Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and AMPA: Difference between pages

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| Watchedfields = changed

| verifiedrevid = 477236183

| IUPACName = 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid

|Section1={{Chembox Identifiers

| IUPHAR_ligand = 4131

| InChIKey = UUDAMDVQRQNNHZ-UHFFFAOYAT

| CASNo = 74341-63-2

| PubChem = 1221

| ChEMBL = 276815

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| KEGG_Ref = C13672

| InChI = 1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| MeSHName = AMPA

|Section2={{Chembox Properties

| C=7 | H=10 | N=2 | O=4

| Appearance =

| Density =

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|Section3={{Chembox Hazards

| MainHazards =

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'''α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid''', better known as '''AMPA''', is a [[Chemical compound|compound]] that is a specific [[agonist]] for the [[AMPA receptor]], where it mimics the effects of the [[neurotransmitter]] [[Glutamate (neurotransmitter)|glutamate]].<ref name=Purves2008>{{cite book |author=Purves, Dale |author2=George J. Augustine |author3=David Fitzpatrick |author4=William C. Hall |author5=Anthony-Samuel LaMantia |author6=James O. McNamara |author7=Leonard E. White |name-list-style=amp|title=Neuroscience|edition=4th|publisher=Sinauer Associates|pages=128–33|year=2008|isbn=978-0-87893-697-7}}</ref>

There are several types of glutamatergic ion channels in the central nervous system including AMPA, [[kainic acid]] and [[N-Methyl-D-aspartic acid|''N''-methyl-<small>D</small>-aspartic acid]] (NMDA) channels. In the [[Chemical synapse|synapse]], these receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.<ref name=Dinh2009>{{cite journal|last1=Dinh|first1=L|author2=Nguyen T |author3=Salgado H |author4=Atzori M |title=Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat|journal=Neurochem Res|volume=34|issue=11|pages=1896–906|year=2009|pmid=19357950|doi=10.1007/s11064-009-9966-z|s2cid=25255160}}</ref> AMPA generates [[Fast Excitatory Postsynaptic Potential|fast]] [[excitatory postsynaptic potential]]s (EPSP).<ref name=Purves2008/> AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na⁺ and K⁺ and therefore have an [[equilibrium potential]] near 0&nbsp;mV.

AMPA was first synthesized, along with several other [[ibotenic acid]] derivatives, by Krogsgaard-Larsen, Honoré, and others toward differentiating glutamate sensitive receptors from aspartate sensitive receptors.<ref name = KrogsgaardLarsen1980>{{cite journal |last1=Krogsgaard-Larsen|first1=P|author2=Honore T |author3=Hansen JJ |author4=Curtis DR|author5=Lodge D |title=New class of glutamate agonist structurally related to ibotenic acid|journal=Nature|volume=284|pages=64–66|year=1980|issue=5751|pmid=6101908|doi=10.1038/284064a0|bibcode=1980Natur.284...64K|s2cid=4252428}}</ref>

==See also==

* [[Ampakine]]

==References==

{{Reflist|2}}

{{Ionotropic glutamate receptor modulators}}

[[Category:AMPA receptor agonists]]

[[Category:Kainate receptor agonists]]

[[Category:Alpha-Amino acids]]

[[Category:Isoxazoles]]

[[Category:Glutamate (neurotransmitter)]]