Peter Tishler

Wikipedia Project draft 2 -DRAFT-

Peter Verveer Tishler is the consummate researcher, educator, and clinician. A long-time researcher in human genetics and orphan diseases, Peter Tishler has devoted his medical career to the study of genetic diseases, including polycystic kidney disease, chronic obstructive pulmonary disease (link), Fabry disease (link), and the porphyrias (link). He has educated generations of academic physicians and staunchly cared for the disenfranchised in city hospitals Boston Medical Center, academic centers Brigham and Women's Hospital Beth Israel Deaconess Hospital, and Veteran’s Administration Hospitals (link). He perpetuates the life stories of his many mentors through his teaching, writing, and contributions to the history of medicine. When he is not devoting time and attention to all things medical, he is a loving husband, father and grandfather who enjoys nature (link to Royalston, MA), music, cultivating orchids (link), gardening, birding (link), running (link) and learning about fine wines (link).

Born July 18, 1937 to Elizabeth Verveer and Max Tishler (link), Peter spent his childhood in New Jersey. His home was steeped in scientific research as his father was a senior research chemist and later president of Merck (link). He attended public school through high school. As a teenager, he traveled by himself from Westfield into Manhattan to take tuba lessons from a New York Philharmonic teacher. He spent summers in Roscoe, New York (link) with his brother Carl, born when Peter was 10. Since childhood, he has been a pet lover, with innumerable special dogs, cats and horses.

Tishler attended Harvard College (link) where he majored in Biochemical Sciences. It was there that he began his lifelong dedication to genetics, influenced by R. Paul Levine. He wrote his senior thesis on carboxypeptidase, in the lab of Dr. C.J. Fu at the Jimmy Fund, graduating cum laude in 1959. During a summer at the Jimmy Fund, he met Sigrid (Sigi) Ann Lemlein, a Radcliffe College undergraduate (link) doing research with Dr. Edward Modest. They became engaged at the end of Peter’s senior year in college and were married in 1960.

Peter and Sigi attended Yale Medical School. While at Yale, Dr. Tishler began his long association with the Thorndike Memorial Laboratory at Boston City Hospital. Dr. William B. Castle, discoverer of intrinsic factor (link), introduced him to Dr. Sidney H. Ingbar (link) with whom he began to work on the metabolic actions of thyroid hormone. Another important mentor, Dr. Maxwell Finland contributed to Peter’s scientific and clinical work in many ways. One time, Dr. Finland’s prodigious infectious disease knowledge even helped cure a colony of sick frogs! Tishler’s nascent interest in genetics arose from his laboratory research when he began to study thyroid function in patients with phenylketonuria (link), the consequences of which are now entirely preventable in the developed world.

Peter left New Haven for the prestigious Harvard Medical Service at Boston City Hospital in 1963. The service was known not only for taking care of indigent, challenging patients, but for the dedication and caring of its professors and staff. Tishler grew professionally and clinically from his contact with special mentors, among them Charlie Davidson, Ronald Arky, Norbert Frankel and William B. Castle. He developed close friendships with his contemporaries that continue to enrich his life, personally and professionally, over 40 years later.

Dr. Finland and Dr. Ingbar encouraged him to pursue his growing interest in medical genetics. During the Vietnam War (link), Tishler went to Bethesda, Md. as a Public Health Service officer at the National Institutes of Health (link). There he worked with Chris Anfinsen, Charles Epstein and Alan Schechter on the biochemistry of embryogenesis. During this time, the assassination of Dr. Martin Luther King, Jr. was followed by protests, fires and looting in Washington, D.C. Tishler, an active participant in the Civil Right’s Movement, went immediately to the city jail to help protesters who may have been injured following their beliefs (link).

Peter and Sigi expanded their family in the late 1960’s to include their son Jordan (born in Washington D.C in 1966) and daughter Alison (born in Boston in 1969). They settled in Brookline (link), MA where Tishler returned to form the first genetics division of the Harvard Medical Unit at Boston City Hospital. They also bought land in Royalston, Massachusetts, where they designed and built a retreat, The Farm.

During the next 9 years, Peter continued his basic laboratory work, but also began to think about genetics and medicine in the terms of population and epidemiology. Drs. Edward H. Kass and Frank Speizer guided his thinking about these issues. He was named the Francis Weld Peabody (link) Fellow, developed a consultative genetics practice and acquired a group of patients, for whom he still provides care. Tishler was also involved in familial studies of hypertension at one of the first community health centers in the nation, East Boston Neighborhood Health Center. When the Harvard Medical Unit at Boston City Hospital closed its doors in 1977, he moved with the Channing Lab to its new home on Harvard Medical School’s Longwood campus and began his long association with what is now known as Brigham and Women’s Hospital (link).

In 1980, Peter moved to the VA Hospitals in West Roxbury, MA and in Brockton, MA. As Associate Chief of Medicine at the VA in Brockton and Associate Chief of Staff for Education, he was responsible for the oversight of multiple residency training programs associated with the VA Medical Center through Harvard teaching hospitals, particularly the Beth Israel Hospital (link) and Brigham and Women’s Hospital (link). Known as a staunch advocate for physicians in training, a generous teacher and gifted clinician, residents remember that if Dr. Tishler was teaching, you’d better have spun the urine and looked at the gram stain – before rounds.

Tishler was known to be never too busy to leave his office or lab to teach a procedure, answer a question, or consult on a patient. He was a devoted advocated for disabled veterans (link) who often had no family or friends to speak for them. While he conducted medical research, he participated as a subject in the landmark Physician’s Health Study that has helped us understand so much about preventive health care for men in the late twentieth and early twenty first centuries.

As Tishler’s children grew, his family expanded to include daughter-in-law Lori Wiviott Tishler and son-in-law Steven Cantrell. Between 1992 and 2003, Sigi and Peter welcomed 4 wonderful grandchildren, who call him as Pop, into their lives. The ever-present index cards from his pocket took on new life as an important art medium for the children.

After leaving the VA in 2002, Tishler has continued his work at the Channing Laboratory (link) and BWH. Following the explosion of knowledge in the field of genetics and epidemiology over the last decades, his interests have expanded to include consideration of the genetics of complex diseases such as obstructive sleep apnea (link) and bicuspid aortic valve disease (link); he continues to care for patients with orphan diseases and to teach residents and students. A former member of the board of the Boston Medical Library, he continues to participate actively in the Countway Library’s Center for the History of Medicine. His non-medical interests in nature have led to recent travels to the Galapagos Islands (link) and two terms as President of the Massachusetts Orchid Society.

References:

Finland, Maxwell and Castle, William B., Eds. The Harvard Medical Unit at Boston City Hospital, Volume II. University of Virginia Press (for the Francis A. Countway Library of Medicine), 1983.

Selected Publications:

Linkage of serum leptin levels in families with sleep apnea. Int J Obes (Lond). 2005 Mar;29(3):260-7

Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med. 2004 Jun 15; 169(12):1314-21. Epub 2004 Apr 7.

Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing. JAMA. 2003 May 7;289(17):2230-7

The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria. Life Sci. 1999;65(2):207-1

Fetal alcohol effects in alcoholic veteran patients. Alcohol Clin Exp Res. 1998 Nov;22(8):1825-31

A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992 Aug 19;268(7):877-81

"The care of the patient": a living testimony to Francis Weld Peabody. Pharos Alpha Omega Alpha Honor Med Soc. 1992 Summer;55(3):32-6
Thoughts as I watched the Peabody Building fall, March 31, 1990. N Engl J Med. 1990 Oct 11;323(15):1074

Healthy female carriers of a gene for the Alport syndrome: importance for genetic counseling. Clin Genet. 1979 Oct;16(4):291-4

A family with coexistent von Recklinghausen's neurofibromatosis and von Hippel-Lindau's disease. Diseases possibly derived from a common gene. Neurology. 1975 Sep;25(9):840-4.

Phenylketonuria: therapeutic problems. Br Med J. 1969 Feb 22;1(5642):510

Effect of thyroxine administered in vitro and in vivo on the succinoxidase and malic dehydrogenase reactions of frog myocardium. Endocrinology. 1963 May;72:673-6

External Links:

http://www.porphyriafoundation.com/about_apf/advisory/tishler.html
http://genetics.bwh.harvard.edu/genetics/labs/Tishler/index.html
http://countway.med.harvard.edu/rarebooks/exhibits/finland/mfindex.htm