Mark van der Giezen
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Mark van der Giezen is Senior Lecturer (Associate Professor) in Evolutionary Biochemistry, Biosciences, University of Exeter, UK.
van der Giezen investigates adaptations of microbial eukaryotes to life under anoxia, or low oxygen. He discovered mitochondrial remnants (mitosomes) in the human intestinal parasite Giardia intestinalis [1], an organism until then considered to be one of the most primitive eukaryotes. This discovery called for re-assessment of the evolution of mitochondria.
van der Giezen's research has demonstrated that several unusual organelles are in fact mitochondria EMBO J (2002) 21: 572-579; Mol Biol Evol (2003) 20: 1051-1061. More recently, he has conducted large dataset analyses of microbial eukaryotes (Curr Biol (2008) 18: 580-585). His current work includes next-generation sequencing projects, and he is involved in several eukaryotic genome projects. He annotated and curated 10% of the Emiliania huxleyi genome (Nature (2013) 499: 209-213) and other genomes are currently in progress including crustacean and fish parasite genomes. Most recently, he was involved in the genome of the most common microbial eukaryote found in human intestines (PLoS Biology (2017) 15(9): e2003769). He uses large-scale RNASeq analyses for protists that are difficult to culture (Curr Biol (2014) 24: 1176–1186).
References
- ^ Nature (2003) 426: 172-176