CAPZA2
Template:PBB F-actin-capping protein subunit alpha-2 also known as CapZ-alpha2 is a protein that in humans is encoded by the CAPZA2 gene.[1]
Structure
CapZ-alpha2 is a 33.0 kDa protein comprised of 286 amino acids.[2] CAPZA2 is located on human chromosome 7, position q31.2-q31.3.[3] The primary sequence of CapZ-alpha2 contains three C-terminal, regularly spaced leucines at positions 258, 262 and 266 found in consensus sequence of KxxxLxxE/DLxxALxxK/R that are critical for actin binding; these residues are conserved within the CapZ-beta isoform.[4] CapZ-alpha2 is 85% identical to CapZ-alpha1, and differ by a small number of key amino acids; 21 amino acid differences perpetrate isoform specificity.[5] CapZ-alpha2 is expressed in a variety of tissues, and the ratio of CapZ-alpha2 to CapZ-alpha1 varies significantly among different tissues.[6]
Function
Clinical Significance
References
- ^ "Entrez Gene: CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2".
- ^ "Protein sequence of human CAPZA2 (Uniprot ID: P47755)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Retrieved 18 September 2015.
- ^ Barron-Casella, EA; Torres, MA; Scherer, SW; Heng, HH; Tsui, LC; Casella, JF (15 September 1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families". The Journal of biological chemistry. 270 (37): 21472–9. PMID 7665558.
- ^ Barron-Casella, EA; Torres, MA; Scherer, SW; Heng, HH; Tsui, LC; Casella, JF (15 September 1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families". The Journal of biological chemistry. 270 (37): 21472–9. PMID 7665558.
- ^ Hart, MC; Korshunova, YO; Cooper, JA (1997). "Vertebrates have conserved capping protein alpha isoforms with specific expression patterns". Cell motility and the cytoskeleton. 38 (2): 120–32. PMID 9331217.
- ^ Hart, MC; Korshunova, YO; Cooper, JA (1997). "Vertebrates have conserved capping protein alpha isoforms with specific expression patterns". Cell motility and the cytoskeleton. 38 (2): 120–32. PMID 9331217.