Cho Zang-hee
Education
B.Sc, Electronics, College of Engineering, Seoul National University, Seoul, Korea, 1960
M.Sc. Electronics, Graduate School, Seoul National University, Seoul, Korea, 1962
Ph.D. Applied Physics, Institute of Physics, Uppsala university, Uppsala, Sweden, 1966
Fil.D(Docent). Nuclear Physics, Institute of Physics, Stockholm University, Stockholm, Sweden, 1972
Work
Dr. Zang-Hee Cho developed the Ring-PET and BGO scintillation detector for PET in 1970’s for the first time in the world, both of which made major contribution to the modern PET scanner now widely in use from the detection of the early stage CANCERs to NEUROSCIENCE research. More recently, Professor Cho developed the first "PET-MRI" fusion molecular imaging device for the neuro-molecular imaging. This was primarily aimed at the Neuroscience research and study of Neurodegenerative diseases, which are two most crucial research topics in current neuroscience and brain research today.
PET has opened the era of the “MOLECULAR” Imaging for medicine and neuroscience such as detection of neural activities involved in neuro-transmitters and receptors as well as metabolic functions. These are the key elements that control human deceases and cognitive behaviors. minds and diseases, such as the depression and dementia (see the attachment for the further elaborations).
More specifically, Prof. Cho developed the First Ring-PET (1) scanner in 1975 and subsequently introduced the new scintillation detector BGO (2) for PET in 1977, both of which revolutionized the modern PET scanners today which are widely in use from the detection of the early stage cancers to neuroscience research. His invention of the array of ring structured BGO detector and related image reconstruction algorithms are now considered as milestones for the PET scanners to have advanced into the clinical practice from the laboratory. More recently, Prof. Cho developed the first ” PET-MRI” fusion molecular imaging device (3)for neuro-molecular imaging research primarily aimed at the Neuroscience research and study of Neurodegenerative diseases.
PET opened the era of the “Molecular” imaging for the Neuroscience as well as for early diagnosis of “Cancer”. As compared to other medical imaging modalities such as MRI and CT, PET can detect neuronal activities related with neuro-transmitters and receptors. It can also sense early molecular-genetic evolution of DNA in cancer cells with unparalleled high sensitivity(see the attachment for the further elaborations).
Key Words
- Ring-PET : Ring type of Positron Emission Tomograph
- BGO : Bismuth Germanate Oxygen, then a new high atomic number scintillation detector for PET
- PET-MRI : PET and MRI combined Molecular Fusion Imaging System
Key Publications
1. Cho, ZH., Chan, JK. and Eriksson, L., "Circular ring transverse axial positron camera for 3-D reconstruction of radionuclides distribution", IEEE Trans Nucl. Sci, NS-23, 613-622, 1976.
- Cho, ZH., Eriksson, L. and Chan, JK. "A circular ring transverse axial positron camera“ in Reconstruction Tomography in Diagnostic Radiology and Nuclear Medicine Symposium, Puerto Rico, April 1975, and book “ Diagnostic Radiology and Nuclear Medicine”, 393-421, 1977, University Park Press, Baltimore(Ed. by Ter-Pogossian et al).
2. Cho, ZH. and Farukhi, MR., "Bismuth Germanate (BGO) as a potential scintillation detector in positron cameras", J Nucl Med, 18, 840-844, 1977.
3. Cho, ZH, Y.D. Son, H.K. Kim, K.N. Kim, S.H. Oh, J.Y. Han, I. K. Hong, and Y. B Kim. A fusion PET-MRI system with a high- resolution research tomography-PET and ultra high field 7.0 T-MRI for the molecular-genetic imaging of the brain. Proteomic, Vol. 8, No. 6, 1302-1323, 2008
Awards
Honors and Awards
Honors:
Member, The US National Academy of Sciences - Institute of Medicine, USA, 1997-present, Washington D.C. USA
Member, The National Academy of Sciences, Republic of Korea, l998 – 2006 Seoul, Korea
Fellow, Third World Academy of Sciences, 1991, Trieste, United Nation (Italy)
Member, The National Academy of Engineering, Republic of Korea, 1996, Seoul, Korea
Fellow, Korea Academy of Sciences and Technology, 1995, Republic of Korea, Seoul, Korea
Fellow, Institute of Electronic and Electrical Engineers, 1982, New York, N.Y., U.S.A.
Fellow, Institute of Electrical Engineers, 1995, London, UK
Member, National Advisory Council-NCCAM, NIH, Washington D.C., USA, 2004-6
Awards:
1. Distinguished Scientist Award, International Workshop on Physics and Engineering in Medical Imaging; International Workshop on Physics and Engineering in Medical Imaging, March 15-18, 1982, Asilomar, California, USA
2. Grand Science and Engineering Award, Science and Cultural Foundation of Chung-Jinki, August 20, 1984, Seoul, Korea
3. Jacob Javits Neuroscience Award, (NCI) NIH, January; 1, 1984, Washington, D.C., USA
4. Sylvia Sorkin Greenfield Award, American Association of Medical Physicist(AAPM), August 15, 1989, New York, N.Y. USA
5. National Science & Technology Prize (PresidentialAward), Republic of Korea, Feb. 28, 1995, Seoul, Korea
6. National Academy of Science Prize, Korean National Academy of Sciences, Republic of Korea, Sept. l997, Seoul, Korea
7. Science Prize, The Korea Academy of Science and Technology, Seoul, Korea. Feb. 18, 2000
8. Distinguished Faculty Award for Research. Academic Senate, Univ. of Calif. Irvine. January 27, 2004-5, Irvine, Calif. USA
9. National Medal of Honor in Science & Technology, Presidential Award, Republic of Korea, April 21, 2005, Seoul, Korea
10. Distinguished Alumni Award (Kwan-Ak Grand Prize), Seoul National University, Seoul, 2007
Technical Reports
Major Publications Related to PET & PET- MRI
PET Algorithms
1. Cho ZH, General Views on 3-D Image Reconstruction and Computerized Transverse Axial Tomography. IEEE Trans. Nucl. Sci. NS-21, No. 3, 1974.
2. Cho, ZH. and Ahn, I., "Computer algorithm for tomographic image reconstruction with x-ray transmission scan", Computer in Biomedical Res, 8, 8, 1974.
PET Physics
3. Cho, ZH., Chan, JK., Eriksson, L., Singh, M., Graham, S., Macdonald, WS. and Yano, Y., "Positron ranges obtained form biomedically important positron emitting radionuclides", J Nucl Med, 16, 1174-1176, 1975.
PETSystem
4. Cho, ZH., Chan, JK. and Eriksson, L., "Circular ring transverse axial positron camera for 3-D reconstruction of radionuclides distribution", IEEE Trans Nucl Sci, NS-23, 613-622, 1976.
5. Cho, ZH., Cohen, MB., Singh, M., Chan, J., Eriksson, L., Spolter, L. and MacDonald, NS., "Performance and evaluation of a circular ring transverse axial positron camera", IEEE Trans Nucl Sci, NS-24, 532-542, 1977.
6. Cho, ZH., Eriksson, L. and Chan, JK., "A circular ring transverse axial positron camera" in Reconstruction Tomography in Diagnostic Radiology and Nuclear Medicine Symposium, Puerto Rico, April 1975, and in the book “ Diagnostic Radiology and Nuclear Medicine”, 393-421, 1977, University Park Press, Baltimore (Ed. by Ter-Pogossian MM).
PET Detector
7. Cho, ZH. and Farukhi, MR., "Bismuth Germanate (BGO) as a potential scintillation detector in positron cameras", J. Nucl Med, 18, 840-844, 1977.
MRI&PETAlgorithms
8. Cho, ZH., Kim, HS., Song, HB. and Cumming, J., "Fourier transform nuclear magnetic resonance tomographic imaging", Proc of IEEE (Invited paper), 79(10), 1152-1173, 1982
9. Cho, ZH., Hong, KS. and Hilal, SK., "Spherical positron emission tomography S-PET-I performance analysis", Nucl Instrum & Meth,225, 422-438, 1984.
10. Cho ZH, E.X. Wu, S.K. Hilal; Weighted Backprojection Approach to Cone-Beam 3-D Projection Reconstruction for Truncated Spherical Detection Geometry. IEEE Trans. Med. Imag. 13(1), 110-121, 1994.
PET-MRI Fusion
11. Cho, ZH, Y.D. Son, H.K. Kim, K.N. Kim, S.H. Oh, J.Y. Han, I.K. Hong, and Y.B. Kim. A Hybrid PET-MRI: An Integrated Molecular-Genetic Imaging System with HRRT-PET and 7.0 T-MRI. IJIST., Vol. 17, 252-265, 2007
12. Cho, ZH, Y.D. Son, H.K. Kim, K.N. Kim, S.H. Oh, J.Y. Han, I. K. Hong, and Y. B Kim. A fusion PET-MRI system with a high-resolution research tomography-PET and ultra high field 7.0 T-MRI for the molecular-genetic imaging of the brain. Proteomic, Vol. 8, No. 6, 1302-1323, 2008
13. Cho, ZH, Y.D. Son, H.K. Kim, S.T. Kim, S.Y. Lee, Je-Geun Chi, C.W. Park, and Y.B. Kim. Substructural Hippocampal Glucose Metabolism Observed on PET/MRI. J. Nucl. Med. Vol. 51. No. 10, Oct. 2010
See also
Research and / or Professional Experiences of Professor Z.H.Cho
2004–Present University Professor, Neuroscience Research Institute, Gachon Medical School, Inchon, Korea
2006–Present Professor Emeritus, Radiological Sciences and Psychiatry and Human Behavior, University of California, Irvine, California, USA
1985-2006 Professor, Radiological Sciences and Psychiatry and Human Behavior, University of California, Irvine, California, USA
1995-1997 Visiting Endowed Chair Professor, Korea Advanced Institute of Science and Technology, Seoul, Korea
1979-1985 Professor of Radiology (Physics) and Co-Director of Imaging Research Center, Columbia University, New York, New York, USA
1972-1978 Associate Research Physicist and Adjunct Assoc. Professor, Applied Science & Engineering, University of California, Los Angeles, USA
1972-1976 Associate Professor (Docent) of Physics, Institute of Physics, University of Stockholm, Stockholm, Sweden.
1970-1971 Visiting Scientist, Wallenberg Fellow, Brookhaven National Laboratory, Upton, Long Island, New York, USA
1966-1971 Research Staff, Swedish Atomic Research Council, Institute of Physics, University of Stockholm, Sweden.
Major Research Interests
Mathematics and Algorithms, X-ray CT,, Positron Emission CT., Nuclear Magnetic Resonance CT.
functional MRI(fMRI), PET-MRI Fusion Molecular Imaging, Neuroimaging and Neuroscience
References
- Professor Richard Ernst,
- Physical Chemistry, ETH(Federal Institute of Technology), Zurich, Switzerland Nobel laureate in Chemistry for his contribution to the NMR and MRI Imaging in 1992
- Professor Seiji Ogawa,
- Tohuku University, Sendai, Japan
- Japan Prize Winner for his contribution to the functional MRI in 2005
- Professor Gordon Brownell
- MIT-Harvard Program, PET-Center, Massachusett General Hospital, Boston, Mass, USA
- Professor Frank Jolesz,
- Brigham & Woman’s Hospital, Harvard Medical School, Boston, Mass. USA
External Links
See Google : Neuroscience Research Institute, Gachon University, Korea
Other Academic Activities
Editorship, Members of Editorial Board and Steering Committee on International Scholarly Journals.
1. Editor in Chief, International Journal of Imaging Systems & Technology, John Wiley & Sons, New York, N.Y., 1993-2011
2. Editorial Board ; Magnetic Resonance in Medicine, Academic Press, San Diego, New York, 1984-90
3. Steering Committee IEEE Trans. on Medical Imaging, IEEE Press, New York, NY, 1985-93
4. Steering Committee : IEEE Trans. on Nuclear Science, IEEE Press, New York, NY, 1985-92
5. Editorial Board : Computerized Medical Imaging and Graphics, Pergamon Press, New York, NY, 1988-
6. Editorial Board : Physics in Medicine and Biology, Institute of Physics, London, England, 1993
7. Editorial Board : International Journal of Imaging Systems and Technology, John Wiley & Sons, New York, NY, 1989-93
Summary Academic Activities: Special Issues, Peer Review Publications, Invited Talks, and Books
I. Special Issues edited (10)
II. Journal Publications (In Refereed and Archival Journals - Approximately 230)
III. Conference Papers and Abstract (Approximately 300-400)
IV. Invited Talks (Keynote, Special Lecture, and Invited Lecture ; Approximately 300)
V. Book ; Graduate Text Book : Foundation of Medical Imaging ( John Wiley & Sons ), 1993
VI. Book : 7 Tesla MRI Brain Atlas- In-vivo Atlas with Cryomacrotome Correlation (Springer, New York, Dordrecht, Heidelberg, London), 2009 Plus 3 others
Book ; Representative Text & Research Books:
Z.H. Cho, J. Jones, and M. Singh ; Foundation of Medical Imaging ( John Wiley & Sons ), 1993, New York, USA
Z. H. Cho (Editor) ; 7 Tesla MRI Brain Atlas – In-vivo Atlas with Cryomacrotome Correlation (Springer, New York, Dordrecht, Heidelberg, London) 2009