Talk:Small nuclear RNA

Id be keen to have 'small nucleolar RNA' re-instated as a full page again rather than a re-direct merged with small nucleolar RNA? Jennifer_Rfm 12:52, 15 June 2007 (UTC)

This has been done: Small nucleolar RNA. Biolprof (talk) 19:04, 7 February 2013 (UTC)

images

If anyone has some nice labelled images of C/D box or H/ACA box structures please do substitute them for the ones I have added Jennifer_Rfm 14:58, 15 June 2007 (UTC)

course project

I will be improving this page as part of a class project under the supervision of Dr. Lesly Temesvari (Username:LTEMESV) at Clemson University. (Bjstone6 (talk) 14:19, 16 November 2012 (UTC))

All the statements made in this article should contain references to (at the very least) peer edited reviews in the field. —Preceding unsigned comment added by 128.100.134.71 (talk) 21:55, 3 March 2008 (UTC)

updates needed

The article makes at least two claims which need to be corrected.

• That splicing is effected post-transcriptionally. The current consensus is that it is primarily co-transcriptional but some of it takes place post-transcriptionally.
• (Goldstrohm, Aaron C., Arno L. Greenleaf, and Mariano A. Garcia-Blanco. "Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing." Gene 277.1 (2001): 31-47.)
• That the distinction between U2-type and U12-type introns is the consensus sequence at the 5' and 3' splice sites. This is a relic of the initial discovery of the minor spliceosome. This is why the minor spliceosome analogue to the U4/U6 snRNA duplex has 'atac' appended i.e. U4atac and U6atac. This is not necessarily the case and there are several U2-types with AT-AC as well as U12-types with GT-AG (Levine, Aaron, and Richard Durbin. "A computational scan for U12-dependent introns in the human genome sequence." Nucleic acids research 29.19 (2001): 4006-4013; Sheth, Nihar, et al. "Comprehensive splice-site analysis using comparative genomics." Nucleic acids research 34.14 (2006): 3955-3967.).