User:Nathanneuro/sandbox
Project proposal: open channel block
=Lead=
=Identity (structure)=
Overview article-The hitchhiker’s guide to the voltage-gated sodium channel galaxy-Christopher Ahern
=Physiology (lewis)=
Role of open channel block as antagonist to various channels
specificity of molecules
kinetics of open channel block (Open Channel Block and Beyond - Meyer B. Jackson)
=Therapeutical Uses=
=pharmacology=
List major classes of channel blockers that affect the pore (sodium, chloride, potassium, calcium).
Potential diseases that could be treated or are treated with open channel blockers
Cystic Fibrosis(Cystic Fibrosis transmembrane conductance regulator chloride channel blockers - Linsdell, P) Alzheimer’s Disease (management of moderate to severe Alzheimer’s disease; focus on memantine - Dominguez E.)
=biomarkers=
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