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William S. Sly

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William S. Sly
Born(1932-10-19)October 19, 1932
NationalityUnited States
Alma materSt. Louis University
Known forSly Syndrome
SpouseMargaret Ann Sly
Children7
AwardsNational Academy of Sciences
Passano Foundation Award
Peter H. Raven Lifetime Achievement Award
Burlington Northern Foundation Faculty Achievement Award
Coriell Medal in Scientific Achievement
IBIS Marcel Simon Award
Scientific career
FieldsBiochemistry
InstitutionsSt. Louis University
Washington University in St. Louis

William S. Sly (October 19, 1932 – ) is an American biochemist. Born in East St. Louis, Illinois, Sly did his undergraduate work at Saint Louis University and obtained his medical degree from the university’s School of Medicine in 1957. He received training at Washington University’s School of Medicine, the National Institutes of Health, the Centre National de la Recherche Scientifique in Paris and the University of Wisconsin, before joining the Washington University, School of Medicine faculty in 1964. In 1984, he was appointed the Alice A. Doisy Professor and chairman of the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University. In 2007, he was also named the inaugural holder of the James B. and Joan C. Peter Endowed Chair in Biochemistry and Molecular Biology. He is a member of the National Academy of Sciences since 1989.

Dr. Sly is an internationally renowned physician and scientist who has contributed greatly to the understanding of inborn errors of metabolism. He and his research group described the first patient with mucopolysaccharidosis VII, later termed Sly syndrome in 1973. This research provided the rationale for enzyme replacement therapy in Gaucher’s disease, the most common lysosomal storage disease, and has encouraged the development of enzyme replacement for other lysosomal diseases. In addition, Dr. Sly identified the first inherited deficiency of a human carbonic anhydrase and characterized the associated bone, brain, and kidney disease. Also, he has conducted extensive research on hereditary hemochromatosis.

Sly received an honorary doctor of science degree from Washington University in St. Louis in 2007.[1]

Sly received an honorary doctor of science degree from Washington University in St. Louis in 2007.

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