribs) at 17:55, 30 April 2024 (Edited for brevity and facts). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Introduction

Chinfei Chen is an American neuroscientist and member of the American Academy of Arts and Sciences studying synaptic plasticity.[1][2][3][4][5][6] She currently serves as a professor of neurology at Harvard Medical School[7] and the associate director of the Harvard Program in Neuroscience.[8]

Early Life

Chinfei Chen, born to Taiwanese immigrants, spent her early years in Wilmington, Delaware.[9] Her father had previously moved to the United States to pursue a graduate degree in architecture.[9] As Chen grew older, she and her family relocated to New York City, where she received her education through the city's public school system.[9]

Education and Career

While in New York, Chen went to Stuyvesant High School.[9] She attended the University of Pennsylvania to pursue a Bachelor of Applied Science in engineering.[9] During her undergraduate years, she joined Britton Chance's laboratory, where she studied flavoproteins in the brain.[9] Chen later obtained her M.D. and Ph.D. from Harvard Medical School.[9] While in medical school, she worked with Edward Kravitz to research neurotransmitter signaling pathways in lobsters.[9] She also worked with Peter Hess on calcium channel biophysics for her Ph.D. Chen then completed her residency in adult neurology at Massachusetts General Hospital.[9][10], followed by postdoctoral training with Wade Regehr at Harvard Medical School.[9][10] She is currently a professor of neurology at Harvard Medical School[11], and the associate director of the Harvard Graduate Program in Neuroscience[11]. Furthermore, Chen also works as a Research Associate in Neurology at the Boston Children's Hospital[8].

Research

Chen's first experience in a research lab was spent observing fluorescent activity in rat brains as a measurement for metabolic activity.[9] She did her residency at Mass General and decided to study the thalamus during her postdoctoral training.[9] Chen's research focuses on mechanisms of synaptic and circuit plasticity in the mammalian central nervous system, for which she was recognized by the AAAS.[12][1] Chen's research includes the study of boutons that send information to the thalamus.[12] Chen's research projects have also focused on Autism, specifically in relation to the corticothalamic circuit interactions in Autism. [13]

Personal Life

In her free time outside of the lab, Chen gardens and creates floral arrangements and is a fan of Boston Red Sox.[9] After being gifted hockey gear from her husband, Chen learned how to play ice hockey and enjoys the sport for exercise.[9]

Selected Publications[5]

  • Taub, D. G., Jiang, Q., Pietrafesa, F., Su, J., Carroll, A., Greene, C., Blanchard, M. R., Jain, A., El-Rifai, M., Callen, A., Yager, K., Chung, C., He, Z., Chen, C., & Woolf, C. J. (2024, February 12). The secondary somatosensory cortex gates mechanical and heat sensitivity. Nature Communications. https://doi.org/10.1038/s41467-024-45729-7
  • Tzeng, C. P., Whitwam, T., Boxer, L. D., Li, E., Silberfeld, A., Trowbridge, S., Mei, K., Lin, C., Shamah, R., Griffith, E. C., Renthal, W., Chen, C., & Greenberg, M. E. (2023, October 23). Activity-induced MeCP2 phosphorylation regulates retinogeniculate synapse refinement. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2310344120
  • Liang, L., & Chen, C. (2020, September 15). Organization, Function, and Development of the Mouse Retinogeniculate Synapse. Annual Review of Vision Science. https://doi.org/10.1146/annurev-vision-121219-081753
  • Chen, D., Liu, Y., Shu, G., Chen, C., Sullivan, D. A., Kam, W. R., Hann, S., Fowler, M. E., & Warman, M. L. (2020, May 21). Ocular Manifestations of Chordin-like 1 Knockout Mice. Cornea. https://doi.org/10.1097/ico.0000000000002371
  • Liu, Y., Latrémolière, A., Li, X., Zhang, Z., Chen, M., Wang, X., Fang, C., Zhu, J., Alexandre, C., Gao, Z., Chen, B., Ding, X., Zhou, J., Zhang, Y., Chen, C., Wang, K. H., Woolf, C. J., & He, Z. (2018, September 1). Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. https://doi.org/10.1038/s41586-018-0515-2
  • Hong, Y. K., Burr, E., Sanes, J. R., & Chen, C. (2018, August 7). Heterogeneity of retinogeniculate axon arbors. European Journal of Neuroscience/EJN. European Journal of Neuroscience. https://doi.org/10.1111/ejn.13986
  • Litvina, E. Y., & Chen, C. (2017, January 1). An evolving view of retinogeniculate transmission. Visual Neuroscience. https://doi.org/10.1017/s0952523817000104
  • Thompson, A., & Chen, C. (2017, January 1). The importance of constructive feedback: Implications of top-down regulation in the development of neural circuits. Neurogenesis. https://doi.org/10.1080/23262133.2017.1287553
  • Hauser, J. L., Liu, X., Litvina, E. Y., & Chen, C. (2014, October 1). Prolonged synaptic currents increase relay neuron firing at the developing retinogeniculate synapse. Journal of Neurophysiology. https://doi.org/10.1152/jn.00451.2014
  • Lin, D. J., Kang, E., & Chen, C. (2014, August 15). Changes in input strength and number are driven by distinct mechanisms at the retinogeniculate synapse. Journal of Neurophysiology. https://doi.org/10.1152/jn.00175.2014
  • Chung, W., Clarke, L., Wang, G., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., Smith, S. J., & Barres, B. A. (2013, November 24). Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature. https://doi.org/10.1038/nature12776
  • Kang, E., Durand, S., LeBlanc, J. J., Hensch, T. K., Chen, C., & Fagiolini, M. (2013, November 6). Visual Acuity Development and Plasticity in the Absence of Sensory Experience. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1500-13.2013
  • Hauser, J. L., Edson, E. B., Hooks, B. M., & Chen, C. (2013, January 1). Metabotropic glutamate receptors and glutamate transporters shape transmission at the developing retinogeniculate synapse. Journal of Neurophysiology. https://doi.org/10.1152/jn.00897.2012
  • Roy, K., Murtie, J., El‐Khodor, B. F., Edgar, N., Sardi, S. P., Hooks, B. M., Benoît-Marand, M., Chen, C., Moore, H., O’Donnell, P., Brunner, D., & Corfas, G. (2007, May 8). Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0702157104
  • Chen, D., Liu, Y., Shu, G., Chen, C., Sullivan, D. A., Kam, W. R., Hann, S., Fowler, M. E., & Warman, M. L. (2020, May 21). Ocular Manifestations of Chordin-like 1 Knockout Mice. Cornea. https://doi.org/10.1097/ico.0000000000002371

References

  1. ^ a b "2024 New Member List | American Academy of Arts and Sciences". www.amacad.org. Retrieved 2024-04-29.
  2. ^ "Newsroom | Two Boston Children's Hospital Researchers Elected to The American Academy of Arts & Sciences | Boston Children's Hospital". www.childrenshospital.org. Retrieved 2024-04-29.
  3. ^ "2024 New Member List | American Academy of Arts and Sciences". www.amacad.org. Retrieved 2024-04-29.
  4. ^ "News & Research". hms.harvard.edu. Retrieved 2024-04-29.
  5. ^ a b "Chen, Chinfei[Full Author Name] - Search Results - PubMed". PubMed. Retrieved 2024-04-26.
  6. ^ "Balancing the Brain | Nursing Today. Nursing Journals : American Society of Registered Nurses". www.asrn.org. Retrieved 2024-04-29.
  7. ^ "Rett protein alters visual circuits in mice". Spectrum | Autism Research News. 2011-05-23. Retrieved 2024-04-29.
  8. ^ a b "Chinfei Chen". Harvard Brain Science Initiative. Retrieved 2024-04-26.
  9. ^ a b c d e f g h i j k l m n "Episode 24: Chinfei Chen, MD PhD". Conjugate: Illustration and Science Blog. Retrieved 2024-04-26.
  10. ^ a b "Chinfei Chen". ERM 2019. Retrieved 2024-04-29.
  11. ^ a b "Chinfei Chen". dms.hms.harvard.edu. Retrieved 2024-04-26.
  12. ^ a b "Scientists Visualize the Connections Between Eye and Brain". www.bidmc.org. Retrieved 2024-04-29.
  13. ^ "2024 Thalamocortical Interactions Conference GRC". www.grc.org. Retrieved 2024-04-29.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Chinfei_Chen&oldid=1221568622"