Adolfo García-Sastre

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Adolfo García-Sastre, Ph.D.
Alma materUniversity of Salamanca
Known for influenza virus research; reconstruction of the extinct 1918 pandemic influenza virus
Scientific career
FieldsMicrobiology
Institutions Mount Sinai Medical Center

Adolfo García-Sastre, Ph.D., is a Professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at The Mount Sinai School of Medicine in New York City. His research into the biology of influenza viruses has been at the forefront of medical advances in epidemiology.[1]

García-Sastre is the author of more than 200 publications.

Biography

García-Sastre earned his Ph.D at the University of Salamanca. His research interest has been focused on the molecular biology of influenza viruses and several other negative-strand RNA viruses. His contributions to his field have included the generation and evaluation of influenza virus vectors as potential vaccine candidates against infectious diseases, including malaria and AIDS, as well as the development (with Dr. Peter Palese) of the first reverse-genetic approaches for the production of infectious recombinant influenza viruses from plasmid DNA – research which has resulted in techniques which are now routinely used with many negative strand RNA viruses. He was the first to identify the biological role of the non-structural NS1 Influenza Protein during infection, the first to describe and provide a molecular analysis of a viral-encoded IFN antagonist among negative strand RNA viruses,[1] and the first to demonstrate that the M1 protein of the influenza virus determines its morphology.[2]

In 2005, as principal investigator of an NIAID program project grant, García-Sastre and his team made headlines when they reconstructed the extinct 1918 pandemic influenza virus.[3]

García-Sastre is an editor for the Journal of Experimental Medicine and PLoS Pathogens, and he sits on the editorial boards of the Journal of Virology, Virology, Virus Research and the Journal of General Virology. In 2001, he co-organized the International Course on Viral Vectors in Heidelberg, Germany, which was sponsored by the Federation of European Biochemical Societies (FEBS), as well as the first Research Conference on Orthomyxoviruses, also in 2001, which was held in the Netherlands and sponsored by the European Scientific Working Group on Influenza.[3] He is a co-founder of Vivaldi Biosciences and a member of the company’s Scientific Advisory board[4] and is the leader of the basic research component on the NIAID-funded Viral Therapeutics and Pathogenesis of the North East Biodefense Center proposal.[5] He was among the first members of the Vaccine Study Section of the National Institutes of Health.[6] He is also principal investigator for the Center for Research on Influenza Pathogenesis, one of five NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS).

Patents

García-Sastre holds 7 patents:[7]

Number Title
20090280144 Recombinant newcastle disease virus RNA expression systems and vaccines
20090203114 Novel methods and Interferon deficient substrates for the propagation of virues
20090061521 Recombinant negative strand RNA virus expression systems and vaccines
20090053264 Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
20090028901 Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
20090010962 Genetically Engineered Swine Influenza Virus and Uses Thereof
20080254060 Genetically Engineered Equine Influenza Virus and Uses Thereof

Publications

Partial List:

  • Immunization with live-attenuated influenza viruses expressing altered NS1 proteins results in potent and protective memory CD8+ T cells responses. Mueller SN, Langley WA, Carnero E, García-Sastre A, Ahmed R. J Virol. 2009 Nov 25. PMID 19939929
  • Hemagglutinin-pseudotyped GFP-expressing influenza viruses for the detection of influenza virus neutralizing antibodies. Martínez-Sobrido L, Cadagan R, Steel J, Basler CF, Palese P, Moran TM, García-Sastre A. J Virol. 2009 Nov 25. PMID 19939917
  • New prospects for the rational design of antivirals. Nistal-Villán E, García-Sastre A. Nat Med. 2009 Nov;15(11):1253-4. PMID 19893557
  • 1918 and 2009 H1N1 influenza are not pathogenic in birds. Babiuk S, Albrecht R, Berhane Y, Marszal P, Richt JA, García-Sastre A, Pasick J, Weingartl H. J Gen Virol. 2009 Nov 4. PMID 19889930
  • Induction of type I interferon by RNA viruses: cellular receptors and their substrates. Baum A, García-Sastre A. Amino Acids. 2009 Nov 1. PMID 19882216
  • An enzymatic virus-like particle assay for sensitive detection of virus entry. Tscherne DM, Manicassamy B, García-Sastre A. J Virol Methods. 2009 Oct 29. PMID 19879300
  • Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Gannagé M, Dormann D, Albrecht R, Dengjel J, Torossi T, Rämer PC, Lee M, Strowig T, Arrey F, Conenello G, Pypaert M, Andersen J, García-Sastre A, Münz C. Cell Host Microbe. 2009 Oct 22;6(4):367-80. PMID 19837376
  • Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment. Steel J, Staeheli P, Mubareka S, García-Sastre A, Palese P, Lowen AC. J Virol. 2009 Oct 14. PMID 19828604
  • Attenuated influenza virus vaccines with modified NS1 proteins. Richt JA, García-Sastre A. Curr Top Microbiol Immunol. 2009;333:177-95. Review. PMID 19768406
  • Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene. Kochs G, Martínez-Sobrido L, Lienenklaus S, Weiss S, García-Sastre A, Staeheli P. J Gen Virol. 2009 Dec;90(Pt 12):2990-4. Epub 2009 Sep 2. PMID 19726611
  • The functional impairment of natural killer cells during influenza virus infection. Guo H, Kumar P, Moran TM, García-Sastre A, Zhou Y, Malarkannan S. Immunol Cell Biol. 2009 Nov-Dec;87(8):579-89. Epub 2009 Sep 1. PMID 19721456
  • Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus. Martínez-Sobrido L, Emonet S, Giannakas P, Cubitt B, García-Sastre A, de la Torre JC. J Virol. 2009 Nov;83(21):11330-40. Epub 2009 Aug 26. PMID 19710144
  • The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. Billharz R, Zeng H, Proll SC, Korth MJ, Lederer S, Albrecht R, Goodman AG, Rosenzweig E, Tumpey TM, García-Sastre A, Katze MG. J Virol. 2009 Oct;83(20):10557-70. Epub 2009 Aug 12. PMID 19706713
  • Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice. Bolland S, García-Sastre A. J Exp Med. 2009 Aug 3;206(8):1647-51. Epub 2009 Jul 27. Review. PMID 19635865
  • Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation. Kuri T, Zhang X, Habjan M, Martínez-Sobrido L, García-Sastre A, Yuan Z, Weber F. J Gen Virol. 2009 Nov;90(Pt 11):2686-94. Epub 2009 Jul 22. PMID 19625461
  • Frias-Stahelin, Giannakopoulos NV, Kikkert M, Taylors, Brigdgena A, ParagasJJ, Richt JA, Rowland RR, Schmaljohn CS, Lenschow DJ, Snijder EJ, García-Sastre A, Virgin HW. Ovarian tumor (OTU)-domain containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell, Host and Microbe 2007; 2: 404-416. PMCID PMC2184509
  • Vigila A, Park MS, Martinezo O, Chua MA, Xioa S, Cros JF, Martinez-Sobrido L, Woo SC, García-Sastre A. Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus. Cancer Research 2007; 67: 8285-8292. PMID 17804743
  • Mibayashim M, Martinez-Sobrido L, Loo YM, Cardenas WB, Gale JR M, García-Sastre A. Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. Journal of Virology 2007; 81: 514-524. PMID 17079289
  • Tumpey TM, Maines TR, Van Hoevenn N, Glaser L, Solorzano A, Pappas C, Cox NJ, Swayne DE, Palese P, García-Sastre A. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 2007; 315: 655-659. PMID 17272724
  • Richt JA, Lekcharoensuk P, Lager KM, Vincent AL, Loiacono CM, Janke BH, Wu WH, Yoon KJ, Webby RJ, Solorzano A, García-Sastre A. Vaccination of pigs against swine influenza viruses using an NS1-truncated modified live virus vaccine. Journal of Virology 2006; 80: 11009-11018. PMID 16943300
  • Tumpey TM, Basler CF, Aguilar PV, Zeng H, Solorzano A, Swayne DE, Cox NJ, Katz JM, Taubenberger JK, Palese P, García-Sastre A, . Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 2005; 310: 77-80. PMID 16210530
  • Munoz-Jordan J, Sanchez-Burgos GG, Laurant-Rolle M, García-Sastre A. Inhibition of interferon signaling by dengue virus. Proceedings of the National Academy of Sciences (U.S.A.) 2003; 100: 14333-14338. PMID 14612562
  • Basler CF, Ried AH, Dybing JK, Janczewski TA, Fanning TG, Zheng H, Salvatore M, Perdue ML, Swayne DE, García-Sastre A, Palese P, Taubenberger JK. Sequence of the 1918 pandemic influenza virus non-structural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proceedings of the National Academy of Sciences (U.S.A.) 2001; 98: 2746-2751. PMID 11226311
  • García-Sastre A. Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative strand RNA viruses. Virology 2001; 279: 375-384. PMID 11162793
  • Fodor E, Devenish L, Engelhardt OG, Palese P, Brownlee GG, García-Sastre A. Rescue of influenza A virus from recombinant DNA. Journal of Virology 1999; 73: 9679-9682. PMID 10516084

References

  1. ^ a b "RetroVirox". Retrieved 2010-03-02.
  2. ^ "Pandemic Influenza: People; Adolfo García-Sastre, Ph.D." Retrieved 2010-03-02. Department of Microbiology, University of Washington
  3. ^ a b "Center for Investigating Viral Immunity & Antagonism". Retrieved 2010-03-02.
  4. ^ "Founders and Scientific Advisory Board Page — Vivaldi Biosciences Inc". Retrieved 2010-03-02.
  5. ^ "Adolfo García-Sastre Lab". Retrieved 2010-03-02. The Mount Sinai Medical Center
  6. ^ "Mount Sinai School of Medicine - Faculty profile". Retrieved 2010-03-02.
  7. ^ "Adolfo García-Sastre - Patents". Retrieved 2010-03-02. patentdocs

External links

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