User talk:Ken Gillman

Signature

Hello. Please do not sign your edits to articles. Signatures are meant to be used on talk pages only. See Ownership of articles for more information. Thanks. Khatru2 01:23, 24 September 2006 (UTC)[reply]

MAOIs

hi ken-- first the standard welcome message, with good links you should check out. maybe you've gotten this already, but, here it is again, just in case . . .

Welcome!

Hello, Ken Gillman, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are some pages that you might find helpful:

I hope you enjoy editing here and being a Wikipedian! Please sign your name on talk pages using four tildes (~~~~); this will automatically produce your name and the date. If you need help, check out Wikipedia:Questions, ask me on my talk page, or place {{helpme}} on your talk page and someone will show up shortly to answer your questions. Again, welcome!

i'd highly recomend reading through that stuff before making substantive edits to pages, such as you did with monoamine oxidase inhibitor. ie, there are ways we cite stuff, ways we use headers to seperate sections, ways we link to other articles, which you don't seem aware of. also, much of the information you added was redundant; at the very least, it needs to be integrated with the already existent article.

cheers --heah 19:12, 24 September 2006 (UTC)[reply]

Thank you. I appreciate the points made above and that there are formatting issues I have no understanding of. Because I was unable to deal with those procedures I thought it was better to contribute some material and let someone else edit it if they chose to. I simply do not have the time or ability to do that at present.

However it is important for it to be known that some of the material in this current version is significantly at odds with evidence-based science. As far as I am able to see the current version has no scientific citations and makes some important and contentious statements that absolutely require quality citations, if they are supportable. e.g. ' so increasing the available stores.' I do not believe a citation can be produced to support that statement, neither do think it is correct. I have read a substantial proportion of all scientific papers produced about MAOIs and do not recall data that would support that.

'In addition to reversibility, MAOIs differ by their selectivity of the MAO receptor. Older MAOIs inhibit both MAO-A and MAO-B equally, but newer MAOIs have been developed that target one over the other.'

Again, this is unreferenced as far as I can see, and significantly at odds with history. The original selective irreversible MAOIs, clorgyline and pargyline-, were synthesised decades prior to moclobemide and used clinically.

Dangers could be improved 'hyperserotonemia if foods containing tryptophan are consumed'- again, I don't see a citation to support this and am confident that no such evidence exists.

'The exact mechanism by which tyramine causes a hypertensive reaction is not well understood' Not many Neuropharmacologists would agree with this: it is understood, and if you wish to read about it you will find quite detailed information on my website which cites the relevant scholarly articles and summarises them.

As far as a diet is concerned it might be useful for someone to look carefully at the material I contributed: it is the most comprehensively referenced list currently in existence, either on the internet, or in any scholarly scientific article.

The current contribution has much anecdotal and unreferenced material.

It is unlikely that I shall have the time, or ability, to return to this issue for some months. Perhaps it is for someone else to decide if a link to my website giving information about diet is appropriate on wiki Note my website is being reconstructed and that process is likely to be complete within a month from now. Good luck to someone; I will try to return to this issue in while.Ken Gillman 00:00, 25 September 2006 (UTC)[reply]

Thank you for your contribution to Mirtazapine

Thank you for your contribution to the Mirtazapine article. You have raised a very interesting point. You are certainly a very well qualified person to be contributing to articles on wikipedia concerning your field of work. I hope you continue to contribute to articles on wikipedia. I have changed the format of the reference you gave in your entry on Mirtazapine to the correct format. But I realise that this could be due to your speech to text software. --Benjaminevans82 23:43, 12 October 2006 (UTC)[reply]

Thank you for edit, much appreciated. Ken Gillman 08:12, 26 November 2006 (UTC)[reply]