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Diagnostic test

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A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example:

  • to diagnose diseases
  • to measure the progress or recovery from disease
  • to confirm that a person is free from disease

A drug test can be a specific medical test to acertain the presence of a certain drug in the body (for example, in drug addicts).

Overview

Some medical tests are parts of a simple physical examination which require only simple tools in the hands of a skilled practitioner, and can be performed in an office environment. Some other tests require elaborate equipment used by medical technologists or the use of a sterile operating theatre environment.

Some tests require samples of tissue or body fluids to be sent off to a pathology lab for further analysis. Some simple chemical tests, such as urine pH, can be measured directly in the doctor's office.

Most medical tests are conducted on the living; however, some of these tests can also be carried out on a dead person as part of an autopsy.

The validity of diagnostic test results produced in each laboratory is entirely dependent on the measures employed before, during, and after each assay. Consistency in the production of good results requires an overall program that includes quality assurance, quality control, and quality assessment.

Medical tests can be classified into three categories:

Test Characteristics

Accuracy Accuracy of a laboratory tests is its correspondence with the true value. Accuracy is maximized by calibrating laboratory equipment with reference material and by participation in external quality control programs.

Precision The precision is a measure of tests reproducibility when repeated on the same sample. An imprecise test is one that yield widely varying results on repeated measurement. The precision is monitored in laboratory by using control material.


Properties

The result of a test may be positive or negative: this has nothing to do with a bad prognosis, but rather means that the test worked or not, and a certain parameter that was evaluated was present or not. For example, a negative screening test for breast cancer means that no sign of breast cancer could be found (which is in fact very positive for the patient).

Bayesian probability and performance metrics

Other characteristics of tests include:

Types of medical tests

Consulting room tests

More invasive examinations requiring sterile procedures

Requiring laboratory analysis

Requiring microscopy

Requiring elaborate medical equipment

Psychological effects of diagnostic tests

Medical tests can have value when results are abnormal by explaining to a patient the cause of their symptoms[1]. In addition, normal test results can have value by reassuring patients that serious illness is not present and even reduce the rates of subsequent symptoms [2]. Understanding the meaning of a normal test in advance of learning the test results may also reduce the rates of subsequent symptoms [3].

Lack of adequate education about the meaning of test results (especially relevant to tests that may have incidental and unimportant findings) may cause an increase in symptoms [4]. In addition, the possible benefits must be weighed against the costs of unnecessary tests and resulting unnecessary follow-up and possibly even unnecessary treatment of incidental findings [5].

See also

References

  1. ^ Ward B, Wu W, Richter J, Hackshaw B, Castell D (1987). "Long-term follow-up of symptomatic status of patients with noncardiac chest pain: is diagnosis of esophageal etiology helpful?". Am J Gastroenterol. 82 (3): 215–8. PMID 3826028.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Sox H, Margulies I, Sox C (1981). "Psychologically mediated effects of diagnostic tests". Ann Intern Med. 95 (6): 680–5. PMID 7305144.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Petrie K, Müller J, Schirmbeck F, Donkin L, Broadbent E, Ellis C, Gamble G, Rief W (2007). "Effect of providing information about normal test results on patients' reassurance: randomised controlled trial". BMJ. 334: 352. doi:10.1136/bmj.39093.464190.55. PMID 17259186.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Kendrick D, Fielding K, Bentley E, Kerslake R, Miller P, Pringle M (2001). "Radiography of the lumbar spine in primary care patients with low back pain: randomised controlled trial". BMJ. 322 (7283): 400–5. doi:10.1136/bmj.322.7283.400. PMID 11179160.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Jarvik J, Hollingworth W, Martin B, Emerson S, Gray D, Overman S, Robinson D, Staiger T, Wessbecher F, Sullivan S, Kreuter W, Deyo R (2003). "Rapid magnetic resonance imaging vs radiographs for patients with low back pain: a randomized controlled trial". JAMA. 289 (21): 2810–8. doi:10.1001/jama.289.21.2810. PMID 12783911.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Diagnostic medical tests - Informative, educational and user- friendly web site that offers valuable information about laboratory services, diagnostic and medical tests with comprehensive references and information.
  • Detecting breast cancer earlier - Breast cancer research foundation web site. Information on breast cancer medical researches that demonstrates the potential for discovering earlier methods of detecting breast cancer.
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