Talk:Area postrema

This sentence is in your Anatomy section: “The vagal triangle overlies the dorsal vagal nucleus and it situated on the caudal end…” and I think that instead of “it” you meant “is.” Otherwise, this section is very informational and cohesive.

You end your article by saying that “research on this circumventricular organ has continued to thrive,” but you do not talk about any ongoing studies. Are there any? What is the aim of continuing to study this? It would be good to have at least one article to back that statement to talk about research today and possible directions it may take. Development of the area postrema: An immunohistochemical study in the macaque, Brain Research, Volume 1280, 14 July 2009, Pages 23-32. This is a paper that talks about a monkey model used to study the area postrema. Maybe talking about their research would be a valuable addition that could back your statement that this research is continuing to thrive. Also in this article, there is a large amount of mechanistic information. Most of it is thick and may bog down your article if you take too much from it, but maybe an example would be useful? Aaron.fishman (talk) —Preceding undated comment added 23:26, 22 November 2009 (UTC).

I found an article that could definitely help elaborate and expand on the point you make in the 2nd paragraph of the Pathology section. You state, "Stimulation of the dopamine receptors in the area postrema activates the vomiting centers of the brain; this is why nausea is one of the most common side effects of antiparkinsonian drugs." The article by Yoshikawa and Yoshida, titled Effect of 6-Hydroxydopamine Treatment in the Area Postrema on Morphine-Induced Emesis in Ferrets, describes how the treatment of ferrets with 6-hydroxydopamine into the area postrema reduced the nausea associated with dopamine-induced vomiting by lowering levels of dopamine and homovanilic acid. Thus, this article could be used as a point to explain how certain drugs are able to reduce nausea and vomiting, while also further defining the effect of dopamine on nausea and vomiting. The article is found at this url: http://www.jstage.jst.go.jp/article/jjp/89/4/89_422/_article/-char/en. Hope this helps. Giantsjs2000 (talk) 00:16, 24 November 2009 (UTC)

In the history and current research section, it is acknowledged that Borison and Wang proposed the role of the area postrema in emesis, which is said to have been later confirmed by many laboratories, but it goes on to say that the model that they created was found to be incorrect. Is there any clarification that might justify these seemingly incompatible points? Perhaps drawing from Leslie, R. A. and Miller’s paper on the subject of the area postrema’s integration with the nucleus of the solitary tract might help elaborate on the current research examining the pathway of emetic responses. The formatting of this section could be improved to make it more like the others. Also, I believe Lithium Chloride falls under the category of spurious captilization. Hassan.zayn (talk) 09:39, 25 November 2009 (UTC)