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DNA and RNA codon tables

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The genetic code is traditionally represented as a RNA codon table due to the biochemical nature of the protein translation process. RNA, however, substitutes uracil (U) for thymine (T) as one of its nucleotides, which is one of the main differences between RNA and DNA. However, with the rise of computational biology and genomics, proteins have become increasingly studied at a genomic level. As a result, the practice of representing the genetic code as a DNA codon table has become more popular. The DNA codons in such tables occur on the sense DNA strand and are arranged at a 5' → 3' directionality.

nonpolar polar basic acidic (stop codon)
  2nd base
U C A G
1st base U UUU (Phe/F) Phenylalanine UCU (Ser/S) Serine UAU (Tyr/Y) Tyrosine UGU (Cys/C) Cysteine
UUC (Phe/F) Phenylalanine UCC (Ser/S) Serine UAC (Tyr/Y) Tyrosine UGC (Cys/C) Cysteine
UUA (Leu/L) Leucine UCA (Ser/S) Serine UAA Stop (Ochre) UGA Stop (Opal)
UUG (Leu/L) Leucine UCG (Ser/S) Serine UAG Stop (Amber) UGG (Trp/W) Tryptophan    
C CUU (Leu/L) Leucine CCU (Pro/P) Proline CAU (His/H) Histidine CGU (Arg/R) Arginine
CUC (Leu/L) Leucine CCC (Pro/P) Proline CAC (His/H) Histidine CGC (Arg/R) Arginine
CUA (Leu/L) Leucine CCA (Pro/P) Proline CAA (Gln/Q) Glutamine CGA (Arg/R) Arginine
CUG (Leu/L) Leucine CCG (Pro/P) Proline CAG (Gln/Q) Glutamine CGG (Arg/R) Arginine
A AUU (Ile/I) Isoleucine ACU (Thr/T) Threonine         AAU (Asn/N) Asparagine AGU (Ser/S) Serine
AUC (Ile/I) Isoleucine ACC (Thr/T) Threonine AAC (Asn/N) Asparagine AGC (Ser/S) Serine
AUA (Ile/I) Isoleucine ACA (Thr/T) Threonine AAA (Lys/K) Lysine AGA (Arg/R) Arginine
AUG[A] (Met/M) Methionine ACG (Thr/T) Threonine AAG (Lys/K) Lysine AGG (Arg/R) Arginine
G GUU (Val/V) Valine GCU (Ala/A) Alanine GAU (Asp/D) Aspartic acid GGU (Gly/G) Glycine
GUC (Val/V) Valine GCC (Ala/A) Alanine GAC (Asp/D) Aspartic acid GGC (Gly/G) Glycine
GUA (Val/V) Valine GCA (Ala/A) Alanine GAA (Glu/E) Glutamic acid GGA (Gly/G) Glycine
GUG (Val/V) Valine GCG (Ala/A) Alanine GAG (Glu/E) Glutamic acid GGG (Gly/G) Glycine
A The codon ATG both codes for methionine and serves as an initiation site: the first ATG in a DNA's coding region is where translation into protein begins.[1]
A Mapping of Amino Acids and Stop Signals to DNA Codons
Amino Acid/Signal Codons Amino Acid/Signal Codons
A GCU, GCC, GCA, GCG C UGU, UGC
D GAU, GAC E GAA, GAG
F UUU, UUC G GGU, GGC, GGA, GGG
H CAU, CAC I AUU, AUC, AUA
K AAA, AAG L UUA, UUG, CUU, CUC, CUA, CUG
M AUG N AAT, AAC
P CCU, CCC, CCA, CCG Q CAA, CAG
R CGU, CGC, CGA, CGG, AGA, AGG S UCU, UCC, UCA, UCG, AGU, AGC
T ACU, ACC, ACA, ACG V GUU, GUC, GUA, GUG
W UGG Y UAU, UAC
START AUG STOP UAA, UGA, UAG

See also

References

  1. ^ Nakamoto T (2009). "Evolution and the universality of the mechanism of initiation of protein synthesis". Gene. 432 (1–2): 1–6. doi:10.1016/j.gene.2008.11.001. PMID 19056476. {{cite journal}}: Unknown parameter |month= ignored (help)