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Extracerebral decarboxylase inhibitor

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Extracerebral decarboxylase inhibitor is a inhibitory enzyme. It is used to inhibit the decarboxylation of L-DOPA to Dopamine outside the brain, i.e. in the blood. This is primarily co-adminstered with L-DOPA to combat Parkinsons Disease. This also prevents common side-effects such as: nausea and vomiting, as a result of interaction with D2 receptors in the vomiting center (or cheomoreceptor trigger zone) located outside the blood:brain barrier.

Examples include: Carbidopa and Benserazide.

References

Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa. http://www.ncbi.nlm.nih.gov/pubmed/4938431

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