David R. Soll
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David R. Soll | |
|---|---|
| Born | April 2, 1942 Philadelphia, Pennsylvania, USA |
| Alma mater | University of Wisconsin–Madison |
| Occupation | Biologist |
| Known for | Motion analysis of living cells monoclonal antibody technologies Candida albicans |
| Awards | Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences Lucille K. George Medal |
| Scientific career | |
| Institutions | The University of Iowa Monoclonal Antibody Research Institute Developmental Studies Hybridoma Bank WM Keck Dynamic Images Analysis Facility |
David R. Soll (born April 29, 1942) is a Professor of Biology at the University of Iowa. He is best known for the motion analysis of living cells,[1] the discovery of Candida albicans phenotypic switching[2] and monoclonal antibody technology. He is the current director of the Developmental Studies Hybridoma Bank, Monoclonal Antibody Research Institute, and the WM Keck Dynamic Image Analysis Facility. He is also a member of the board of directors of the Foundation for Monoclonal Antibody Research. He has published over 350 articles in various fields of biomedicine and has received more than 70 grants and contracts, founded four companies, and served on the editorial board as an associate editor or as editor of eight biomedical journals.
Background
Soll was born in South Philadelphia, Pennsylvania and graduated from Central High School (Philadelphia) for boys in 1959. He then attended the University of Wisconsin from 1960 to 1969, receiving a BA, MS and PhD. He then served as a post-doctoral fellow and taught Introductory Biology at Brandeis University. In 1972 he joined the Department of Biology at the University of Iowa, as an Assistant Professor. In 1976 he became an Associate Professor and in 1982 a Full Professor. In 1989 he was awarded the Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences, and in 1989 also became a Full Professor of Dentistry. In 2005, he was elected a Fellow of the American Association for the Advancement of Science (AAAS) and in 2006 a Fellow of the American Academy of Microbiology. In 2009 he was awarded the Lucille K. George Medal from the International Society of Human and Animal Mycology. David Soll was married for 30 years to the late Michele Morice and has three children, Jacob Soll, Samantha Soll and Benjamin Soll.
Discoveries
He is now the Director of the Developmental Studies Hybridoma Bank (DSHB), a NIH National Resource, Director of the W.M. Keck Dynamic Image Analysis Facility, Director of the Monoclonal Antibody Research Institute and on the board of the Foundation for Monoclonal Antibody Research. His research groups now focus on 1) the role of mating and switching in the pathogenesis of Candida albicans, 2) cell motility and the cytoskeleton, 3) advanced monoclonal antibody technology and 4) cancer subgroups and cell surface antigens of cancer stem cells.
- From 1965 to 1970, he worked on the germination of Blastoclondrilla emersonü under the mentorship of David Sonneborn and discovered that complex differentiations can preprogrammed and occur with RNA or protein synthesis1
- From 1972 to 1978, he and colleagues worked on the “accumulation and erasure of morphogenetics information” in D. discoideum7
- In 1979, he formulated the first conditioned methods to analyze timer pathways in development2, 8.
- From 1977 to 1984, he developed pH regulated dimorphism and applied it to study the regulation of the bind-hypha transition in Candida albicans9,10.
- In 1985 and 1987, he and colleagues discovered the first phenotypic switching systems in the pathogenic yeast C. albicans3, 11.
- In 1989, he and Dr. E Voss finished and the U. of Iowa licensed DMS, the Dynamic Motion Analyses System ((DMS) to Motion Analyses Corporation of Santa Rosa, CA. In 1997, Soll and Voss obtained the M.S. patent for DIAS, the next generation of DMS12.
- From 1987 to 1995, he and coworkers developed the first DNA fingerprinting probes for studying the population structure of infection fungi, and in 1995 received a patent for the software DENDRON, which analyzed DNA fingerprints13.
- In 2003, he and coworkers described for the first time, the cell biology of mating of C. albicans14.
- From 1995 to 2004, he and colleagues developed the first 3D dynamic image analysis system (3D-DIAS) for cells and embryos15,16,17.
- From 2005 to present, he and colleagues discovered that C. albicans forms a “pathogenic” biofilm and a “sexual” biofilm depending on the configuration of the mating type locus5,6. Identified the alternative pathways regulating each biofilm18,19.
- From 2011 to present, developed a 3D model for the formation of cancer tumors in 3D and the software to reconstruct and motion analyze the 3D tumors.
Publications
- Planck, M. (1900a). "Über eine Verbesserung der Wienschen Spektralgleichung". Verhandlungen der Deutschen Physikalischen Gesellschaft. 2: 202–204.
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References