Rhodosporidiobolus fluvialis
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Rhodosporidium fluvialis
Rhodosporidium fluvialis is a species of fungus in the family Sporidiobolaceae. It is a human fungal pathogen that exhibits resistance to antifungal compounds like fluconazole and caspofungin.
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| Species: | R. fluvialis
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| Rhodosporidium fluviale (Author Name, Year)
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Antifungal Resistance
Rhodosporidium fluvialis was isolated from two independent patients. It can proliferate well at 37 °C, a temperature similar to the human body's internal temperature. When it is incubated at 37 °C, reactive oxygen species accumulate and damage its DNA, which causes mutations that lead to the development of resistance to amphotericin-B.[1]
R. fluvialis colonies can be pigmented due to the accumulation of carotenoids in the cells. Carotenoid production has been associated with its resistance to caspofungin.[1]
References
- ^ a b Huang, Jingjing; Hu, Pengjie; Ye, Leixin; Shen, Zhenghao; Chen, Xinfei; Liu, Fang; Xie, Yuyan; Yu, Jinhan; Fan, Xin; Xiao, Meng; Tsui, Clement K. M.; Wang, Weiping; Li, Yingxing; Zhang, Ge; Wong, Koon Ho (2024-07). "Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature". Nature Microbiology. 9 (7): 1686–1699. doi:10.1038/s41564-024-01720-y. ISSN 2058-5276.
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