Ellen Heber-Katz

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Ellen Heber-Katz
Born
Philadelphia, Pennsylvania
Alma materUniversity of Pennsylvania (PhD)
University of Wisconsin–Madison (BA)(MS)
AwardsNational Institutes of Health Eureka Grant
National Cancer Institute’s Director’s Provocative Question Initiative Grant
Scientific career
FieldsImmunology, Microbiology
InstitutionsLankenau Institute for Medical Research
The Wistar Institute

Ellen Heber-Katz is an American immunologist/regeneration biologist who is professor at Lankenau Institute for Medical Research (LIMR).[1] She is an immunologist who investigates mammalian regeneration,[2][3][4][5][6] having discovered the ability of the MRL mouse strain to regenerate wounds without scarring and to fully restore damaged tissues. Her work on regeneration has been extended into National Cancer Institute (NCI)-funded studies of novel aspects of breast cancer causation.[7] Her research interests include immunology, regenerative medicine and cancer.[8]

Education and career

Heber-Katz earned her B.A. in microbiology and immunology from the University of Wisconsin-Madison, in 1969, and her M.S. in immunology from the same university in 1972.[9] For her M.S. thesis, she studied the role of reducing agents as a critical factor in cellular immune responses.[10] She then moved to Philadelphia to attend the University of Pennsylvania and was awarded her Ph.D. in immunology in 1976. For her doctoral thesis she demonstrated that single T-cell subsets could respond to both histocompatibility antigens and environmental antigens, establishing the unity of these two branches of the immune response.[11] She was a postdoctoral fellow at the National Institutes of Allergy and Infectious Diseases in the Laboratory of Immunology, discovering the first functional evidence for the T cell–antigen-MHC-Ia tri-molecular complex anticipating the crystal structure.[citation needed]

With the use of genetically inbred mice, Heber-Katz and collaborators dissected the fine molecular details that control the T-cell and macrophage interaction. This "A/5R experiment" confirmed the Determinant Selection Hypothesis concerning the spatial relationships between the histocompatibility I-A and I-E molecules on the surface of antigen- presenting cells, the bound antigen and the recognition structure of the T-cell receptor.[12]

Immunology studies

Heber-Katz was recruited to the Wistar Institute, Philadelphia, by its director and vaccinologist Hilary Koprowski. While at Wistar, Heber-Katz developed the first vaccine capable of eliciting a purely T-cell response that was fully protective against a lethal challenge of herpes simplex virus in the complete absence of antibodies, and she patented a generic structure for a purely T-cell activating vaccine.[13]

Broadening her immunology studies into the area of autoimmunity, Heber-Katz discovered that particular autoimmune diseases were under the control of delimited and separable T-cell receptor subsets (the V-region disease hypothesis).[14] It was during the course of an autoimmunity study that Heber-Katz discovered the regeneration trait of the MRL mouse,[15][16][17] which has largely occupied her research program for the past 15 years.

In 2014, Heber-Katz brought her lab to LIMR, which is part of Main Line Health, a non-profit health system serving portions of Philadelphia and its surrounding suburbs.[18] She also is a member of the Molecular Biology and Genetics Program at the Sidney Kimmel Cancer Center at Thomas Jefferson University.[citation needed] She holds five patents for vaccines and wound healing. [19]

Mammalian regeneration

While working at the Wistar Institute in 1996, Heber-Katz discovered the unusual ability of the MRL mouse strain (which had been used for almost 50 years in autoimmunity research) to regenerate wounds without scarring and to fully restore damaged tissues, including cartilage and hair follicles, an ability not normally seen in mammals. Heber-Katz's discovery initiated the study of multi-organ/multi-tissue regeneration beyond amphibian biology to a medically significant species of mammal.[20][21][22][23][24][25][26][27][28][29][30][31] Her move into this field led to her recognition[by whom?] as a thought leader in the field of regenerative biology.[32][33]

References

  1. ^ "Ellen Heber-Katz, PhD - LIMR - Researcher Profile". LIMR. Retrieved 2016-04-02.
  2. ^ "Tendon regeneration and scar formation: The concept of scarless healing". Journal of Orthopaedic Research. 33: 823–831. doi:10.1002/jor.22853. Retrieved 2016-04-02.
  3. ^ Zhang, Yong (2015-06-03). "Drug-induced regeneration in adult mice | Science Translational Medicine". Stm.sciencemag.org. Retrieved 2016-04-02.
  4. ^ Gourevitch, D; Kossenkov, AV; Zhang, Y; Clark, L; Chang, C; Showe, LC; Heber-Katz, E (2015-09-28). "Inflammation and Its Correlates in Regenerative Wound Healing: An Alternate Perspective". Adv Wound Care (New Rochelle). 3: 592–603. doi:10.1089/wound.2014.0528. PMC 4152783. PMID 25207202.
  5. ^ Edwards, RG (2015-09-28). "From embryonic stem cells to blastema and MRL mice". Reprod. Biomed. Online. 16: 425–61. PMID 18339268.
  6. ^ "Case Closed: A Fluky Finding Raises Hopes for Mending Wounds". Scientific American. Retrieved 2016-04-02.
  7. ^ Nathan A. Berger. "Murine Models, Energy Balance, and Cancer: 9783319167329: Medicine & Health Science Books @". Amazon.com. Retrieved 2016-04-02.
  8. ^ "From Immunity and Vaccines to Mammalian Regeneration". The Journal of Infectious Diseases. 212. 2015. Retrieved 2016-04-03.
  9. ^ "http://www.limr.org/lmr/Page.asp?out=html&searchType=Faculty&PageID=LMR000321"
  10. ^ Click, RE (2015-09-28). "A review: alteration of in vitro reproduction processes by thiols —Emphasis on 2-mercaptoethanol". J. Reprod. Dev. 60: 399–405. doi:10.1262/jrd.2014-055. PMC 4284312. PMID 25087867.
  11. ^ D. B. Wilson; E. Heber-Katz; J. Sprent; J. C. Howard* (1977-01-01). "On the Possibility of Multiple T-cell Receptors". Symposium.cshlp.org. Retrieved 2016-04-02.
  12. ^ Heber-Katz, E; Hansburg, D; Schwartz, RH (2015-09-28). "The Ia molecule of the antigen-presenting cell plays a critical role in immune response gene regulation of T cell activation". J. Mol. Cell. Immunol. 1: 3–18. PMID 6101061.
  13. ^ "Patent US5837249 - Method for generating an immunogenic T cell response protective against a virus - Google Patents". Google.com. Retrieved 2016-04-02.
  14. ^ Heber-Katz, E; Acha-Orbea, H (2015-09-28). "The V-region disease hypothesis: evidence from autoimmune encephalomyelitis". Immunol. Today. 10: 164–9. doi:10.1016/0167-5699(89)90174-6. PMID 2663017.
  15. ^ Lise Desquenne Clark; Robert K. Clark; Ellen Heber-Katz (July 1998). "A New Murine Model for Mammalian Wound Repair and Regeneration" (PDF). Clinical Immunology and Immunopathology. 88: 33–45. Retrieved 2016-04-03.
  16. ^ Morelle, Rebecca (2006-04-11). "Science/Nature | Mouse sheds light on regeneration". BBC News. Retrieved 2016-04-02.
  17. ^ "The super super-healing MRL mouse strain". Frontiers in Biology. 7: 522–538. doi:10.1007/s11515-012-1192-4. PMC 3806350.
  18. ^ "Archived copy". Archived from the original on March 6, 2016. Retrieved March 30, 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)CS1 maint: archived copy as title (link)
  19. ^ https://patents.google.com/?inventor=Heber-Katz
  20. ^ Cheverud, JM; Lawson, HA; Bouckaert, K; Kossenkov, AV; Showe, LC; Cort, L; Blankenhorn, EP; Bedelbaeva, K; Gourevitch, D; Zhang, Y; Heber-Katz, E. "Heredity - Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line". Heredity. 112: 508–518. doi:10.1038/hdy.2013.133. PMC 3998788. PMID 24569637.
  21. ^ "ARTICLES | Physiological Genomics". Physiolgenomics.physiology.org. 2013-06-01. Retrieved 2016-04-02.
  22. ^ Heber-Katz, E; Zhang, Y; Bedelbaeva, K; Song, F; Chen, X; Stocum, DL (2015-09-28). "Cell cycle regulation and regeneration". Curr. Top. Microbiol. Immunol. 367: 253–76. doi:10.1007/82_2012_294. PMID 23263201.
  23. ^ "Heritability of articular cartilage regeneration and its association with ear wound healing in mice". Arthritis & Rheumatism. 64: 2300–2310. 2012-01-24. doi:10.1002/art.34396. PMC 3360138. Retrieved 2016-04-02.
  24. ^ Arthur, LM; Heber-Katz, E (2015-09-28). "The role of p21 in regulating mammalian regeneration". Stem Cell Res Ther. 2: 30. doi:10.1186/scrt71. PMC 3152998. PMID 21722344.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  25. ^ Vorotnikova, E; McIntosh, D; Dewilde, A; Zhang, J; Reing, JE; Zhang, L; Cordero, K; Bedelbaeva, K; Gourevitch, D; Heber-Katz, E; Badylak, SF; Braunhut, SJ (2015-09-28). "Extracellular matrix-derived products modulate endothelial and progenitor cell migration and proliferation in vitro and stimulate regenerative healing in vivo". Matrix Biol. 29: 690–700. doi:10.1016/j.matbio.2010.08.007. PMID 20797438.
  26. ^ Bedelbaeva, K; Snyder, A; Gourevitch, D; et al. (March 2010). "Lack of p21 expression links cell cycle control and appendage regeneration in mice". Proceedings of the National Academy of Sciences. 107: 5845–5850. doi:10.1073/pnas.1000830107. PMC 2851923. PMID 20231440. Retrieved 2016-04-03.
  27. ^ Naviaux, RK; Le, TP; Bedelbaeva, K; Leferovich, J; Gourevitch, D; Sachadyn, P; Zhang, XM; Clark, L; Heber-Katz, E (2015-09-28). "Retained Features of Embryonic Metabolism in the Adult MRL Mouse". Mol. Genet. Metab. 96: 133–44. doi:10.1016/j.ymgme.2008.11.164. PMC 3646557. PMID 19131261.
  28. ^ Ellen Heber-Katz; John Leferovich; Khamilia Bedelbaeva; Dmitri Gourevitch; Lise Clark (2004). "The scarless heart and the MRL mouse" (PDF). The Royal Society. 359: 785–93. doi:10.1098/rstb.2004.1468. PMC 1693365. PMID 15293806. Retrieved 2016-04-03.
  29. ^ Blankenhorn, EP; Troutman, S; Clark, LD; Zhang, XM; Chen, P; Heber-Katz, E. "Sexually dimorphic genes regulate healing and regeneration in MRL mice". Mammalian Genome. 14: 250–260. doi:10.1007/s00335-002-2222-3. PMID 12682777. Retrieved 2016-04-03.
  30. ^ Gourevitch, D; Clark, L; Chen, P; Seitz, A; Samulewicz, SJ; Heber-Katz, E (2003-01-14). "Matrix metalloproteinase activity correlates with blastema formation in the regenerating MRL mouse ear hole model". Developmental Dynamics. 226: 377–387. doi:10.1002/dvdy.10243. PMID 12557216. Retrieved 2016-04-03.
  31. ^ "Regeneration: Stem Cells and Beyond | Ellen Heber-Katz". Springer. Retrieved 2016-04-03.
  32. ^ Kristen Philipkoski. "Mighty Mice Regrow Organs". Archive.wired.com. Retrieved 2016-04-03.
  33. ^ "Ellen Heber-Katz: The MRL mouse - how it regenerates and how we might do the same on Vimeo". Vimeo.com. 2011-01-23. Retrieved 2016-04-03.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Ellen_Heber-Katz&oldid=843828351"