L-Aspartic-4-semialdehyde
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Aspartate Pathway
The aspartate pathway is an amino acid metabolic pathway present in bacteria and plants that deal with converting aspartate to other amino acids through a series of reactions and intermediates. L-Aspartate 4-Semialdehyde serves as one of the first intermediates in the pathway and as an important step of differentiation in the pathway.[2]
L-Aspartate-4-semialdehyde is synthesized by the enzyme aspartate semialdehyde dehydrogenase, which catalyzes the following reversible chemical reaction:
- L-4-Aspartyl phosphate + NADPH + H+ L-aspartate-4-semialdehyde + NADP+ + phosphate
Once L-aspartate-4-semialdehyde is synthesized, the molecule can then progress down a number of pathways. One possible pathway requires L-aspartate-4-semialdehyde to undergo a reaction catalyzed by the enzyme dihydropicolinate synthase in order to form the molecule dihydrodipicolinate. This reversible chemical reaction is shown below:[3]
- L-Aspartate-4-semialdehyde + pyruvate dihydrodipicolinate + H2O
Once dihydrodipicolinate is synthesized, it can continue down the metabolic pathway leading to the synthesis of lysine. [4] Other than the lysine biosynthetic pathway, L-aspartate-4-semialdehyde can also undergo a reversible reaction catalyzed by the enzyme homoserine dehydrogenase. This reaction, which turns L-aspartate-4-semialdehyde into homoserine is shown below:[5]
- L-Aspartate-4-semialdehyde + NAD(P)H + H+ homoserine + NAD(P)+
Homoserine represents another branch in the aspartate pathway, as it can progress down one of two pathways to eventually become one of two amino acids: threonine or methionine.This aspartate pathway is present in plants and bacteria, allowing them to synthesize lysine, methionine, and threonine. This pathway is not present in humans or other animals, however. The lack of this pathway means that humans need to take in these amino acids through their diet, which is why they are called essential amino acids.[6][7]
File:L-Aspartate-4-Semialdehyde.svg | |
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Other names
(2S)-2-amino-4-oxobutanoic acid
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Identifiers | |
3D model (JSmol)
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ChEBI | |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C4H7NO3 | |
Molar mass | 117.104 g·mol−1 |
Appearance | Solid |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
- ^ Viola, R.E. (2001). "The central enzymes of the amino acid family of biosynthesis". Accounts of Chemical Research. 34 (5): 339–349. doi:10.1021/2far000057q (inactive 2020-12-23).
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: CS1 maint: DOI inactive as of December 2020 (link) - ^ Thangavelu, B.; Bhansali, P.; Viola, R.E. (2015-10-15). "Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors". Bioorganic & Medicinal Chemistry. 23 (20): 6622–6631. doi:10.1016/j.bmc.2015.09.017. PMC 4601562. PMID 26404410.
- ^ Mazelis, M.; Whatley, F.R.; Whatley, J. (December 1977). "The enzymology of lysine biosynthesis in higher plants. The occurrence, characterization and some regulatory properties of dihydrodipicolinate synthase". FEBS Letters. 84 (2): 236–240. doi:10.1016/0014-5793(77)80696-0. PMID 598503. S2CID 11088733.
- ^ Viola, R.E.; Faehnle, C.R.; Blanco, J.; Moore, R.A.; Liu, X.; Arachea, B.T.; Pavlovsky, A.G. (2010-12-22). "The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis". Journal of Amino Acids. 2011: 352–538. doi:10.4061/2011/352538. PMC 3276109. PMID 22332000.
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: CS1 maint: unflagged free DOI (link) - ^ Thomas, D.; Barbey, R.; Surdin-Kerjan, Y. (June 1993). "Evolutionary relationships between yeast and bacterial homoserine dehydrogenases". FEBS Letters. 323 (3): 289–293. doi:10.1016/0014-5793(93)81359-8. PMID 8500624. S2CID 23964791.
- ^ Viola, R.E.; Faehnle, C.R.; Blanco, J.; Moore, R.A.; Liu, X.; Arachea, B.T.; Pavlovsky, A.G. (2010-12-22). "The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis". Journal of Amino Acids. 2011: 352–538. doi:10.4061/2011/352538. PMC 3276109. PMID 22332000.
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: CS1 maint: unflagged free DOI (link) - ^ Berg, Jeremy M.; Tymoczko, John L.; Gatto, Gergory J. Jr.; Stryer, Lubert (2015). Biochemistry. New York, NY: W.H. Freeman and Company. p. 719. ISBN 978-1-4641-2610-9.
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