Philip L. Townes

Philip L. Townes, MD, PhD
Born	February 27, 1927 Salem, Massachusetts
Died	April 1, 2017 (Age 90) Worcester, Massachusetts
Nationality	American
Education	Harvard University, 1948 (AB), University of Rochester, 1952 (PhD), 1959 (MD)
Occupation(s)	Physician (pediatrics), human geneticist, embryologist, developmental biologist
Years active	1953 - 1995
Known for	Townes-Brocks Syndrome Differential adhesion hypothesis
Notable work	Directed movements and selective adhesion of embryonic amphibian cells. (1955). J. Exp. Zool.128:53-120 (1)
Spouse	Marjorie G. Townes
Children	Elizabeth Ann Townes Susan Jane Townes David Andrew Townes
Relatives	Eloise Grace Townes (granddaughter) Maya Danielle Townes (granddaughter)

Philip L. Townes, MD, PhD (February 18, 1927 - April 1, 2017) was an American physician, human geneticist, embryologist and developmental biologist who identified Townes-Brocks Syndrome (along with Eric Brocks) in 1972 while a Professor of Pediatrics at the University of Rochester in Rochester, New York. As a graduate student, his pioneering work with Johannes Holtfreter served as the basis for the differential adhesion hypothesis (DAH) that explains cellular moment and differentiation during morphogenesis. (2)

Early Life and Education

Philip Leonard 'Len' Townes was born February 18, 1927 in Salem, Massachusetts to Saul and Lillian (Kravetsky) Townes. He graduated from Salem High School and attended Harvard University before enlisted in the United States Navy during World War II. After an honorable discharge at the end of the War, he completed his studies at Harvard, earning an AB in 1948. He went on to the University of Rochester, earning a PhD in 1952 under the mentorship of Johannes Holtfreter, and earning an MD in 1959. He completed his residency training in pediatrics at the University of Rochester in 1964 and served as Chief Resident in 1965.

Research

As a graduate student working in the laboratory of Johannes Holtfreter, Townes pioneered a technique for studying the kinetic and morphogenetic phenomena, subsequent to the combination of two or more well defined cell types, that revolutionized the understanding of morphogenesis, and serves as the basis for the differential adhesion hypothesis. (2) With this technique, areas of embryonic tissue (mostly cell layers from amphibian neurulae) were teased from the embryos with glass needles. Once separated they could be recombined with one another. This demonstrated that in the process of sorting out, the different cell types exhibited a cell-specific tendency to arrange themselves in a definite tissue pattern that corresponded to that in normal development. The work was published as Townes' thesis in the classic paper in embryology and developmental biology, 'Directed movements and selective adhesion of embryonic amphibian cells' in 1955 in the J. Exp. Zool. 128:53-120. (1)

Medical Career

Townes was a member of the faculty at the University of Rochester in the Departments of Anatomy and Pediatrics from 1952-1979. He was named Professor of Pediatrics in 1966 and served as the Chairman of the Division of Genetics and Director of the Genetic Clinic from 1966-1979. He served as an honorary research assistant at the University College, London, England from 1965-1966. In 1972, he identified a rare inherited syndrome in a father and five of his seven children, characterized by the triad of imperforate anus, dysplastic ears, and thumb malformations, subsequently know as Townes-Brocks Syndrome. Townes-Brocks Syndrome was later found to be caused by a mutation in the DACT1 gene on chromosome 14q23.

Townes was a member of the faculty and Professor of Pediatrics and Obstetrics and Gynecology at the University Massachusetts Medical School from 1979-1995 where he directed the Genetic Clinic and the Cytogenetics Laboratory. In 1995 he retired to become an emeritus Professor of Pediatrics and Obstetrics and Gynecology.

Personal

Philip Townes was married to Margorie Townes from 1956 until his death in 2017. He has three children (Elizabeth Ann, Susan Jane, and David Andrew) and two grandchildren (Eloise Grace and Maya Danielle).

References

(1) http://onlinelibrary.wiley.com/doi/10.1002/jez.1401280105/full

(2) http://onlinelibrary.wiley.com/doi/10.1002/jez.a.114/epdf